{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T20:45:00Z","timestamp":1783543500207,"version":"3.55.0"},"reference-count":26,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,10,1]]},"abstract":"<jats:p>A barrier to eliminating <jats:italic>Plasmodium vivax<\/jats:italic> malaria is inadequate treatment of infected patients. 8-Aminoquinoline\u2013based drugs clear the parasite; however, people with glucose-6-phosphate dehydrogenase (G6PD) deficiency are at risk for hemolysis from these drugs. Understanding the performance of G6PD deficiency tests is critical for patient safety. Two quantitative assays and two qualitative tests were evaluated. The comparison of quantitative assays gave a Pearson correlation coefficient of 0.7585 with significant difference in mean G6PD activity, highlighting the need to adhere to a single reference assay. Both qualitative tests had high sensitivity and negative predictive value at a cutoff G6PD value of 40% of normal activity if interpreted conservatively and performed under laboratory conditions. The performance of both tests dropped at a cutoff level of 45%. Cytochemical staining of specimens confirmed that heterozygous females with &gt; 50% G6PD-deficient cells can seem normal by phenotypic tests.<\/jats:p>","DOI":"10.4269\/ajtmh.14-0194","type":"journal-article","created":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T03:10:40Z","timestamp":1406603440000},"page":"854-861","source":"Crossref","is-referenced-by-count":80,"title":["Comparison of Quantitative and Qualitative Tests for Glucose-6-Phosphate Dehydrogenase Deficiency"],"prefix":"10.4269","volume":"91","author":[{"given":"Nicole","family":"LaRue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon T.","family":"Leader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Bansil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"McGray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kalnoky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqiang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo J.","family":"Domingo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Blood","first-page":"3613","article-title":"G6PD deficiency","volume":"84","author":"Beutler","year":"1994"},{"key":"R2","series-title":"Malar J","first-page":"391","article-title":"G6PD testing in support of treatment and elimination of malaria: recommendations for evaluation of G6PD tests","volume":"12","author":"Domingo","year":"2013"},{"key":"R3","series-title":"Malar J","first-page":"112","article-title":"Review of key knowledge gaps in glucose-6-phosphate dehydrogenase deficiency detection with regard to the safe clinical deployment of 8-aminoquinoline treatment regimens: a workshop report","volume":"12","author":"von Seidlein","year":"2013"},{"key":"R4","series-title":"PLoS Med","first-page":"e1001339","article-title":"G6PD deficiency prevalence and estimates of affected populations in malaria endemic countries: a geostatistical model-based map","volume":"9","author":"Howes","year":"2012"},{"key":"R5","series-title":"Adv Parasitol","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/B978-0-12-407826-0.00004-7","article-title":"G6PD deficiency: global distribution, genetic variants and primaquine therapy","volume":"81","author":"Howes","year":"2013"},{"key":"R6","series-title":"Blood Cells Mol Dis","first-page":"267","article-title":"The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis","volume":"42","author":"Nkhoma","year":"2009"},{"key":"R7","series-title":"Lancet","first-page":"64","article-title":"Glucose-6-phosphate dehydrogenase deficiency","volume":"371","author":"Cappellini","year":"2008"},{"key":"R8","series-title":"The Metabolic and Molecular Basis of Inherited Disease","first-page":"4517","article-title":"Glucose-6-phosphate dehydrogenase deficiency","author":"Luzzatto","year":"2001"},{"key":"R9","series-title":"Blood Cells Mol Dis","first-page":"154","article-title":"Glucose-6-phosphate dehydrogenase (G6PD) mutations database: review of the \u201cold\u201d and update of the new mutations","volume":"48","author":"Minucci","year":"2012"},{"key":"R10","series-title":"Bull World Health Organ","first-page":"601","article-title":"Glucose-6-phosphate dehydrogenase deficiency: WHO Working Group","volume":"67","author":"World Health Organization","year":"1989"},{"key":"R11","series-title":"Standardization of Procedures for the Study of Glucose-6-Phosphate Dehydrogenase: Report of a WHO Scientific Group. 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