{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:35:52Z","timestamp":1789878952613,"version":"4.0.1"},"reference-count":45,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,9,2]]},"abstract":"<jats:p><jats:italic>Leishmania<\/jats:italic> parasites isolated, between 1979 and 1988 by the late Bryce Walton, from Dominican Republic (DR) patients with diffuse cutaneous leishmaniasis, were characterized using a panel of 12 isoenzymes, 23 monoclonal antibodies, small subunit ribosomal DNA (SSu rDNA), and multilocus sequence analysis (MLSA). The isoenzyme and monoclonal antibody profiles and the MLSA results showed that the Dominican Republic parasites were distinct from other described <jats:italic>Leishmania<\/jats:italic> species. This new species belongs to the <jats:italic>mexicana<\/jats:italic> complex, which is distributed in central and parts of northern South America. It is suggested that the parasites uniqueness from other members of the <jats:italic>mexicana<\/jats:italic> complex is related to it being isolated on an island for millions of years. If <jats:italic>Leishmania<\/jats:italic> (<jats:italic>Leishmania<\/jats:italic>) <jats:italic>waltoni<\/jats:italic> fails to adapt to some imported mammal, such as the house rat, it will be the only <jats:italic>Leishmania<\/jats:italic> to be classified as an endangered species. The excessive destruction of habitats on Hispaniola threatens the survival of its vectors and presumed natural reservoirs, such as the rodent hutias and the small insectivorous mammal solenodon. The concept of <jats:italic>Leishmania<\/jats:italic> species is discussed in the light of recent evaluations on criteria for defining bacterial species.<\/jats:p>","DOI":"10.4269\/ajtmh.14-0774","type":"journal-article","created":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T02:09:49Z","timestamp":1436234989000},"page":"552-558","source":"Crossref","is-referenced-by-count":27,"title":["Characterization of Leishmania (Leishmania) waltoni n.sp. (Kinetoplastida: Trypanosomatidae), the Parasite Responsible for Diffuse Cutaneous Leishmaniasis in the Dominican Republic"],"prefix":"10.4269","volume":"93","author":[{"given":"Jeffrey","family":"Shaw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Pratlong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucile","family":"Floeter-Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edna","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fouad","family":"El Baidouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Ravel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Dedet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Topley and Wilson's Microbiology and Microbial Infections","first-page":"313","article-title":"17 New World leishmaniasis","author":"Lainson","year":"2005"},{"key":"ref2","series-title":"Revista Dominicana de Dermatologia","first-page":"19","article-title":"Leishmaniasis tegumentaria Americana. 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