{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:44:51Z","timestamp":1784357091931,"version":"3.55.0"},"reference-count":22,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11,5]]},"abstract":"<jats:p>Visceral leishmaniasis (VL) is a re-emerging zoonosis of worldwide distribution. Monocyte chemotactic protein-1 (MCP-1) and malondialdehyde (MDA) are inflammation biomarkers that have never been investigated in VL. The aim of this study is to investigate the association between renal abnormalities and inflammation biomarkers in VL. This study is a preliminary prospective study with 16 VL adult patients evaluated before treatment compared with a group of 13 healthy volunteers and 5 VL patients evaluated after treatment. Urinary concentration and acidification tests were performed. MCP-1 and MDA were quantified in urine. Urinary concentration deficit was found in all VL patients before (100%) and four VL patients after (80%) treatment. Urinary acidification deficit was found in nine cases before (56.2%) and two cases after (40%) treatment. Urinary MCP-1 (374 \u00b1 359 versus 42 \u00b1 29 pg\/mg creatinine, <jats:italic>P<\/jats:italic> = 0.002) as well as urinary MDA (5.4 \u00b1 2.6 versus 2.0 \u00b1 0.8 \u03bcmol\/mL) showed significant differences between VL patients and controls. These data show that VL patients present urinary concentration and acidification deficit, which can persist even after specific treatment. Urinary MCP-1 and MDA are elevated in patients with VL, which suggests renal inflammation and incipient renal damage.<\/jats:p>","DOI":"10.4269\/ajtmh.14-0167","type":"journal-article","created":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T04:02:08Z","timestamp":1407816128000},"page":"908-911","source":"Crossref","is-referenced-by-count":21,"title":["Preliminary Study on Tubuloglomerular Dysfunction and Evidence of Renal Inflammation in Patients with Visceral Leishmaniasis"],"prefix":"10.4269","volume":"91","author":[{"given":"Michelle J. C.","family":"Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldo B.","family":"Silva Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline M.","family":"Sampaio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara L.","family":"Montenegro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia P.","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme A. L.","family":"Henn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermano A. L.","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gdayllon C.","family":"Meneses","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice M. C.","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth F.","family":"Daher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Rev Bras Epidemiol","first-page":"338","article-title":"Visceral leishmaniasis in Brazil: current status, challenges and prospects","volume":"7","author":"Gontijo","year":"2004"},{"key":"R2","series-title":"Manual de vigil\u00e2ncia e controle da leishmaniose visceral (S\u00e9rie A. Normas e Manuais T\u00e9cnicos)","author":"Minist\u00e9rio da Sa\u00fade, Secretaria de Vigil\u00e2ncia em Sa\u00fade. Departamento de Vigil\u00e2ncia Epidemiol\u00f3gica, Brasil","year":"2006"},{"key":"R3","series-title":"NDT Plus","first-page":"147","article-title":"Renal involvement in leishmaniasis: a review of the literature","volume":"4","author":"Clementi","year":"2011"},{"key":"R4","series-title":"Am J Kidney Dis","first-page":"501","article-title":"Parasitic kidney disease: milestones in the evolution of our knowledge","volume":"61","author":"Barsoum","year":"2013"},{"key":"R5","series-title":"J Bras Neurol","first-page":"172","article-title":"Acid-base disturbances in visceral leishmaniasis","volume":"30","author":"Lima Verde","year":"2008"},{"key":"R6","series-title":"Clin Nephrol","first-page":"492","article-title":"Renal tubular dysfunction in human visceral leishmaniasis (kala-azar)","volume":"71","author":"Lima Verde","year":"2009"},{"key":"R7","series-title":"Rev Soc Trop Med Hyg","first-page":"531","article-title":"Interstitial nephritis in human kala-azar","volume":"77","author":"Duarte","year":"1983"},{"key":"R8","series-title":"Am J Kidney Dis","first-page":"22","article-title":"Renal involvement in visceral leishmaniasis","volume":"7","author":"Dutra","year":"1985"},{"key":"R9","series-title":"Rev Soc Bras Med Trop","first-page":"386","article-title":"Is severe visceral leishmaniasis a systemic inflammatory response syndrome? 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