{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:31:27Z","timestamp":1791235887933,"version":"4.1.0"},"reference-count":24,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3,4]]},"abstract":"<jats:p>Antimalarial drugs are a key tool in malaria elimination programs. With the emergence of artemisinin resistance in southeast Asia, an effort to identify molecular markers for surveillance of resistant malaria parasites is underway. Non-synonymous mutations in the kelch propeller domain (K13-propeller) in <jats:italic>Plasmodium falciparum<\/jats:italic> have been associated with artemisinin resistance in samples from southeast Asia, but additional studies are needed to characterize this locus in other <jats:italic>P. falciparum<\/jats:italic> populations with different levels of artemisinin use. Here, we sequenced the K13-propeller locus in 82 samples from Haiti, where limited government oversight of non-governmental organizations may have resulted in low-level use of artemisinin-based combination therapies. We detected a single-nucleotide polymorphism (SNP) at nucleotide 1,359 in a single isolate. Our results contribute to our understanding of the global genomic diversity of the K13-propeller locus in <jats:italic>P. falciparum<\/jats:italic> populations.<\/jats:p>","DOI":"10.4269\/ajtmh.14-0664","type":"journal-article","created":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T02:58:31Z","timestamp":1422932311000},"page":"552-554","source":"Crossref","is-referenced-by-count":16,"title":["Artemisinin Resistance-Associated Polymorphisms at the K13-Propeller Locus are Absent in Plasmodium falciparum Isolates from Haiti"],"prefix":"10.4269","volume":"92","author":[{"given":"Tamar E.","family":"Carter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Boulter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Existe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean R.","family":"Romain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Yves","family":"St. Victor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie J.","family":"Mulligan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard A.","family":"Okech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"World Malaria Report 2013","author":"World Health Organization","year":"2014"},{"key":"R2","series-title":"N Engl J Med","first-page":"2619","article-title":"Evidence of artemisinin-resistant malaria in western Cambodia","volume":"359","author":"Noedl","year":"2008"},{"key":"R3","series-title":"N Engl J Med","first-page":"455","article-title":"Artemisinin resistance in Plasmodium falciparum 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Haiti\u20132010","volume":"86","author":"Townes","year":"2012"},{"key":"R13","series-title":"PLoS ONE","first-page":"e93684","article-title":"Serological measures of malaria transmission in Haiti: comparison of longitudinal and cross-sectional methods","volume":"9","author":"Arnold","year":"2014"},{"key":"R14","series-title":"Malar J","first-page":"361","article-title":"Age-specific malaria seroprevalence rates: a cross-sectional analysis of malaria transmission in the Ouest and Sud-Est departments of Haiti","volume":"13","author":"von Fricken","year":"2014"},{"key":"R15","series-title":"Malar J","first-page":"426","article-title":"Survey of Plasmodium falciparum multidrug resistance-1 and chloroquine resistance transporter alleles in Haiti","volume":"12","author":"Elbadry","year":"2013"},{"key":"R16","series-title":"Emerg Infect Dis","first-page":"1487","article-title":"Lack of evidence for chloroquine-resistant Plasmodium falciparum malaria, Leogane, 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PfATPase6","volume":"366","author":"Jambou","year":"2005"},{"key":"R21","series-title":"Antimicrob Agents Chemother","first-page":"2546","article-title":"Lack of association of the S769N mutation in Plasmodium falciparum SERCA (PfATP6) with resistance to artemisinins","volume":"56","author":"Cui","year":"2012"},{"key":"R22","series-title":"PLoS ONE","first-page":"e59192","article-title":"Genetic diversity and lack of artemisinin selection signature on the Plasmodium falciparum ATP6 in the Greater Mekong Subregion","volume":"8","author":"Miao","year":"2013"},{"key":"R23","series-title":"Med Sante Trop","first-page":"435","article-title":"Prevalence of Plasmodium falciparum during the rainy season (June\u2013December) in the southeast district of Haiti","volume":"22","author":"Raccurt","year":"2012"},{"key":"R24","series-title":"Bull Soc Pathol Exot","article-title":"Gametocyte carriage in asymptomatic Plasmodium falciparum infections in Haiti 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