{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:09:43Z","timestamp":1762430983426},"reference-count":21,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,5,6]]},"abstract":"<jats:p>The aim of this study was to determine the relationship between colonic symptoms, radiological abnormalities, and anorectal dysfunction in patients with Chagas disease. We performed a cross-sectional study of untreated patients diagnosed with Chagas disease. All patients were evaluated clinically (by a questionnaire for colonic symptoms based on Rome III criteria) and underwent a barium enema and anorectal manometry. A control group of patients with functional constipation and without Chagas disease was included in the study. Overall, 69 patients were included in the study: 42 patients were asymptomatic and 27 patients had abdominal symptoms according to Rome III criteria. Anorectal manometry showed a higher proportion of abnormalities in symptomatic patients than in asymptomatic ones (73% versus 21%, respectively; <jats:italic>P<\/jats:italic> &lt; 0.0001). Megarectum was detected in a similar proportion in the different subgroups regardless of the presence of symptoms or abnormalities in anorectal functions. Among non-Chagas disease patients with functional constipation, 90% had an abnormal anorectal manometry study. Patients with Chagas disease present a high proportion of constipation with dyssynergic defecation in anorectal manometry but a low prevalence of impaired rectoanal inhibitory reflex, although these abnormalities may be nonspecific for Chagas disease. The presence of megarectum is a nonspecific finding.<\/jats:p>","DOI":"10.4269\/ajtmh.14-0546","type":"journal-article","created":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T03:06:50Z","timestamp":1426561610000},"page":"898-902","source":"Crossref","is-referenced-by-count":8,"title":["Assessment of Rectocolonic Morphology and Function in Patients with Chagas Disease in Barcelona (Spain)"],"prefix":"10.4269","volume":"92","author":[{"given":"Fernando","family":"Salvador","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianela","family":"Mego","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adri\u00e1n","family":"S\u00e1nchez-Montalv\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Mor\u00eds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Accarino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan-Ramon","family":"Malagelada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Azpiroz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Israel","family":"Molina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"author":"World Health Organization","key":"R1","article-title":"Chagas disease (American trypanosomiasis)"},{"key":"R2","series-title":"Acta Trop","first-page":"14","article-title":"Chagas disease: a Latin American health problem becoming a world health problem","volume":"115","author":"Schmunis","year":"2010"},{"key":"R3","series-title":"Clin Microbiol Infect","first-page":"706","article-title":"Trypanosoma cruzi infection in a non-endemic country: epidemiological and clinical profile","volume":"20","author":"Salvador","year":"2014"},{"key":"R4","series-title":"Clin Microbiol Infect","first-page":"1108","article-title":"Chagas disease in Latin American migrants: a Spanish challenge","volume":"17","author":"P\u00e9rez-Ayala","year":"2011"},{"key":"R5","series-title":"Acta Trop","first-page":"51","article-title":"Clinical profile of Trypanosoma cruzi infection in a non-endemic setting: immigration and Chagas disease in Barcelona (Spain)","volume":"111","author":"Mu\u00f1oz","year":"2009"},{"key":"R6","series-title":"Mem Inst Oswaldo Cruz","first-page":"363","article-title":"Chagas disease morbidity. I- Study of cases originating in various states of Brazil, observed in Rio de Janeiro","volume":"78","author":"Coura","year":"1983"},{"key":"R7","series-title":"Am J Trop Med Hyg","first-page":"539","article-title":"The epidemiology of Chagas' disease in a hyperendemic area of Cochabamba, Bolivia: a clinical study including electrocardiography, seroreactivity to Trypanosoma cruzi, xenodiagnosis, and domiciliary triatomine distribution","volume":"47","author":"Pless","year":"1992"},{"key":"R8","series-title":"Am J Trop Med Hyg","first-page":"521","article-title":"Chagas' disease in Bolivia: clinical and epidemiological features and zymodeme variability of Trypanosoma cruzi strains isolated from patients","volume":"41","author":"Breni\u00e8re","year":"1989"},{"key":"R9","series-title":"Mem Inst Oswaldo Cruz","first-page":"733","article-title":"Clinical forms of Trypanosoma cruzi infected individuals in the chronic phase of Chagas disease in Puebla, Mexico","volume":"101","author":"S\u00e1nchez-Guill\u00e9n","year":"2006"},{"key":"R10","series-title":"Lancet Infect Dis","first-page":"556","article-title":"Chagas disease: changes in knowledge and management","volume":"10","author":"Lescure","year":"2010"},{"key":"R11","series-title":"Am J Trop Med Hyg","first-page":"412","article-title":"Identification of a Western blot pattern for the specific diagnosis of Trypanosoma cruzi infection in human sera","volume":"86","author":"Riera","year":"2012"},{"series-title":"Rome III Diagnostic Criteria for Functional Gastrointestinal Disorders","key":"R12"},{"key":"R13","series-title":"Rev Soc Bras Med Trop","first-page":"23","article-title":"Tecnica simplificada para o diagn\u00f3stico radiol\u00f3gico do megacolo chag\u00e1sico","volume":"17","author":"Ximenes","year":"1984"},{"key":"R14","series-title":"Ann Trop Med Parasitol","first-page":"25","article-title":"Gastro-intestinal Chagas disease in migrants to Spain: prevalence and methods for early diagnosis","volume":"105","author":"P\u00e9rez-Ayala","year":"2011"},{"key":"R15","series-title":"Am J Gastroenterol","first-page":"884","article-title":"Gastrointestinal manifestations of Chagas disease","volume":"93","author":"De Oliveira","year":"1998"},{"key":"R16","series-title":"Braz J Med Biol Res","first-page":"255","article-title":"Chagas disease: a model of denervation in the study of digestive tract motility","volume":"18","author":"Meneghelli","year":"1985"},{"key":"R17","series-title":"Arq Gastroenterol","first-page":"127","article-title":"Basal motility of dilated and non-dilated sigmoid colon and rectum in Chagas disease","volume":"19","author":"Meneghelli","year":"1982"},{"key":"R18","series-title":"Arq Gastroenterol","first-page":"128","article-title":"Prevalence of rectoanal inhibitory reflex in chagasic megacolon","volume":"45","author":"Cavenaghi","year":"2008"},{"key":"R19","series-title":"Dis Colon Rectum","first-page":"1387","article-title":"Rectosigmoidectomy with ileal loop interposition: a new surgical method for the treatment of chagasic megacolon","volume":"45","author":"Netinho","year":"2002"},{"key":"R20","series-title":"Am J Surg Pathol","first-page":"460","article-title":"The enteric nervous system in chagasic and idiopathic megacolon","volume":"31","author":"Iantorno","year":"2007"},{"key":"R21","series-title":"Dig Dis Sci","first-page":"2877","article-title":"Neurochemical coding of the enteric nervous system in chagasic patients with megacolon","volume":"52","author":"Da Silveira","year":"2007"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/92\/5\/article-p898.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/92\/5\/article-p898.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/92\/5\/article-p898.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T19:21:53Z","timestamp":1723058513000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/92\/5\/article-p898.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,6]]},"references-count":21,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.14-0546","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"type":"print","value":"0002-9637"},{"type":"electronic","value":"1476-1645"}],"subject":[],"published":{"date-parts":[[2015,5,6]]}}}