{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:19:39Z","timestamp":1759335579670},"reference-count":14,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3,4]]},"abstract":"<jats:p>Alveolar echinococcosis is the most serious helminthic zoonosis of the northern hemisphere affecting humans. The causative agent, <jats:italic>Echinococcus multilocularis<\/jats:italic>, occurs in geographically distinct strains that can be distinguished based on sequence variations of mitochondrial genes and nuclear microsatellite targets. This report finds that the human case of Alveolar echinococcosis occurring in Minnesota in 1977 was caused by the N2 haplotype described previously; the N2 haplotype is distinct from European and Asian isolates of the parasite and is restricted to the central region of North America.<\/jats:p>","DOI":"10.4269\/ajtmh.14-0484","type":"journal-article","created":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T05:30:41Z","timestamp":1416288641000},"page":"477-478","source":"Crossref","is-referenced-by-count":9,"title":["Demonstration That a Case of Human Alveolar Echinococcosis in Minnesota in 1977 was Caused by the N2 Strain"],"prefix":"10.4269","volume":"92","author":[{"given":"Claudia","family":"Klein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Massolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Clin Microbiol Rev","first-page":"107","article-title":"Biological, epidemiological, and clinical aspects of Echinococcosis, a zoonosis of increasing concern","volume":"17","author":"Eckert","year":"2004"},{"key":"R2","series-title":"PLoS Negl Trop Dis","first-page":"e722","article-title":"The global burden of alveolar echinococcosis","volume":"4","author":"Torgerson","year":"2010"},{"issue":"(Suppl 1)","key":"R3","series-title":"Parasitology","first-page":"S1","article-title":"Echinococcosis: transmission biology and epidemiology - Preface","volume":"127","author":"Craig","year":"2003"},{"key":"R4","series-title":"Parasitol Int","first-page":"384","article-title":"Geographic pattern of genetic variation in the fox tapeworm Echinococcus multilocularis","volume":"58","author":"Nakao","year":"2009"},{"key":"R5","series-title":"Infect Genet Evol","first-page":"3","article-title":"EmsB, a tandem repeated multi-loci microsatellite, new tool to investigate the genetic diversity of Echinococcus multilocularis","volume":"6","author":"Bart","year":"2006"},{"key":"R6","series-title":"Parasitology","first-page":"521","article-title":"Reduced genetic variability within coding and non-coding regions of the Echinococcus multilocularis genome","volume":"115","author":"Haag","year":"1997"},{"key":"R7","series-title":"Parasitology","first-page":"1133","article-title":"Establishment of a European-type strain of Echinococcus multilocularis in Canadian wildlife","volume":"140","author":"Gesy","year":"2013"},{"key":"R8","series-title":"Am J Trop Med Hyg","first-page":"1340","article-title":"Alveolar hydatid-disease: a review of clinical-features of 33 indigenous cases of Echinococcus multilocularis infection in Alaskan Eskimos","volume":"29","author":"Wilson","year":"1980"},{"key":"R9","series-title":"JAMA","first-page":"904","article-title":"Alveolar hydatid disease in Minnesota. First human case acquired in the contiguous United States","volume":"241","author":"Gamble","year":"1979"},{"article-title":"Biology and ecology of Echinococcus multilocularis: a public health concern at the interface between wildlife, domestic animals and humans?","year":"2013","author":"Kowalewska","key":"R10"},{"key":"R11","series-title":"Can Med Assoc J","first-page":"354","article-title":"Echinococcus alveolaris (with the report of a case)","volume":"36","author":"James","year":"1937"},{"key":"R12","series-title":"Am J Trop Med Hyg","first-page":"245","article-title":"Genetic analysis of Echinococcus multilocularis originating from a patient with alveolar echinococcosis occurring in Minnesota in 1977","volume":"79","author":"Yamasaki","year":"2008"},{"key":"R13","series-title":"Can Vet J","first-page":"870","article-title":"Alveolar hydatid disease (Echinococcus multilocularis) in the liver of a Canadian dog in British Columbia, a newly endemic region","volume":"53","author":"Peregrine","year":"2012"},{"key":"R14","series-title":"Can Vet J","first-page":"551","article-title":"Hepatic alveolar hydatid disease (Echinococcus multilocularis) in a boxer dog from southern Ontario","volume":"55","author":"Skelding","year":"2014"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/92\/3\/article-p477.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/92\/3\/article-p477.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/92\/3\/article-p477.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T19:28:12Z","timestamp":1723058892000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/92\/3\/article-p477.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,4]]},"references-count":14,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.14-0484","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"type":"print","value":"0002-9637"},{"type":"electronic","value":"1476-1645"}],"subject":[],"published":{"date-parts":[[2015,3,4]]}}}