{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T04:33:44Z","timestamp":1768278824667,"version":"3.49.0"},"reference-count":34,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,10,1]]},"abstract":"<jats:p>Because of emerging resistance to existing drugs, new chemical classes of antimalarial drugs are urgently needed. We have rationally designed a library of compounds that were predicted to accumulate in the digestive vacuole and then decrystallize hemozoin by breaking the iron carboxylate bond in hemozoin. We report the synthesis of 16 naphthothiazolium salts with amine-bearing side chains and their activities against the erythrocytic stage of <jats:italic>Plasmodium falciparum in vitro<\/jats:italic>. KSWI-855, the compound with the highest efficacy against the asexual stages of <jats:italic>P. falciparum in vitro<\/jats:italic>, also had <jats:italic>in vitro<\/jats:italic> activity against <jats:italic>P. falciparum<\/jats:italic> gametocytes and <jats:italic>in vivo<\/jats:italic> activity against <jats:italic>P. berghei<\/jats:italic> in a murine malaria model.<\/jats:p>","DOI":"10.4269\/ajtmh.13-0565","type":"journal-article","created":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T05:22:06Z","timestamp":1409721726000},"page":"824-832","source":"Crossref","is-referenced-by-count":3,"title":["In vitro and In vivo Antimalarial Activity of Amphiphilic Naphthothiazolium Salts with Amine-Bearing Side Chains"],"prefix":"10.4269","volume":"91","author":[{"given":"Peter","family":"Ulrich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory 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