{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:42:09Z","timestamp":1792651329022,"version":"4.5.0"},"reference-count":45,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11,5]]},"abstract":"<jats:p><jats:italic>Schistosoma mansoni<\/jats:italic> disease is endemic in most parts of rural Zambia, and associated complications are common. We conducted a cross-sectional study among 754 people in rural communities of Kaoma District, western Zambia to determine the burden of <jats:italic>S. mansoni<\/jats:italic> infection and associated morbidity. Parasitology and ultrasonography assessments were conducted on consenting participants. The overall prevalence of <jats:italic>S. mansoni<\/jats:italic> infection and geometric mean egg count (GMEC) were 42.4% (304) and 86.6 eggs per gram (95% confidence interval = 75.6\u201399.6), respectively. Prevalence was highest in the age group of 15\u201319 years old (adjusted prevalence ratio = 1.70, <jats:italic>P<\/jats:italic> = 0.017). <jats:italic>S. mansoni<\/jats:italic>-related portal fibrosis was detected in 26% of the participants screened. Participants above 39 years old were 2.93 times more likely to have fibrosis than the 7\u20139 years old age group (<jats:italic>P<\/jats:italic> = 0.004). The study highlights the high burden of <jats:italic>S. mansoni<\/jats:italic> disease in this area and calls for immediate interventions to avert complications associated with the disease.<\/jats:p>","DOI":"10.4269\/ajtmh.13-0612","type":"journal-article","created":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T07:20:42Z","timestamp":1411456842000},"page":"965-972","source":"Crossref","is-referenced-by-count":23,"title":["High Schistosoma mansoni Disease Burden in a Rural District of Western Zambia"],"prefix":"10.4269","volume":"91","author":[{"given":"Mable M.","family":"Mutengo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C. 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A Practical Guide to the Standardized Use of Ultrasonography for the Assessment of Schistosomiasis Related Morbidity","author":"Richter","year":"2000"},{"key":"R16","series-title":"Trop Med Int Health","first-page":"1286","article-title":"Large scale evaluation of WHO's ultrasonographic staging system of schistosomal periportal fibrosis in Ethiopia","volume":"11","author":"Berhe","year":"2006"},{"key":"R17","series-title":"Trop Med Int Health","first-page":"461","article-title":"Detailed clinical and ultrasound examination of children and adolescents in a Schistosoma mansoni endemic area in Kenya: hepatosplenic disease in the absence of portal fibrosis","volume":"9","author":"Vennervald","year":"2004"},{"key":"R18","series-title":"Parasitol Today","first-page":"274","article-title":"Underestimation of Schistosoma mansoni prevalences","volume":"8","author":"de Vlas","year":"1992"},{"key":"R19","series-title":"Am J Trop Med Hyg","first-page":"319","article-title":"Day-to-day egg count fluctuation in Schistosoma mansoni infection and its operational implications","volume":"54","author":"Engels","year":"1996"},{"key":"R20","series-title":"Am J Trop Med Hyg","first-page":"1079","article-title":"Intensity of Schistosoma mansoni, hepatitis B, age, and sex predict levels of hepatic periportal thickening\/fibrosis (PPT\/F): a large-scale community-based study in Ethiopia","volume":"77","author":"Berhe","year":"2007"},{"key":"R21","series-title":"J Infect Dis","first-page":"960","article-title":"Prevalence and familial aggregation of schistosomal liver morbidity in Kenya: evaluation by new ultrasound criteria","volume":"183","author":"Kariuki","year":"2001"},{"key":"R22","series-title":"Trans R Soc Trop Med Hyg","first-page":"711","article-title":"Epidemiology and morbidity of Schistosoma mansoni infection in a fishing community along Lake Albert in Uganda","volume":"98","author":"Kabatereine","year":"2004"},{"key":"R23","series-title":"PLoS Negl Trop 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