{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:28:44Z","timestamp":1789036124382,"version":"build-2803163510"},"reference-count":44,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,11,4]]},"abstract":"<jats:p>Little is known about the type and longevity of the humoral response to cryptosporidial infections in developing countries. We evaluated serum antibody response to <jats:italic>Cryptosporidium<\/jats:italic> gp15 in 150 sets of maternal, preweaning and postinfection\/end-of-follow-up sera from children followed up to 2 years of age to determine the influence of maternal and preweaning serological status on childhood cryptosporidiosis. Fifty two percent (<jats:italic>N<\/jats:italic> = 78) of mothers and 20% (<jats:italic>N<\/jats:italic> = 30) of children were seropositive preweaning. However, most positive preweaning samples from children were collected early in life indicating transplacental transfer and subsequent rapid waning of antibodies. Although 62% (<jats:italic>N<\/jats:italic> = 94) of children had a parasitologically confirmed cryptosporidial infection (detected by stool polymerase chain reaction) during the follow-up, only 54% (<jats:italic>N<\/jats:italic> = 51) of children were seropositive postinfection. Given there were striking differences in seropositivity depending on when the sample was collected, even though <jats:italic>Cryptosporidium<\/jats:italic> was detected in the stool of the majority of the children, this study indicates that antibodies wane rapidly. During follow-up, the acquisition or severity of cryptosporidial infections was not influenced by maternal (<jats:italic>P<\/jats:italic> = 0.331 and 0.720, respectively) as well as the preweaning serological status of the child (<jats:italic>P<\/jats:italic> = 0.076 and 0.196, respectively).<\/jats:p>","DOI":"10.4269\/ajtmh.15-0044","type":"journal-article","created":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T01:50:21Z","timestamp":1440467421000},"page":"931-938","source":"Crossref","is-referenced-by-count":8,"title":["Serum Anti-Cryptosporidial gp15 Antibodies in Mothers and Children Less than 2 Years of Age in India"],"prefix":"10.4269","volume":"93","author":[{"given":"Robin P.","family":"Lazarus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sitara S. R.","family":"Ajjampur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayanthy C.","family":"Geetha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok D.","family":"Prabakaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasanth","family":"Velusamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena N.","family":"Naumova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honorine D.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gagandeep","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Emerg Infect Dis","first-page":"607","article-title":"Food-related illness and death in the United States","volume":"5","author":"Mead","year":"1999"},{"key":"ref2","series-title":"Int J Parasitol","first-page":"1305","article-title":"Epidemiology of Cryptosporidium: transmission, detection and identification","volume":"30","author":"Fayer","year":"2000"},{"key":"ref3","series-title":"Lancet","first-page":"209","article-title":"Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control 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Fortaleza, Brazil","volume":"51","author":"Zu","year":"1994"}],"container-title":["The American Society of Tropical Medicine and 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