{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T10:56:14Z","timestamp":1789815374574,"version":"4.0.1"},"reference-count":27,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,5,6]]},"abstract":"<jats:p>Leptospirosis is a neglected zoonosis caused by pathogenic <jats:italic>Leptospira<\/jats:italic>. In this study, we characterized the virulence of isolate B3-13S obtained from a wild mouse (<jats:italic>Mus musculus<\/jats:italic>) captured in New Caledonia, subsequently identified as a bacterium belonging to the <jats:italic>L. borgpetersenii<\/jats:italic> serogroup Ballum. Hamsters were infected with an intraperitoneal injection of 2 \u00d7 10<jats:sup>8<\/jats:sup> bacteria, resulting in severe histopathological organ damages consistent with tissue lesions previously observed with other strains. Hamsters were also injected with 1 \u00d7 10<jats:sup>8<\/jats:sup> or 5 \u00d7 10<jats:sup>7<\/jats:sup> bacteria and animals that recovered showed renal carriage of leptospires in concentrations similar to the bacterial load quantified in mouse kidneys, with urinary shedding of bacteria up to 4 weeks postinfection. The serogroup Ballum is increasingly reported in human leptospirosis, and these results highlight the use of the B3-13S isolate for the development of models resulting in either severe acute or chronic forms of the infection, allowing for better characterization of its pathogenesis.<\/jats:p>","DOI":"10.4269\/ajtmh.14-0462","type":"journal-article","created":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T02:53:20Z","timestamp":1426042400000},"page":"982-985","source":"Crossref","is-referenced-by-count":12,"title":["Experimental Hamster Infection with a Strain of Leptospira borgpetersenii Ballum Isolated from a Reservoir Mouse in New Caledonia"],"prefix":"10.4269","volume":"92","author":[{"given":"Mariko","family":"Matsui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Roche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Estelle","family":"Soup\u00e9-Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Roudier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Moniquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrille","family":"Goarant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Acta Trop","first-page":"176","article-title":"Rattus norvegicus as a model for persistent renal colonization by pathogenic Leptospira interrogans","volume":"105","author":"Athanazio","year":"2008"},{"key":"R2","series-title":"Vet Pathol","first-page":"792","article-title":"Host-pathogen interactions in the kidney during chronic leptospirosis","volume":"46","author":"Monahan","year":"2009"},{"key":"R3","series-title":"Lancet Infect Dis","first-page":"757","article-title":"Leptospirosis: a zoonotic disease of global importance","volume":"3","author":"Bharti","year":"2003"},{"key":"R4","series-title":"Med Mal Infect","first-page":"1","article-title":"Diagnosis and epidemiology of leptospirosis","volume":"43","author":"Picardeau","year":"2013"},{"key":"R5","series-title":"Epidemiol Infect","first-page":"1407","article-title":"Changes in epidemiology of leptospirosis in 2003\u20132004, a two El Nino Southern Oscillation period, Guadeloupe archipelago, French West Indies","volume":"136","author":"Herrmann-Storck","year":"2008"},{"key":"R6","series-title":"Epidemiol Infect","first-page":"29","article-title":"Changing epidemiology of human leptospirosis in New Zealand","volume":"128","author":"Thornley","year":"2002"},{"key":"R7","series-title":"Trop Med Int Health","first-page":"926","article-title":"Outbreak of leptospirosis in New Caledonia: diagnosis issues and burden of disease","volume":"14","author":"Goarant","year":"2009"},{"key":"R8","series-title":"PLoS Negl Trop Dis","first-page":"e1361","article-title":"Rodent abundance dynamics and leptospirosis carriage in an area of hyper-endemicity in New Caledonia","volume":"5","author":"Perez","year":"2011"},{"key":"R9","series-title":"Leptospira and Leptospirosis","author":"Faine","year":"1999"},{"key":"R10","series-title":"Revue fran\u00e7aise d'histotechnologie","first-page":"5","article-title":"Method of Warthin-Starry modified with pyrocatechol: interest for revealing spirochetes and infectious agents [M\u00e9thode de Warthin-Starry modifi\u00e9e au pyrocatechol: int\u00e9r\u00eat pour la mise en \u00e9vidence des spiroch\u00e8tes et agents infectieux]","volume":"6","author":"Wuscher","year":"1993"},{"key":"R11","series-title":"FEMS Microbiol Lett","first-page":"139","article-title":"A rapid and quantitative method for the detection of Leptospira species in human leptospirosis","volume":"249","author":"Merien","year":"2005"},{"key":"R12","series-title":"Am J Trop Med Hyg","first-page":"1032","article-title":"Leptospira and rodents in Cambodia: environmental determinants of infection","volume":"86","author":"Ivanova","year":"2012"},{"key":"R13","series-title":"Infect Immun","first-page":"4480","article-title":"Gene expression profiles of immune mediators and histopathological findings in animal models of leptospirosis: comparison between susceptible hamsters and resistant mice","volume":"79","author":"Matsui","year":"2011"},{"key":"R14","series-title":"Am J Trop Med Hyg","first-page":"271","article-title":"Highly virulent Leptospira borgpetersenii strain characterized in the hamster model","volume":"85","author":"Diniz","year":"2011"},{"key":"R15","series-title":"J Med Assoc Thai","first-page":"S178","article-title":"Alleviation of renal and pulmonary injury by immunomodulation in leptospirosis: hamster model","volume":"89","author":"Praditpornsilpa","year":"2006"},{"key":"R16","series-title":"Vet Pathol","first-page":"403","article-title":"Development of chronic and acute golden Syrian hamster infection models with Leptospira borgpetersenii serovar Hardjo","volume":"49","author":"Zuerner","year":"2012"},{"key":"R17","series-title":"PLoS ONE","first-page":"e32712","article-title":"Detection and quantification of Leptospira interrogans in hamster and rat kidney samples: immunofluorescent imprints versus real-time PCR","volume":"7","author":"Chagas-Junior","year":"2012"},{"key":"R18","series-title":"Vet Immunol Immunopathol","first-page":"546","article-title":"Development of tertiary lymphoid structures in the kidneys of pigs with chronic leptospiral nephritis","volume":"145","author":"Pezzolato","year":"2012"},{"key":"R19","series-title":"J Med Microbiol","first-page":"1101","article-title":"Different outcomes of experimental leptospiral infection in mouse strains with distinct genotypes","volume":"59","author":"Santos","year":"2010"},{"key":"R20","series-title":"Lab Anim","first-page":"300","article-title":"Leptospira interrogans serovar Sejroe infection in a group of laboratory dogs","volume":"29","author":"Scanziani","year":"1995"},{"key":"R21","series-title":"J Comp Pathol","first-page":"231","article-title":"Morphological alterations in the kidney of rats with natural and experimental Leptospira infection","volume":"137","author":"Tucunduva de Faria","year":"2007"},{"key":"R22","series-title":"J Vet Med A Physiol Pathol Clin Med","first-page":"441","article-title":"Immunoperoxidase and histopathological examinations of leptospiral nephritis in cattle","volume":"48","author":"Yener","year":"2001"},{"key":"R23","series-title":"Vaccine","first-page":"3892","article-title":"Characterization of virulence of Leptospira isolates in a hamster model","volume":"26","author":"Silva","year":"2008"},{"key":"R24","series-title":"J Wildl Dis","first-page":"318","article-title":"The distribution of leptospires in the kidney tubules of some British wild mammals","volume":"12","author":"Twigg","year":"1976"},{"key":"R25","series-title":"Int Microbiol","first-page":"35","article-title":"Cell aggregation: a mechanism of pathogenic Leptospira to survive in fresh water","volume":"7","author":"Trueba","year":"2004"},{"key":"R26","series-title":"Microbiology","first-page":"1309","article-title":"Biofilm formation by saprophytic and pathogenic leptospires","volume":"154","author":"Ristow","year":"2008"},{"key":"R27","series-title":"BMC Microbiol","first-page":"161","article-title":"Expression of sialic acids and other nonulosonic acids in Leptospira","volume":"12","author":"Ricaldi","year":"2012"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/92\/5\/article-p982.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/92\/5\/article-p982.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/92\/5\/article-p982.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T19:21:44Z","timestamp":1723058504000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/92\/5\/article-p982.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,6]]},"references-count":27,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.14-0462","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,6]]}}}