{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:36:23Z","timestamp":1789749383178,"version":"4.0.1"},"reference-count":19,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,6]]},"abstract":"<jats:p>Knowledge of variables influencing serology is crucial to evaluate serology results for the diagnosis and clinical management of cystic echinococcosis (CE). We analyzed retrospectively a cohort of patients with hepatic CE followed in our clinic in 2000\u20132012 to evaluate the influence of several variables on the results of commercial enzyme-linked immunosorbent assay (ELISA) and indirect hemagglutination (IHA) tests. Sera from 171 patients with \u2265 1 hepatic CE cyst, and 90 patients with nonparasitic cysts were analyzed. CE cysts were staged according to the WHO-IWGE classification and grouped by activity. A significant difference in ELISA optical density (OD) values and percentage of positivity was found among CE activity groups and with controls (<jats:italic>P<\/jats:italic> &lt; 0.001). The serological response was also influenced by age (<jats:italic>P<\/jats:italic> &lt; 0.001) and cyst number (<jats:italic>P<\/jats:italic> = 0.003). OD values and cyst size were positively correlated in active cysts (<jats:italic>P<\/jats:italic> = 0.001). IHA test showed comparable results. When we analyzed the results of 151 patients followed over time, we found that serology results were significantly influenced by cyst activity, size, number, and treatment \u2264 12 months before serum collection. In conclusion, serological responses as assessed by commercial tests depend on CE cyst activity, size and number, and time from treatment. Clinical studies and clinicians in their practice should take this into account.<\/jats:p>","DOI":"10.4269\/ajtmh.15-0219","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T01:53:37Z","timestamp":1445910817000},"page":"166-171","source":"Crossref","is-referenced-by-count":67,"title":["Factors Influencing the Serological Response in Hepatic Echinococcus granulosus Infection"],"prefix":"10.4269","volume":"94","author":[{"given":"Raffaella","family":"Lissandrin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Tamarozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Piccoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Tinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"De 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Hyg","first-page":"301","article-title":"Clinical management of cystic echinococcosis: state of the art, problems, and perspectives","volume":"79","author":"Junghanss","year":"2008"},{"key":"ref8","series-title":"NMR Biomed","first-page":"734","article-title":"Metabolic viability assessment of cystic echinococcosis using high-field 1H MRS of cyst contents","volume":"21","author":"Hosch","year":"2008"},{"key":"ref9","series-title":"Acta Trop","first-page":"74","article-title":"Antigens for the immunodiagnosis of Echinococcus granulosus infection: an update","volume":"98","author":"Carmena","year":"2006"},{"key":"ref10","series-title":"PLoS Negl Trop Dis","first-page":"e1714","article-title":"Improved serodiagnosis of cystic echinococcosis using the new recombinant 2B2t antigen","volume":"6","author":"Hernandez-Gonzalez","year":"2012"},{"key":"ref11","series-title":"J Clin Microbiol","first-page":"1631","article-title":"Assessment of Echinococcus granulosus somatic protoscolex antigens for serological follow-up of young patients surgically treated for cystic echinococcosis","volume":"46","author":"Ben Nouir","year":"2008"},{"key":"ref12","series-title":"Clin Vaccine Immunol","first-page":"470","article-title":"Specific IgG responses to recombinant antigen B and em18 in cystic and alveolar echinococcosis in China","volume":"17","author":"Li","year":"2010"},{"key":"ref13","series-title":"PLoS Negl Trop Dis","first-page":"e1364","article-title":"Post-treatment follow-up study of abdominal cystic echinococcosis in Tibetan communities of northwest Sichuan Province, China","volume":"5","author":"Li","year":"2011"},{"key":"ref14","series-title":"Trop Med Int Health","first-page":"637","article-title":"A correlative study of ultrasound with serology in an area in China co-endemic for human alveolar and cystic echinococcosis","volume":"12","author":"Yang","year":"2007"},{"key":"ref15","series-title":"Clin Vaccine Immunol","first-page":"944","article-title":"Serological diagnosis of lung cystic hydatid disease using the synthetic p176 peptide","volume":"19","author":"Santivanez","year":"2012"},{"key":"ref16","series-title":"Clin Vaccine Immunol","first-page":"147","article-title":"Usefulness of four different Echinococcus granulosus recombinant antigens for serodiagnosis of unilocular hydatid disease (UHD) and postsurgical follow-up of patients treated for UHD","volume":"15","author":"Hernandez-Gonzalez","year":"2008"},{"key":"ref17","series-title":"Trans R Soc Trop Med Hyg","first-page":"126","article-title":"Repeated treatment of cystic echinococcosis in patients with a long-term immunological response after successful surgical cyst removal","volume":"100","author":"Galitza","year":"2006"},{"key":"ref18","series-title":"Clin Exp Immunol","first-page":"485","article-title":"Long-term serological evaluation of patients with cystic echinococcosis treated with benzimidazole carbamates","volume":"129","author":"Rigano","year":"2002"},{"key":"ref19","series-title":"PLoS Negl Trop Dis","first-page":"e3057","article-title":"Long-term sonographic and serological follow-up of inactive echinococcal cysts of the liver: hints for a \u201cwatch-and-wait\u201d approach","volume":"8","author":"Piccoli","year":"2014"}],"container-title":["The American Society of Tropical Medicine and 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