{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:44:34Z","timestamp":1789533874098,"version":"build-2803163510"},"reference-count":104,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,2,3]]},"abstract":"<jats:p>Globally, scabies affects more than 130 million people at any time. In the developed world, outbreaks in health institutions and vulnerable communities result in a significant economic burden. A review of the literature demonstrates the emergence of resistance toward classical scabicidal treatments and the lack of effectiveness of currently available scabicides in reducing the inflammatory skin reactions and pyodermal progression that occurs in predisposed patient cohorts. Tea tree oil (TTO) has demonstrated promising acaricidal effects against scabies mites in vitro and has also been successfully used as an adjuvant topical medication for the treatment of crusted scabies, including cases that did not respond to standard treatments. Emerging acaricide resistance threatens the future usefulness of currently used gold standard treatments (oral ivermectin and topical permethrin) for scabies. The imminent development of new chemical entities is doubtful. The cumulative acaricidal, antibacterial, antipruritic, anti-inflammatory, and wound healing effects of TTO may have the potential to successfully reduce the burden of scabies infection and the associated bacterial complications. This review summarizes current knowledge on the use of TTO for the treatment of scabies. On the strength of existing data for TTO, larger scale, randomized controlled clinical trials are warranted.<\/jats:p>","DOI":"10.4269\/ajtmh.14-0515","type":"journal-article","created":{"date-parts":[[2016,1,20]],"date-time":"2016-01-20T04:38:13Z","timestamp":1453264693000},"page":"258-266","source":"Crossref","is-referenced-by-count":57,"title":["Therapeutic Potential of Tea Tree Oil for Scabies"],"prefix":"10.4269","volume":"94","author":[{"given":"Jackson","family":"Thomas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine F.","family":"Carson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg M.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley F.","family":"Walton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate A.","family":"Hammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Naunton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel C.","family":"Davey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Spelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Dettwiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Kyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle M.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavya E.","family":"Baby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Arch Dermatol","first-page":"563","article-title":"Acaricidal activity of Melaleuca alternifolia (tea tree) oil: in vitro sensitivity of Sarcoptes scabiei var hominis to terpinen-4-ol","volume":"140","author":"Walton","year":"2004"},{"key":"ref2","series-title":"Dermatol Ther","first-page":"279","article-title":"Scabies","volume":"22","author":"Hicks","year":"2009"},{"key":"ref3","series-title":"PLoS Negl Trop Dis","first-page":"e2167","article-title":"Toward the global control of human scabies: introducing the international alliance for the control of scabies","volume":"7","author":"Engelman","year":"2013"},{"key":"ref4","series-title":"Epidemiology and Management of Common Skin Diseases in Children in Developing Countries","author":"World Health Organization","year":"2005"},{"key":"ref5","series-title":"PLoS Negl Trop Dis","first-page":"e554","article-title":"A regional initiative to reduce skin infections amongst aboriginal children living in remote communities of the Northern Territory, Australia","volume":"3","author":"Andrews","year":"2009"},{"key":"ref6","series-title":"Curr Opin Infect Dis","first-page":"127","article-title":"Impact of scabies in resource-poor communities","volume":"26","author":"Heukelbach","year":"2013"},{"key":"ref7","series-title":"Trends Parasitol","first-page":"35","article-title":"Scratching the itch: new tools to advance understanding of scabies","volume":"29","author":"Mounsey","year":"2013"},{"key":"ref8","series-title":"N Engl J Med","first-page":"1718","article-title":"Clinical practices. 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Diseases","author":"The International Alliance for the Control of Scabies","year":"2014"},{"key":"ref101","series-title":"Diabetes Res Clin Pract","first-page":"65","article-title":"Topical phytochemicals used to salvage the gangrenous lower limbs of type 1 diabetic patients","volume":"62","author":"Sherry","year":"2003"},{"key":"ref102","series-title":"Wound Care","first-page":"317","article-title":"Two US practitioners' experience of using essential oils for wound care","volume":"11","author":"Hartman","year":"2002"},{"key":"ref103","series-title":"Tex Law Rev","first-page":"503","article-title":"Unpatentable drugs and the standards of patentability","volume":"87","author":"Roin","year":"2008"},{"key":"ref104","series-title":"Bull World Health Organ","first-page":"275","article-title":"Disease burden and health-care clinic attendances for young children in remote Aboriginal communities of northern Australia","volume":"86","author":"Clucas","year":"2008"}],"container-title":["The 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