{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:32:20Z","timestamp":1762176740292},"reference-count":15,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,8,6]]},"abstract":"<jats:p>Haiti is one of two remaining malaria-endemic countries in the Caribbean. To decrease malaria transmission in Haiti, primaquine was recently added to the malaria treatment public health policy. One limitation of primaquine is that, at certain doses, primaquine can cause hemolytic anemia in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDd). In this study, we genotyped two mutations (A376G and G202A), which confer the most common G6PDd variant in West African populations, G6PDd A\u2212. We estimated the frequency of G6PDd A\u2212 in a sample of febrile patients enrolled in an on-going malaria study who represent a potential target population for a primaquine mass drug administration. We found that 33 of 168 individuals carried the G6PDd A\u2212 allele (includes A\u2212 hemizygous males, A\u2212 homozygous or heterozygous females) and could experience toxicity if treated with primaquine. These data inform discussions on safe and effective primaquine dosing and future malaria elimination strategies for Haiti.<\/jats:p>","DOI":"10.4269\/ajtmh.14-0053","type":"journal-article","created":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T07:04:23Z","timestamp":1401779063000},"page":"412-414","source":"Crossref","is-referenced-by-count":4,"title":["Glucose-6-Phosphate Dehydrogenase Deficiency A\u2212 Variant in Febrile Patients in Haiti"],"prefix":"10.4269","volume":"91","author":[{"given":"Tamar E.","family":"Carter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halley","family":"Maloy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"von Fricken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"St. Victor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean R.","family":"Romain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard A.","family":"Okech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Connie J.","family":"Mulligan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Blood","first-page":"2550","article-title":"Molecular heterogeneity of glucose-6-phosphate dehydrogenase A","volume":"74","author":"Beutler","year":"1989"},{"key":"R2","series-title":"J Mol Med (Berl)","first-page":"581","article-title":"Glucose-6-phosphate dehydrogenase deficiency and malaria","volume":"76","author":"Ruwende","year":"1998"},{"key":"R3","series-title":"Malar J","first-page":"418","article-title":"Rationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is common","volume":"11","author":"White","year":"2012"},{"key":"R4","series-title":"Adv Parasitol","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/B978-0-12-407826-0.00004-7","article-title":"G6PD deficiency: global distribution, genetic variants and primaquine therapy","volume":"81","author":"Howes","year":"2013"},{"year":"2012","series-title":"The Safety and Effectiveness of Single Dose Primaquine as a P. 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