{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T19:49:36Z","timestamp":1791748176585,"version":"4.3.4"},"reference-count":20,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3,4]]},"abstract":"<jats:p>Although meningitis secondary to chronic strongyloidiasis is a rare complication, it is associated with a high mortality rate. Recurrent meningitis can occur if the underlying parasitic infection is left untreated. We report five cases of recurrent meningitis related to chronic strongyloidiasis that were associated with human T-lymphotropic virus type 1 (HTLV-1) infection. Common causative organisms are <jats:italic>Escherichia coli<\/jats:italic>, <jats:italic>Streptococcus bovis<\/jats:italic>, and <jats:italic>Klebsiella pneumonia<\/jats:italic>. One patient died during the second episode of meningitis. Three patients showed significant gastrointestinal and respiratory symptoms before developing headache and fever. In four cases, patients developed multiple recurrences even with the treatment of thiabendazol. Ivermectin seems to be a better agent compared with thiabendazol to achieve eradication of strongyloidiasis.<\/jats:p>","DOI":"10.4269\/ajtmh.14-0564","type":"journal-article","created":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T09:14:19Z","timestamp":1419930859000},"page":"601-604","source":"Crossref","is-referenced-by-count":15,"title":["Five Cases of Recurrent Meningitis Associated with Chronic Strongyloidiasis"],"prefix":"10.4269","volume":"92","author":[{"given":"Teppei","family":"Shimasaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heath","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichi","family":"Shiiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Clin Infect Dis","first-page":"e46","article-title":"Community-acquired recurrent bacterial meningitis in adults","volume":"45","author":"Adriani","year":"2007"},{"key":"R2","series-title":"Curr Opin Infect Dis","first-page":"458","article-title":"Screening, prevention, and treatment for hyperinfection syndrome and disseminated infections caused by Strongyloides stercoralis","volume":"25","author":"Mejia","year":"2012"},{"key":"R3","series-title":"Clin Mol Allergy","first-page":"8","article-title":"Intestinal strongyloidiasis and hyperinfection syndrome","volume":"4","author":"Vadlamudi","year":"2006"},{"key":"R4","series-title":"Clin Microbiol Rev","first-page":"208","article-title":"Strongyloides stercoralis in the immunocompromised population","volume":"17","author":"Keiser","year":"2004"},{"key":"R5","series-title":"Eur J Intern Med","first-page":"e42","article-title":"Fatal recurrent bacterial meningitis: a complication of chronic Strongyloides infection","volume":"19","author":"Somin","year":"2008"},{"key":"R6","series-title":"South Med J","first-page":"728","article-title":"Bacterial complications of strongyloidiasis: Streptococcus bovis meningitis","volume":"92","author":"Link","year":"1999"},{"key":"R7","series-title":"PLoS Negl Trop Dis","first-page":"e2288","article-title":"Strongyloides stercoralis: global distribution and risk factors","volume":"7","author":"Sch\u00e4r","year":"2013"},{"key":"R8","series-title":"Clin Infect Dis","first-page":"1040","article-title":"Diagnosis of Strongyloides stercoralis infection","volume":"33","author":"Siddiqui","year":"2001"},{"key":"R9","series-title":"Arch Intern Med","first-page":"1257","article-title":"Clinical and epidemiologic features of strongyloidiasis. 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