{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:45:37Z","timestamp":1790070337529,"version":"4.0.1"},"reference-count":15,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,3]]},"abstract":"<jats:p>Malarial retinopathy allows detailed study of central nervous system vascular pathology in living patients with severe malaria. An adult with cerebral malaria is described who had prominent retinal whitening with corresponding retinal microvascular obstruction, vessel dilatation, increased vascular tortuosity, and blood retinal barrier leakage with decreased visual acuity, all of which resolved on recovery. Additional study of these features and their potential role in elucidating the pathogenesis of cerebral malaria is warranted.<\/jats:p>","DOI":"10.4269\/ajtmh.14-0116","type":"journal-article","created":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T04:06:43Z","timestamp":1402978003000},"page":"493-495","source":"Crossref","is-referenced-by-count":4,"title":["Reversibility of Retinal Microvascular Changes in Severe Falciparum Malaria"],"prefix":"10.4269","volume":"91","author":[{"given":"Richard J.","family":"Maude","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh W. F.","family":"Kingston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjib","family":"Mohanty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saroj K.","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjen M.","family":"Dondorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Br J Ophthalmol","first-page":"274","article-title":"Retinal vessel dilatation and elongation precedes diabetic macular oedema","volume":"81","author":"Kristinsson","year":"1997"},{"key":"R2","series-title":"Ophthalmology","first-page":"606","article-title":"Patchy ischemic retinal whitening","volume":"111","author":"Browning","year":"2004"},{"key":"R3","series-title":"Trans R Soc Trop Med Hyg","first-page":"661","article-title":"The eye in cerebral malaria: what can it teach us?","volume":"103","author":"Maude","year":"2009"},{"key":"R4","series-title":"Eur J Ophthalmol","first-page":"653","article-title":"Topography of patchy retinal whitening during acute perfused retinal vein occlusion by optical coherence tomography and adaptive optics fundus imaging","volume":"21","author":"Sarda","year":"2011"},{"key":"R5","series-title":"Trans R Soc Trop Med Hyg","first-page":"665","article-title":"The spectrum of retinopathy in adults with Plasmodium falciparum malaria","volume":"103","author":"Maude","year":"2009"},{"key":"R6","series-title":"Trans R Soc Trop Med Hyg","first-page":"1089","article-title":"Using malarial retinopathy to improve the classification of children with cerebral malaria","volume":"102","author":"Lewallen","year":"2008"},{"key":"R7","series-title":"Lancet","first-page":"1261","article-title":"Prognostic value of CSF lactate in cerebral malaria","volume":"1","author":"White","year":"1987"},{"key":"R8","series-title":"Malar J","first-page":"232","article-title":"Retinopathy in severe malaria in Ghanaian children\u2013overlap between fundus changes in cerebral and non-cerebral malaria","volume":"9","author":"Essuman","year":"2010"},{"key":"R9","series-title":"Arch Ophthalmol","first-page":"1141","article-title":"Prognostic significance and course of retinopathy in children with severe malaria","volume":"122","author":"Beare","year":"2004"},{"key":"R10","series-title":"J Infect Dis","first-page":"263","article-title":"Perfusion abnormalities in children with cerebral malaria and malarial retinopathy","volume":"199","author":"Beare","year":"2009"},{"key":"R11","series-title":"Arch Ophthalmol","first-page":"924","article-title":"Clinical-histopathological correlation of the abnormal retinal vessels in cerebral malaria","volume":"118","author":"Lewallen","year":"2000"},{"key":"R12","series-title":"Am J Pathol","first-page":"395","article-title":"A quantitative analysis of the microvascular sequestration of malaria parasites in the human brain","volume":"155","author":"Silamut","year":"1999"},{"key":"R13","series-title":"J Infect Dis","first-page":"663","article-title":"Sequestration and microvascular congestion are associated with coma in human cerebral malaria","volume":"205","author":"Ponsford","year":"2012"},{"key":"R14","series-title":"J Infect Dis","first-page":"208","article-title":"The distribution and intensity of parasite sequestration in comatose Malawian children","volume":"194","author":"Seydel","year":"2006"},{"key":"R15","series-title":"Int J Med Inform","first-page":"239","article-title":"Measurement and classification of retinal vascular tortuosity","volume":"53","author":"Hart","year":"1999"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/91\/3\/article-p493.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/91\/3\/article-p493.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/91\/3\/article-p493.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T21:16:38Z","timestamp":1723065398000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/91\/3\/article-p493.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,3]]},"references-count":15,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.14-0116","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,3]]}}}