{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:23:50Z","timestamp":1791285830243,"version":"4.1.0"},"reference-count":41,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,9,2]]},"abstract":"<jats:p>Large parts of African and American countries are colonized by <jats:italic>Mansonella<\/jats:italic>, a very common but poorly described filarial nematode. Bloodsucking flies of the genus <jats:italic>Culicoides<\/jats:italic> are suspected to be the vector of <jats:italic>Mansonella perstans<\/jats:italic>, but no study in Senegal has confirmed that <jats:italic>Culicoides<\/jats:italic> can transmit the parasite. Designed specific real-time quantitative polymerase chain reaction (qPCR) can be used to identify microfilaria in stained blood smears. This study was performed in July and December 2010 in the southeastern Senegal, which is known to be endemic for <jats:italic>M. perstans<\/jats:italic>. We analyzed 297 blood smears from febrile and afebrile resident people by qPCR. The global prevalence of <jats:italic>M. perstans<\/jats:italic> was approximately 14.5% in both febrile and afebrile individuals. The age group of &gt; 30 years had the highest prevalence (22.0%). No <jats:italic>Culicoides<\/jats:italic> among 1,159 studied specimens was positive for <jats:italic>M. perstans<\/jats:italic> and its vector in Senegal still requires identification.<\/jats:p>","DOI":"10.4269\/ajtmh.15-0051","type":"journal-article","created":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T02:06:36Z","timestamp":1434420396000},"page":"601-606","source":"Crossref","is-referenced-by-count":39,"title":["High Prevalence of Mansonella perstans Filariasis in Rural Senegal"],"prefix":"10.4269","volume":"93","author":[{"given":"Hubert","family":"Bassene","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masse","family":"Sambou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Fenollar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si\u00e2n","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sawdiatou","family":"Djiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00ebl","family":"Mourembou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alioune Badara","family":"L. 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Faso","volume":"47","author":"Gbary","year":"1987"},{"key":"ref4","series-title":"Parassitologia","first-page":"23","article-title":"Mansonella perstans filariasis","volume":"49","author":"Bregani","year":"2007"},{"key":"ref5","series-title":"Adv Parasitol","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0065-308X(03)53004-4","article-title":"Diagnosis of human filariases (except onchocerciasis)","volume":"53","author":"Walther","year":"2003"},{"key":"ref6","series-title":"Acta Otorrinolaringol Esp","first-page":"145","article-title":"Mansonella perstans isolated on aspiration puncture of a salivary gland","volume":"59","author":"Mateu","year":"2008"},{"key":"ref7","series-title":"Arq Bras Oftalmol","first-page":"167","article-title":"Ocular manifestations in mansonelliasis","volume":"71","author":"Cohen","year":"2008"},{"key":"ref8","series-title":"Am J Trop Med Hyg","first-page":"553","article-title":"Nodules in the conjunctiva, bung-eye, and bulge-eye in Africa caused by Mansonella perstans","volume":"38","author":"Baird","year":"1988"},{"key":"ref9","series-title":"Oncol Rep","first-page":"1597","article-title":"Dextran sulfate sodium administered orally is depolymerized in the stomach and induces cell cycle arrest plus apoptosis in the colon in early mouse colitis","volume":"28","author":"Araki","year":"2012"},{"key":"ref10","series-title":"Parasitol Res","first-page":"945","article-title":"Analysis of the 24-h microfilarial periodicity of Mansonella perstans","volume":"104","author":"Asio","year":"2009"},{"key":"ref11","series-title":"J Infect Dis","first-page":"1318","article-title":"Loiasis in endemic and nonendemic populations: immunologically mediated differences in clinical presentation","volume":"163","author":"Klion","year":"1991"},{"key":"ref12","series-title":"Travel Med Infect Dis","first-page":"275","article-title":"Mansonella perstans causing symptomatic hypereosinophilia in a missionary family","volume":"4","author":"Fux","year":"2006"},{"key":"ref13","series-title":"Trans R Soc Trop Med Hyg","first-page":"70","article-title":"Development of Microfilaria perstans in Culicoides grahami; a preliminary note","volume":"27","author":"Sharp","year":"1927"},{"key":"ref14","series-title":"Trans R Soc Trop Med Hyg","first-page":"371","article-title":"Filaria perstans; its development in Culicoides austeni","volume":"21","author":"Sharp","year":"1928"},{"key":"ref15","series-title":"Ann Trop Med Parasitol","first-page":"165","article-title":"Notes on the biology of certain Culicoides studied in the British Cameroons, west Africa, together with observations on their possible role as vectors of Acanthocheilonema perstans","volume":"46","author":"Hopkins","year":"1952"},{"key":"ref16","series-title":"Ann Trop Med Parasitol","first-page":"276","article-title":"Culicoides austeni, the vector of Acanthocheilonema perstans","volume":"46","author":"Hopkins","year":"1952"},{"key":"ref17","series-title":"Cent Afr J Med","first-page":"1","article-title":"Filariasis: Dipetalonema perstans infections in Rhodesia","volume":"17","author":"Clarke","year":"1971"},{"key":"ref18","series-title":"Ann Trop Med Parasitol","first-page":"251","article-title":"Epidemiology of Mansonella perstans filariasis in the forest region of south Congo","volume":"84","author":"Noireau","year":"1990"},{"key":"ref19","series-title":"Korean J Parasitol","first-page":"67","article-title":"Biting of anthropophilic Culicoides fulvithorax (Diptera: Ceratopogonidae), a vector of Mansonella perstans in Nigeria","volume":"44","author":"Agbolade","year":"2006"},{"key":"ref20","series-title":"Trans R Entomol Soc Lond","first-page":"1","article-title":"The Culicoides latreille (Diptera: Ceratopogonidae) of east Africa","volume":"123","author":"Khamala","year":"1971"},{"key":"ref21","series-title":"Bull Soc Pathol Exot","first-page":"408","article-title":"R\u00e9sultats d'une enqu\u00eate sur les porteurs de microfilaire en Afrique Occidentale Fran\u00e7aise","volume":"47","author":"Pfister","year":"1954"},{"key":"ref22","series-title":"Bull Soc Med Afr Noire Lang Fr","first-page":"398","article-title":"Contribution a l'etude de la repartition des filarioses humaines au Senegal: enquetes dans la region de Damantan (Senegal oriental) et la Region cotiere de Casamance","volume":"9","author":"Hocquet","year":"1964"},{"key":"ref23","series-title":"PLoS Negl Tropical Dis","first-page":"1","article-title":"Point-of-care laboratory of pathogen diagnosis in rural Senegal","volume":"7","author":"Sokhna","year":"2013"},{"key":"ref24","series-title":"Med Microbiol Immunol (Berl)","first-page":"15","article-title":"Epidemiology of concomitant infections due to Loa loa, Mansonella perstans, and Onchocerca volvulus in rain forest villages of Cameroon","volume":"192","author":"Wanji","year":"2003"},{"key":"ref25","series-title":"Lancet Infect Dis","first-page":"476","article-title":"The rise and fall of malaria in a west African rural community, Dielmo, Senegal, from 1990 to 2012: a 22 year longitudinal study","volume":"14","author":"Trape","year":"2014"},{"key":"ref26","series-title":"PLoS One","first-page":"e87169","article-title":"A 20-year longitudinal study of Plasmodium ovale and Plasmodium malariae prevalence and morbidity in a west African population","volume":"9","author":"Roucher","year":"2014"},{"key":"ref27","series-title":"Mosq News","first-page":"126","article-title":"Battery light trap, an improved model","volume":"22","author":"Sudia","year":"1962"},{"key":"ref28","series-title":"Bull Soc Entomol Fr","first-page":"149","article-title":"R\u00e9visions des esp\u00e8ces de Culicoides apparent\u00e9es \u00e0 C. schultzei (Enderlein, 1908) dans la r\u00e9gion afrotropicale (Diptera, Ceratopogonidae)","volume":"99","author":"Cornet","year":"1994"},{"key":"ref29","series-title":"J Med Entomol","first-page":"85","article-title":"Culicoides biting midges (Diptera: Ceratopogonidae) of Kenya","volume":"27","author":"Glick","year":"1990"},{"key":"ref30","series-title":"Cah ORSTOM, s\u00e9r Ent m\u00e9d Parasitol","first-page":"341","article-title":"Les Culicoides (Diptera Ceratopogonidae) de l'Ouest africain (1\u00e8re note)","volume":"VII","author":"Cornet","year":"1969"},{"key":"ref31","series-title":"Ticks Tick Borne Dis","first-page":"552","article-title":"Identification of rickettsial pathogens in ixodid ticks in northern Senegal","volume":"5","author":"Sambou","year":"2014"},{"key":"ref32","series-title":"Emerg Infect Dis","first-page":"1140","article-title":"Rickettsia felis-associated uneruptive fever, Senegal","volume":"16","author":"Socolovschi","year":"2010"},{"key":"ref33","series-title":"Mol Biochem Parasitol","first-page":"123","article-title":"Molecular identification of Wolbachia from the filarial nematode Mansonella perstans","volume":"160","author":"Keiser","year":"2008"},{"key":"ref34","series-title":"Am J Trop Med Hyg","first-page":"1167","article-title":"Epidemiologic survey of Mansonella ozzardi in Corail, Haiti","volume":"90","author":"Raccurt","year":"2014"},{"key":"ref35","series-title":"Am J Trop Med Hyg","first-page":"191","article-title":"Quantitative real-time polymerase chain reaction for malaria diagnosis and its use in malaria vaccine clinical trials","volume":"73","author":"Andrews","year":"2005"},{"key":"ref36","series-title":"Emerg Infect Dis","first-page":"883","article-title":"Tick-borne relapsing fever borreliosis, rural Senegal","volume":"17","author":"Parola","year":"2011"},{"key":"ref37","series-title":"Ann Trop Med Parasitol","first-page":"251","article-title":"Epidemiology of Mansonella perstans filariasis in the forest region of south Congo","volume":"84","author":"Noireau","year":"1990"},{"key":"ref38","series-title":"Trans R Soc Trop Med Hyg","first-page":"371","article-title":"Filaria perstans; its development in Culicoides austeni","volume":"21","author":"Sharp","year":"1928"},{"key":"ref39","series-title":"Jpn J Infect Dis","first-page":"108","article-title":"Loa loa and Mansonella perstans infections in Ijebu North, western Nigeria: a parasitological study","volume":"54","author":"Agbolade","year":"2001"},{"key":"ref40","series-title":"Ann Trop Med Parasitol","first-page":"165","article-title":"Notes on the biology of certain Culicoides studied in the British Cameroons, west Africa, together with observations on their possible role as vectors of Acanthocheilonema perstans","volume":"46","author":"Hopkins","year":"1952"},{"key":"ref41","series-title":"Ann Trop Med Parasitol","first-page":"276","article-title":"Culicoides austeni, the vector of Acanthocheilonema 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