{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T09:04:54Z","timestamp":1772615094087,"version":"3.50.1"},"reference-count":14,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2,5]]},"abstract":"<jats:p>Several risk groups are known for the rare but serious, frequently fatal, viscerotropic reactions following live yellow fever virus vaccine (YEL-AVD). Establishing additional risk groups is hampered by ignorance of the numbers of vaccinees in factor-specific risk groups thus preventing their use as denominators in odds ratios (ORs). Here, we use an equation to calculate ORs using the prevalence of the factor-specific risk group in the population who remain well. The 95% confidence limits and <jats:italic>P<\/jats:italic> values can also be calculated. Moreover, if the estimate of the prevalence is imprecise, discrimination analysis can indicate the prevalence at which the confidence interval results in an OR of \u223c1 revealing if the prevalence might be higher without yielding a non-significant result. These methods confirm some potential risk groups for YEL-AVD and cast doubt on another. They should prove useful in situations in which factor-specific risk group denominator data are not available.<\/jats:p>","DOI":"10.4269\/ajtmh.13-0542","type":"journal-article","created":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T04:05:29Z","timestamp":1389067529000},"page":"267-271","source":"Crossref","is-referenced-by-count":12,"title":["Defining Risk Groups to Yellow Fever Vaccine-Associated Viscerotropic Disease in the Absence of Denominator Data"],"prefix":"10.4269","volume":"90","author":[{"given":"Stephen J.","family":"Seligman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel E.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuval","family":"Itan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Laurent","family":"Casanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Pezzullo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Vaccines","first-page":"870","article-title":"Yellow fever vaccine","author":"Monath","year":"2012"},{"key":"R2","series-title":"Expert Rev Vaccines","first-page":"427","article-title":"Review of the risks and benefits of yellow fever vaccination including some new analyses","volume":"11","author":"Monath","year":"2012"},{"key":"R3","series-title":"Lancet","first-page":"936","article-title":"History of thymoma and yellow fever 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yellow fever vaccine-associated disease","volume":"125","author":"Isenman","year":"2012"},{"key":"R9","series-title":"Vaccine","first-page":"1819","article-title":"Adverse events following yellow fever preventive vaccination campaigns in eight African countries from 2007 to 2010","volume":"31","author":"Breugelmans","year":"2013"},{"key":"R10","series-title":"BMJ","first-page":"d2304","article-title":"How to obtain the P value from a confidence interval","volume":"343","author":"Altman","year":"2011"},{"key":"R11","series-title":"J Exp Med","first-page":"1839","article-title":"Revisiting Crohn's disease as a primary immunodeficiency of macrophages","volume":"206","author":"Casanova","year":"2009"},{"key":"R12","series-title":"J Infect Dis","first-page":"500","article-title":"Case of yellow fever vaccine-associated viscerotropic disease with prolonged viremia, robust adaptive immune responses, and polymorphisms in CCR5 and RANTES 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Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/90\/2\/article-p267.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/90\/2\/article-p267.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/90\/2\/article-p267.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T21:34:03Z","timestamp":1723066443000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/90\/2\/article-p267.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,5]]},"references-count":14,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.13-0542","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,5]]}}}