{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:23:59Z","timestamp":1789590239982,"version":"build-2803163510"},"reference-count":105,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,3]]},"abstract":"<jats:p>Rickettsial infections represent a major cause of non-malarial febrile illnesses among the residents of Southeast Asia and returned travelers from that region. There are several challenges in recognition, diagnosis, and management of rickettsioses endemic to Southeast Asia. This review focuses on the prevalent rickettsial infections, namely, murine typhus (<jats:italic>Rickettsia typhi<\/jats:italic>), scrub typhus (<jats:italic>Orientia tsutsugamushi<\/jats:italic>), and members of spotted fever group rickettsiae. Information on epidemiology and regional variance in the prevalence of rickettsial infections is analyzed. Clinical characteristics of main groups of rickettsioses, unusual presentations, and common pitfalls in diagnosis are further discussed. In particular, relevant epidemiologic and clinical aspects on emerging spotted fever group rickettsiae in the region, such as <jats:italic>Rickettsia honei<\/jats:italic>, <jats:italic>R. felis<\/jats:italic>, <jats:italic>R. japonica<\/jats:italic>, and <jats:italic>R. helvetica<\/jats:italic>, are presented. Furthermore, challenges in laboratory diagnosis and management aspects of rickettsial infections unique to Southeast Asia are discussed, and data on emerging resistance to antimicrobial drugs and treatment\/prevention options are also reviewed.<\/jats:p>","DOI":"10.4269\/ajtmh.14-0191","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T06:03:11Z","timestamp":1403589791000},"page":"451-460","source":"Crossref","is-referenced-by-count":96,"title":["Rickettsial Infections in Southeast Asia: Implications for Local Populace and Febrile Returned Travelers"],"prefix":"10.4269","volume":"91","author":[{"given":"Ar Kar","family":"Aung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis W.","family":"Spelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronan J.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Graves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"PLoS ONE","first-page":"e44269","article-title":"Mapping the aetiology of non-malarial febrile illness in Southeast Asia through a systematic review: terra incognita impairing treatment policies","volume":"7","author":"Acestor","year":"2012"},{"key":"R2","series-title":"Postgrad Med J","first-page":"269","article-title":"Rickettsial diseases: the typhus group of fevers: a review","volume":"76","author":"Cowan","year":"2000"},{"key":"R3","series-title":"Emerg Infect Dis","first-page":"592","article-title":"Emerging rickettsioses of the Thai-Myanmar border","volume":"9","author":"Parola","year":"2003"},{"key":"R4","series-title":"PLoS Negl Trop 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