{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T21:08:25Z","timestamp":1775423305910,"version":"3.50.1"},"reference-count":28,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,2,4]]},"abstract":"<jats:p>\n                    Scrub typhus usually presents as acute undifferentiated fever. This cross-sectional study included adult patients presenting with acute undifferentiated fever defined as any febrile illness for \u2264 14 days without evidence of localized infection. Scrub typhus cases were defined by an antibody titer of a \u2265 fourfold increase in paired sera, a \u2265 1:160 in a single serum using indirect immunofluorescence assay, or a positive result of the immunochromatographic test. Multiple regression analysis identified predictors associated with scrub typhus to develop a prediction rule. Of 250 cases with known etiology of acute undifferentiated fever, influenza (28.0%), hepatitis A (25.2%), and scrub typhus (16.4%) were major causes. A prediction rule for identifying suspected cases of scrub typhus consisted of age \u2265 65 years (two points), recent fieldwork\/outdoor activities (one point), onset of illness during an outbreak period (two points), myalgia (one point), and eschar (two points). The\n                    <jats:italic>c<\/jats:italic>\n                    statistic was 0.977 (95% confidence interval = 0.960\u20130.994). At a cutoff value \u2265 4, the sensitivity and specificity were 92.7% (79.0\u201398.1%) and 90.9% (86.0\u201394.3%), respectively. Scrub typhus, the third leading cause of acute undifferentiated fever in our region, can be identified early using the prediction rule.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.14-0377","type":"journal-article","created":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:01:27Z","timestamp":1417478487000},"page":"256-261","source":"Crossref","is-referenced-by-count":22,"title":["Etiologies of Acute Undifferentiated Fever and Clinical Prediction of Scrub Typhus in a Non-Tropical Endemic Area"],"prefix":"10.4269","volume":"92","author":[{"given":"Ho-Chul","family":"Jung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Bin","family":"Chon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won 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