{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:15:23Z","timestamp":1790270123650,"version":"4.1.0"},"reference-count":10,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,10,7]]},"abstract":"<jats:p>Cutaneous leishmaniasis (CL) is diverse in its clinical presentation but usually demonstrates an erythematous, infiltrated, ulcerated, and crusted papule or nodule in exposed areas of the body. Rare clinical features have been reported including lymphatic dissemination, usually with subcutaneous nodules along lymphatic channels. Herein, we present six patients suffering from Old World CL with lymphatic dissemination characterized by sporotrichoid subcutaneous nodules along the lymphatic channels draining the primary lesion. Patients' history, clinical and laboratory findings were collected and summarized. Lymphatic dissemination of CL in our patients manifested as subcutaneous nodules without epidermal involvement within the axis of lymphatic drainage toward the regional lymph node, at times accompanied by regional lymphadenopathy. In all patients, the lymphatic dissemination was not present at initial diagnosis of CL, appearing only after local (topical or intralesional) treatment was initiated. In three patients, the subcutaneous nodules resolved without systemic treatment. Lymphatic dissemination of Old World CL is not uncommon and may possibly be triggered by local treatment. It should be recognized by dermatologists, especially those working in endemic areas. Systemic treatment may be not necessary since spontaneous resolution may occur.<\/jats:p>","DOI":"10.4269\/ajtmh.14-0787","type":"journal-article","created":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T02:10:23Z","timestamp":1439863823000},"page":"770-773","source":"Crossref","is-referenced-by-count":16,"title":["Lymphatic Dissemination in Cutaneous Leishmaniasis Following Local Treatment"],"prefix":"10.4269","volume":"93","author":[{"given":"Elena","family":"Thomaidou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liran","family":"Horev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Jotkowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Zamir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arieh","family":"Ingber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claes D.","family":"Enk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vered","family":"Molho-Pessach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Dermatol Online J","first-page":"4","article-title":"Clinical spectrum of cutaneous leishmaniasis: an overview from Pakistan","volume":"18","author":"Bari","year":"2012"},{"key":"ref2","series-title":"Br J Dermatol","first-page":"861","article-title":"Can a simple outpatient-based treatment be used to treat cutaneous leishmaniasis in young children? A critically appraised topic","volume":"172","author":"Burden-Teh","year":"2015"},{"key":"ref3","series-title":"J Eur Acad Dermatol Venereol","first-page":"973","article-title":"Liposomal amphotericin B treatment of cutaneous leishmaniasis due to Leishmania tropica","volume":"25","author":"Solomon","year":"2011"},{"key":"ref4","series-title":"J R Army Med Corps","first-page":"225","article-title":"Outbreak of zoonotic cutaneous leishmaniasis with local dissemination in Balkh, Afghanistan","volume":"158","author":"Bailey","year":"2012"},{"key":"ref5","series-title":"J Am Acad Dermatol","first-page":"759","article-title":"Sporotrichoid leishmaniasis in patients from Saudi Arabia: clinical and histologic features","volume":"17","author":"Kibbi","year":"1987"},{"key":"ref6","series-title":"Ann Dermatol Venereol","first-page":"63","article-title":"Sporotrichoid cutaneous leishmaniasis in Tunisia: a clinical and histological study","volume":"135","author":"Masmoudi","year":"2008"},{"key":"ref7","series-title":"Int J Dermatol","first-page":"300","article-title":"Dissemination in cutaneous leishmaniasis. I. Subcutaneous nodules","volume":"26","author":"Kubba","year":"1987"},{"key":"ref8","series-title":"Diagn Microbiol Infect Dis","first-page":"349","article-title":"PCR diagnosis and characterization of Leishmania in local and imported clinical samples","volume":"47","author":"Schonian","year":"2003"},{"key":"ref9","series-title":"Int J Dermatol","first-page":"132","article-title":"Clinical manifestations and classification of Old World cutaneous leishmaniasis","volume":"46","author":"Akilov","year":"2007"},{"key":"ref10","series-title":"Ann Trop Med Parasitol","first-page":"33","article-title":"Possible mechanisms of action of the compounds injected intralesionally in the treatment of cutaneous leishmaniasis, in addition to their direct effects on the parasites","volume":"100","author":"Najim","year":"2006"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/93\/4\/article-p770.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/93\/4\/article-p770.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/93\/4\/article-p770.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T19:01:27Z","timestamp":1723057287000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/93\/4\/article-p770.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,7]]},"references-count":10,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.14-0787","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,7]]}}}