{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:23:07Z","timestamp":1792002187631,"version":"4.4.0"},"reference-count":24,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3,4]]},"abstract":"<jats:p>Leptospirosis is a common disease in tropical countries, and the kidney is one of the main target organs. Membrane proteins of <jats:italic>Leptospira<\/jats:italic> are capable of causing endothelial damage <jats:italic>in vitro<\/jats:italic>, but there have been no studies in humans evaluating endothelial glycocalyx damage and its correlation with acute kidney injury (AKI). We performed a cohort study in an outbreak of leptospirosis among military personnel. AKI was diagnosed in 14 of 46 (30.4%) patients. Leptospirosis was associated with higher levels of intercellular adhesion molecule-1 (ICAM-1; 483.1 \u00b1 31.7 versus 234.9 \u00b1 24.4 mg\/L, <jats:italic>P<\/jats:italic> &lt; 0.001) and syndecan-1 (73.7 \u00b1 15.9 versus 21.2 \u00b1 7.9 ng\/mL, <jats:italic>P<\/jats:italic> &lt; 0.001) compared with exposed controls. Patients with leptospirosis-associated AKI had increased level of syndecan-1 (112.1 \u00b1 45.4 versus 41.5 \u00b1 11.7 ng\/mL, <jats:italic>P<\/jats:italic> = 0.021) and ICAM-1 (576.9 \u00b1 70.4 versus 434.9 \u00b1 35.3, <jats:italic>P<\/jats:italic> = 0.034) compared with leptospirosis patients with no AKI. Association was verified between syndecan-1 and ICAM-1 with serum creatinine elevation and neutrophil gelatinase-associated lipocalin (NGAL) levels. This association remained even after multivariate analysis including other AKI-associated characteristics. Endothelial injury biomarkers are associated with leptospirosis-associated renal damage.<\/jats:p>","DOI":"10.4269\/ajtmh.14-0232","type":"journal-article","created":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T02:16:18Z","timestamp":1422324978000},"page":"611-616","source":"Crossref","is-referenced-by-count":55,"title":["Endothelial Glycocalyx Damage is Associated with Leptospirosis Acute Kidney Injury"],"prefix":"10.4269","volume":"92","author":[{"given":"Alexandre Braga","family":"Lib\u00f3rio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Boecker Munoz","family":"Braz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Carlos","family":"Seguro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gdayllon C.","family":"Meneses","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Macedo de Oliveira","family":"Neves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle Carvalho","family":"Pedrosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano Pamplona de G\u00f3es","family":"Cavalcanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice Maria Costa","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth de Francesco","family":"Daher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Infect Genet Evol","first-page":"760","article-title":"A century of Leptospira strain typing","volume":"9","author":"Cerqueira","year":"2009"},{"key":"R2","series-title":"Int J Infect Dis","first-page":"351","article-title":"The globalization of leptospirosis: worldwide incidence trends","volume":"12","author":"Pappas","year":"2008"},{"key":"R3","series-title":"Nat Rev Microbiol","first-page":"736","article-title":"Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen","volume":"7","author":"Ko","year":"2009"},{"key":"R4","series-title":"Semin Nephrol","first-page":"383","article-title":"Leptospiral nephropathy","volume":"28","author":"Andrade","year":"2008"},{"key":"R5","series-title":"Am J Trop Med Hyg","first-page":"479","article-title":"Different patterns in a cohort of patients with severe leptospirosis (Weil syndrome): effects of an educational program in an endemic area","volume":"85","author":"Daher","year":"2011"},{"key":"R6","series-title":"Nephron Clin Pract","first-page":"c25","article-title":"Predictors of oliguric acute kidney injury in leptospirosis. 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outer membrane proteins of Leptospira interrogans stimulate human umbilical vein endothelial cells (HUVECS) and express during infection","volume":"45","author":"G\u00f3mez","year":"2008"},{"key":"R12","series-title":"FEMS Microbiol Lett","first-page":"172","article-title":"A novel leptospiral protein increases ICAM-1 and E-selectin expression in human umbilical vein endothelial cells","volume":"276","author":"Vieira","year":"2007"},{"key":"R13","series-title":"PLoS ONE","first-page":"e71743","article-title":"Human hemorrhagic pulmonary leptospirosis: pathological findings and pathophysiological correlations","volume":"8","author":"De Brito","year":"2013"},{"key":"R14","series-title":"J Pathol","first-page":"177","article-title":"Vascular damage in acute experimental leptospirosis of the guinea-pig","volume":"128","author":"De Brito","year":"1979"},{"key":"R15","series-title":"Cardiovasc Res","first-page":"300","article-title":"Therapeutic strategies targeting the endothelial glycocalyx: acute deficits, but great potential","volume":"87","author":"Becker","year":"2010"},{"key":"R16","series-title":"Histol Histopathol","first-page":"177","article-title":"CD138 (syndecan-1) expression in health and disease","volume":"29","author":"Palaiologou","year":"2014"},{"key":"R17","series-title":"PLoS Negl Trop Dis","first-page":"e2457","article-title":"Cytokine response signatures in disease progression and development of severe clinical outcomes for leptospirosis","volume":"7","author":"Reis","year":"2013"},{"key":"R18","series-title":"PLoS Negl Trop Dis","first-page":"e1991","article-title":"Risk factors and predictors of severe leptospirosis in New Caledonia","volume":"7","author":"Tubiana","year":"2013"},{"key":"R19","series-title":"Nephrology (Carlton)","first-page":"269","article-title":"RIFLE and Acute Kidney Injury Network classifications predict mortality in leptospirosis-associated acute kidney injury","volume":"16","author":"Silva 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