{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:27:53Z","timestamp":1791325673894,"version":"4.3.1"},"reference-count":35,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6,1]]},"abstract":"<jats:p>Sporotrichosis is a polymorphic disease of humans and animals, which is acquired via traumatic inoculation of <jats:italic>Sporothrix<\/jats:italic> propagules into cutaneous or subcutaneous tissue. The etiological agents are in a clinical complex, which includes <jats:italic>Sporothrix brasiliensis<\/jats:italic>, <jats:italic>Sporothrix schenckii<\/jats:italic>, <jats:italic>Sporothrix globosa<\/jats:italic>, and <jats:italic>Sporothrix luriei<\/jats:italic>, each of which has specific epidemiological and virulence characteristics. Classical manifestation in humans includes a fixed localized lesion at the site of trauma plus lymphocutaneous sporotrichosis with fungal spreading along the lymphatic channels. Atypical sporotrichosis is a challenge to diagnosis because it can mimic many other dermatological diseases. We report an unusual, itraconazole-resistant cutaneous lesion of sporotrichosis in a 66-year-old Brazilian man. Histopathological examination of the skin revealed vascular and fibroblastic proliferation with chronic granulomatous infiltrate composed of multinucleated giant cells. <jats:italic>Sporothrix<\/jats:italic> were isolated from the skin lesion, and phylogenetic analyses confirmed it to be sporotrichosis due to <jats:italic>S. globosa<\/jats:italic>, a widespread pathogen. Immunoblotting analysis showed several IgG-reactive molecules in autochthonous preparations of the whole cellular proteins (160, 80, 60, 55, 46, 38, 35, and 30 kDa) and exoantigen (35 and 33 kDa). The patient was first unsuccessfully treated with daily itraconazole, and then successfully treated with potassium iodide.<\/jats:p>","DOI":"10.4269\/ajtmh.15-0267","type":"journal-article","created":{"date-parts":[[2016,4,26]],"date-time":"2016-04-26T02:54:25Z","timestamp":1461639265000},"page":"1218-1222","source":"Crossref","is-referenced-by-count":38,"title":["Atypical Clinical Presentation of Sporotrichosis Caused by Sporothrix globosa Resistant to Itraconazole"],"prefix":"10.4269","volume":"94","author":[{"given":"Olga","family":"Fischman Gompertz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson M.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geisa F.","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri D. L.","family":"Bentubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoilo Pires","family":"de Camargo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ria","family":"Petri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Med Mycol","first-page":"3","article-title":"Global epidemiology of sporotrichosis","volume":"53","author":"Chakrabarti","year":"2015"},{"key":"ref2","series-title":"Persoonia","first-page":"1","article-title":"Phylogeography and evolutionary patterns in Sporothrix spanning more than 14000 human and animal case reports","volume":"35","author":"Zhang","year":"2015"},{"key":"ref3","series-title":"Curr Fungal Infect Rep","first-page":"252","article-title":"Diagnosis and treatment of lymphocutaneous sporotrichosis: what are the options?","volume":"7","author":"Bonifaz","year":"2013"},{"key":"ref4","series-title":"Clin Infect Dis","first-page":"65","article-title":"Sporotrichosis in Peru: description of an area of hyperendemicity","volume":"30","author":"Pappas","year":"2000"},{"key":"ref5","series-title":"J Clin Microbiol","first-page":"3198","article-title":"Sporothrix brasiliensis, S. globosa, and S. mexicana, three new Sporothrix species of clinical interest","volume":"45","author":"Marimon","year":"2007"},{"key":"ref6","series-title":"Med Mycol","first-page":"621","article-title":"Sporothrix luriei: a rare fungus from clinical origin","volume":"46","author":"Marimon","year":"2008"},{"key":"ref7","series-title":"Fungal Divers","first-page":"153","article-title":"Global ITS diversity in the Sporothrix schenckii complex","volume":"66","author":"Zhou","year":"2014"},{"key":"ref8","series-title":"PLoS Negl Trop Dis","first-page":"e2281","article-title":"Phylogenetic analysis reveals a high prevalence of Sporothrix brasiliensis in feline sporotrichosis outbreaks","volume":"7","author":"Rodrigues","year":"2013"},{"key":"ref9","series-title":"Emerg Microbes Infect","first-page":"e32","article-title":"Emerging sporotrichosis is driven by clonal and recombinant Sporothrix species","volume":"3","author":"Rodrigues","year":"2014"},{"key":"ref10","series-title":"Rev Iberoam Micol","first-page":"218","article-title":"Sporothrix globosa, a pathogenic fungus with widespread geographical distribution","volume":"26","author":"Madrid","year":"2009"},{"key":"ref11","series-title":"Mycopathologia","first-page":"67","article-title":"Phenotypic and molecular identification of Sporothrix isolates of clinical origin in northeast China","volume":"176","author":"Yu","year":"2013"},{"key":"ref12","series-title":"BMC Infect Dis","first-page":"94","article-title":"Molecular epidemiology of human sporotrichosis in Venezuela reveals high frequency of Sporothrix globosa","volume":"15","author":"Camacho","year":"2015"},{"key":"ref13","series-title":"Virulence","first-page":"241","article-title":"Characterization of virulence profile, protein secretion and immunogenicity of different Sporothrix schenckii sensu stricto isolates compared with S. globosa and S. brasiliensis species","volume":"4","author":"Fernandes","year":"2013"},{"key":"ref14","series-title":"Clin Microbiol Infect","first-page":"651","article-title":"Different virulence levels of the species of Sporothrix in a murine model","volume":"15","author":"Arrillaga-Moncrieff","year":"2009"},{"key":"ref15","series-title":"BMC Infect Dis","first-page":"219","article-title":"Genetic diversity and antifungal susceptibility profiles in causative agents of sporotrichosis","volume":"14","author":"Rodrigues","year":"2014"},{"key":"ref16","series-title":"Med Mycol","first-page":"178","article-title":"Susceptibility of Sporothrix brasiliensis isolates to amphotericin B, azoles, and terbinafine","volume":"53","author":"Borba-Santos","year":"2015"},{"key":"ref17","series-title":"Med Mycol","first-page":"405","article-title":"Emergence of pathogenicity in the Sporothrix schenckii complex","volume":"51","author":"Rodrigues","year":"2013"},{"key":"ref18","series-title":"Front Microbiol","first-page":"1385","article-title":"Rapid identification of emerging human-pathogenic Sporothrix species with rolling circle amplification","volume":"6","author":"Rodrigues","year":"2015"},{"key":"ref19","series-title":"Mol Biol Evol","first-page":"772","article-title":"MAFFT multiple sequence alignment software version 7: improvements in performance and usability","volume":"30","author":"Katoh","year":"2013"},{"key":"ref20","series-title":"Antimicrob Agents Chemother","first-page":"732","article-title":"In vitro antifungal susceptibilities of five species of Sporothrix","volume":"52","author":"Marimon","year":"2008"},{"key":"ref21","series-title":"J Proteomics","first-page":"8","article-title":"Immunoproteomic analysis reveals a convergent humoral response signature in the Sporothrix schenckii complex","volume":"115","author":"Rodrigues","year":"2015"},{"key":"ref22","series-title":"Med Mycol","first-page":"855","article-title":"Heterogeneity of proteins expressed by Brazilian Sporothrix schenckii isolates","volume":"47","author":"Fernandes","year":"2009"},{"key":"ref23","series-title":"PLoS Negl Trop Dis","first-page":"e0004016","article-title":"Proteomics-based characterization of the humoral immune response in sporotrichosis: toward discovery of potential diagnostic and vaccine antigens","volume":"9","author":"Rodrigues","year":"2015"},{"key":"ref24","series-title":"J Clin Microbiol","first-page":"300","article-title":"Immunoblot analysis of antibody responses to Sporothrix schenckii","volume":"27","author":"Scott","year":"1989"},{"key":"ref25","series-title":"Mycopathologia","first-page":"199","article-title":"Sporothrix schenckii sensu stricto isolated from soil in an armadillo's burrow","volume":"177","author":"Rodrigues","year":"2014"},{"key":"ref26","series-title":"Fungal Biol","first-page":"246","article-title":"Sporothrix chilensis sp. nov. (Ascomycota: Ophiostomatales), a soil-borne agent of human sporotrichosis with mild-pathogenic potential to mammals","volume":"120","author":"Rodrigues","year":"2016"},{"key":"ref27","series-title":"Mycopathologia","first-page":"137","article-title":"Prevalence, epidemiology and geographical distribution of Sporothrix schenckii infections in Gauteng, South Africa","volume":"137","author":"Vismer","year":"1997"},{"key":"ref28","series-title":"Mycopathologia","first-page":"359","article-title":"Sporotrichosis caused by Sporothrix globosa in Rio De Janeiro, Brazil: case report","volume":"169","author":"de Oliveira","year":"2010"},{"key":"ref29","series-title":"J Eur Acad Dermatol Venereol","first-page":"313","article-title":"Report of 457 sporotrichosis cases from Jilin province, northeast China, a serious endemic region","volume":"27","author":"Song","year":"2013"},{"key":"ref30","series-title":"PLoS One","first-page":"e75656","article-title":"Differences in cell morphometry, cell wall topography and Gp70 expression correlate with the virulence of Sporothrix brasiliensis clinical isolates","volume":"8","author":"Castro","year":"2013"},{"key":"ref31","series-title":"J Eur Acad Dermatol Venereol","first-page":"719","article-title":"New posology of potassium iodide for the treatment of cutaneous sporotrichosis: study of efficacy and safety in 102 patients","volume":"29","author":"de Macedo","year":"2015"},{"key":"ref32","series-title":"Curr Fungal Infect Rep","first-page":"220","article-title":"Hyperendemia of sporotrichosis in the Brazilian southeast: learning from clinics and therapeutics","volume":"9","author":"Orofino-Costa","year":"2015"},{"key":"ref33","series-title":"Med Mycol","first-page":"56","article-title":"Antifungal susceptibilities and identification of species of the Sporothrix schenckii complex isolated in Brazil","volume":"52","author":"Ottonelli Stopiglia","year":"2014"},{"key":"ref34","series-title":"J Med Microbiol","first-page":"1607","article-title":"MICs and minimum fungicidal concentrations of amphotericin B, itraconazole, posaconazole and terbinafine in Sporothrix schenckii","volume":"58","author":"Silveira","year":"2009"},{"key":"ref35","series-title":"Br J Dermatol","first-page":"1116","article-title":"Dacryocystitis due to Sporothrix brasiliensis: a case report of a successful clinical and serological outcome with low-dose potassium iodide treatment and oculoplastic surgery","volume":"172","author":"de Macedo","year":"2015"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/94\/6\/article-p1218.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/94\/6\/article-p1218.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/94\/6\/article-p1218.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T22:05:57Z","timestamp":1723068357000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/94\/6\/article-p1218.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,1]]},"references-count":35,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.15-0267","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,1]]}}}