{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:04:04Z","timestamp":1791849844816,"version":"4.3.4"},"reference-count":64,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,12,3]]},"abstract":"<jats:p>Splenic infarction is a rare complication of malaria. We report two recent cases of splenic infarction after <jats:italic>Plasmodium vivax<\/jats:italic> infection. No systematic review of malaria-induced splenic infarction was available, therefore we conducted a systematic review of the English, French, and Spanish literature in PubMed and KoreaMed for reports of malaria-associated splenic infarction from 1960 to 2012. Of the 40 cases collected on splenic infarction by <jats:italic>Plasmodium<\/jats:italic> species, 23 involved <jats:italic>P. vivax<\/jats:italic>, 11 <jats:italic>Plasmodium falciparum<\/jats:italic>, one <jats:italic>Plasmodium ovale<\/jats:italic>, and five a mixed infection of <jats:italic>P. vivax<\/jats:italic> and <jats:italic>P. falciparum<\/jats:italic>. Of the 40 cases, 2 (5.0%) involved splenectomy and 5 (12.5%) were accompanied by splenic rupture. The median time from symptom onset to diagnosis was 8.5 days (range, 3\u201390 days). Improved findings after treatment were observed in 8 (88.9%) of 9 patients with splenic infarction on follow-up by computed tomography or ultrasonography. All patients survived after treatment with the exception of one patient with cerebral malaria. Clinicians should consider the possibility of splenic infarction when malaria-infected patients have left upper quadrant pain.<\/jats:p>","DOI":"10.4269\/ajtmh.14-0190","type":"journal-article","created":{"date-parts":[[2014,10,8]],"date-time":"2014-10-08T00:14:20Z","timestamp":1412727260000},"page":"1094-1100","source":"Crossref","is-referenced-by-count":23,"title":["Malaria-Induced Splenic Infarction"],"prefix":"10.4269","volume":"91","author":[{"given":"Jeong-Hwan","family":"Hwang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Seop","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Emerg Med Clin North Am","first-page":"113","article-title":"Malaria","volume":"15","author":"Stanley","year":"1997"},{"key":"R2","series-title":"World Malaria Report","author":"World Health 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