{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:30:25Z","timestamp":1790512225603,"version":"4.1.0"},"reference-count":15,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,9,2]]},"abstract":"<jats:p>Hyperreactive Malarial Splenomegaly Syndrome (HMSS) was described and defined before sensitive tests for malaria were available. We present a series of seven individuals who were referred to our clinics with possible HMSS. Chronic malaria was demonstrated in those successfully treated but not in those who failed to respond to therapy. This observation suggests that the newer molecular malaria assays have a role to play in the identification of individuals who are likely to respond to treatment for HMSS in non-endemic regions.<\/jats:p>","DOI":"10.4269\/ajtmh.14-0234","type":"journal-article","created":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T02:35:16Z","timestamp":1437446116000},"page":"573-576","source":"Crossref","is-referenced-by-count":12,"title":["Hyperreactive Malarial Splenomegaly Syndrome\u2014Can the Diagnostic Criteria Be Improved?"],"prefix":"10.4269","volume":"93","author":[{"given":"Alastair","family":"McGregor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Doherty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Lowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Chiodini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Newsholme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Clin Haematol","first-page":"963","article-title":"Tropical splenomegaly. Part 1: tropical Africa","volume":"10","author":"Fakunle","year":"1981"},{"key":"ref2","series-title":"J Clin Invest","first-page":"1821","article-title":"Antibody-mediated killing of suppressor T lymphocytes as a possible cause of macroglobulinemia in the tropical splenomegaly syndrome","volume":"75","author":"Piessens","year":"1985"},{"key":"ref3","series-title":"N Engl J Med","first-page":"337","article-title":"Reduction of suppressor T lymphocytes in the tropical splenomegaly syndrome","volume":"310","author":"Hoffman","year":"1984"},{"key":"ref4","series-title":"Manson's Tropical Diseases","article-title":"Haematological diseases in the tropics","author":"Fleming","year":"2009"},{"key":"ref5","series-title":"Lancet","first-page":"1178","article-title":"Review of diagnostic criteria of hyper-reactive malarial splenomegaly","volume":"349","author":"Bates","year":"1997"},{"key":"ref6","series-title":"BMJ","first-page":"79","article-title":"Tropical splenomegaly syndrome in a Rwandan kindred in Uganda","volume":"3","author":"Ziegler","year":"1972"},{"key":"ref7","series-title":"J Infect Dis","first-page":"157","article-title":"The hyperreactive malarial splenomegaly syndrome in a European: has the treatment a modulatory effect on the immune system?","volume":"161","author":"Betticher","year":"1990"},{"key":"ref8","series-title":"Clin Infect Dis","first-page":"e97","article-title":"Acute Plasmodium falciparum malaria following splenectomy for suspected lymphoma in 2 patients","volume":"40","author":"Bidegain","year":"2005"},{"key":"ref9","series-title":"Mol Biochem Parasitol","first-page":"283","article-title":"Identification of the four human malaria parasite species in field samples by the polymerase chain reaction and detection of a high prevalence of mixed infections","volume":"58","author":"Snounou"},{"key":"ref10","series-title":"Trop Med Int Health","first-page":"146","article-title":"Evidence basis for antimalarial policy change in Sierra Leone: five in vivo efficacy studies of chloroquine, sulphadoxine\u2013pyrimethamine and amodiaquine","volume":"10","author":"Checchi","year":"2005"},{"key":"ref11","series-title":"Diagn Microbiol Infect Dis","first-page":"207","article-title":"Validation of PCR for detection and characterization of parasitaemia in massive splenomegaly attributed clinically to malaria infection","volume":"70","author":"A-Elgayoum","year":"2011"},{"key":"ref12","series-title":"Rev Soc Bras Med Trop","first-page":"257","article-title":"Reduction of spleen size in a child with hyperreactive malarious splenomegaly (HMS) treated outside the Brazilian endemic area of malaria with only one course of quinine","volume":"25","author":"Muniz-Junqueira","year":"1992"},{"key":"ref13","series-title":"Med Mal Infect","first-page":"29","article-title":"Hyperreactive malarial splenomegaly: three clinical cases and literature review","volume":"39","author":"Camara","year":"2009"},{"key":"ref14","series-title":"BMJ","first-page":"429","article-title":"Tropical splenomegaly syndrome in Zambia: further observations and effects of cycloguanil and proguanil","volume":"1","author":"Lowenthal","year":"1971"},{"key":"ref15","series-title":"BMJ","first-page":"378","article-title":"Tropical splenomegaly syndrome: long-term proguanil therapy correlated with spleen size, serum IgM, and lymphocyte transformation","volume":"3","author":"Sagoe","year":"1970"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/93\/3\/article-p573.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/93\/3\/article-p573.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/93\/3\/article-p573.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T19:05:25Z","timestamp":1723057525000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/93\/3\/article-p573.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,2]]},"references-count":15,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.14-0234","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,2]]}}}