{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:34:29Z","timestamp":1784043269089,"version":"3.55.0"},"reference-count":68,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,5,6]]},"abstract":"<jats:p>We have previously shown that anti\u2013dengue virus nonstructural protein 1 (anti-DENV NS1) antibodies cross-react with endothelial cells, and several autoantigens have been identified. This study shows that the antibody levels against these self-proteins are higher in sera from patients with dengue hemorrhagic fever (DHF) than those in control sera. Anti\u2013protein disulfide isomerase (PDI) and anti\u2013heat shock protein 60 (anti-HSP60) IgM levels correlated with both anti\u2013endothelial cells and anti-DENV NS1 IgM titers. A cross-reactive epitope on the NS1 amino acid residues 311\u2013330 (P311\u2013330) had been predicted. We further found that there were higher IgM and IgG levels against P311\u2013330 in DHF patients' sera than those in the control sera. In addition, correlations were observed between anti-PDI with anti-P311\u2013330 IgM and IgG levels, respectively. Therefore, our results indicate that DENV NS1 P311\u2013330 is a major epitope for cross-reactive antibodies to PDI on the endothelial cell surface, which may play an important role in DENV infection\u2013induced autoimmunity.<\/jats:p>","DOI":"10.4269\/ajtmh.14-0162","type":"journal-article","created":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T02:53:20Z","timestamp":1426042400000},"page":"989-995","source":"Crossref","is-referenced-by-count":20,"title":["Correlation Between Serum Levels of Anti-Endothelial Cell Autoantigen and Anti-Dengue Virus Nonstructural Protein 1 Antibodies in Dengue 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