{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:03:35Z","timestamp":1791266615701,"version":"4.1.0"},"reference-count":50,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,2]]},"abstract":"<jats:p>Cystic echinococcosis (CE), a parasitic zoonosis with substantial human health and economic consequences, is highly endemic in Rio Negro Province, Argentina. The objective of this study was to estimate the direct and indirect human and livestock-associated monetary losses attributable to CE, in Rio Negro Province, for the year 2010. Human costs were estimated using data obtained from hospital chart reviews, patient interviews, and government reports. Livestock-associated losses were estimated using data from government reports and scientific publications. Spreadsheet models were developed utilizing Latin Hypercube sampling to account for uncertainty in the input parameters. In 2010, the estimated total cost of CE, in Rio Negro Province, ranged from US$4,234,000 (95% credible interval [CI]: US$2,709,000\u2013US$6,226,000) to US$5,897,000 (95% CI: US$3,452,000\u2013US$9,105,000), with livestock-associated losses representing between 80% and 94% of the total losses, depending on whether non-healthcare-seeking human cases were included and if livestock slaughter values were adjusted to account for underreporting. These estimates suggest that CE is responsible for considerable human and livestock-associated monetary losses in Rio Negro Province. Stakeholders and policymakers can use these data to better allocate public health and agricultural resources for this region.<\/jats:p>","DOI":"10.4269\/ajtmh.15-0304","type":"journal-article","created":{"date-parts":[[2016,1,20]],"date-time":"2016-01-20T04:38:13Z","timestamp":1453264693000},"page":"615-625","source":"Crossref","is-referenced-by-count":17,"title":["The Economic Impact of Cystic Echinococcosis in Rio Negro Province, Argentina"],"prefix":"10.4269","volume":"94","author":[{"given":"Glenda M.","family":"Bingham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmundo","family":"Larrieu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Uchiumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Mercapide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Mujica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Del Carpio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Hererro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan 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concern","volume":"17","author":"Eckert","year":"2004"},{"key":"ref4","series-title":"WHO\/OIE Manual on Echinococcosis in Humans and Animals: a Public Health Problem of Global Concern","year":"2001"},{"key":"ref5","series-title":"Acta Trop","first-page":"113","article-title":"Economic effects of echinococcosis","volume":"85","author":"Torgerson","year":"2003"},{"key":"ref6","series-title":"Adv Parasitol","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0065-308X(05)61011-1","article-title":"Control of cystic echinococcosis\/hydatidosis: 1863\u20132002","volume":"61","author":"Craig","year":"2006"},{"key":"ref7","series-title":"Parasitol Latinoam","first-page":"82","article-title":"Cystic echinococcosis: epidemiology and control in South America","volume":"59","author":"Larrieu","year":"2004"},{"key":"ref8","series-title":"Bol Chil Parasitol","first-page":"49","article-title":"Control program of hydatid disease in the province of Rio Negro Argentina. 1980\u20131997","volume":"55","author":"Larrieu","year":"2000"},{"key":"ref9","series-title":"Lancet Infect Dis","first-page":"385","article-title":"Prevention and control of cystic echinococcosis","volume":"7","author":"Craig","year":"2007"},{"key":"ref10","series-title":"Vet Parasitol","first-page":"281","article-title":"Rate of infection and of reinfection by Echinococcus granulosus in rural dogs of the province of Rio Negro, Argentina","volume":"87","author":"Larrieu","year":"2000"},{"key":"ref11","series-title":"Bol Chil Parasitol","first-page":"8","article-title":"Evaluation of the losses produced by hydatidosis and cost\/benefit analysis of different strategic interventions of control in the Province of Rio Negro, Argentina","volume":"55","author":"Larrieu","year":"2000"},{"key":"ref12","series-title":"Acta Trop","first-page":"81","article-title":"A community-based study to examine the epidemiology of human cystic echinococcosis in Rio Negro Province, Argentina","volume":"136","author":"Bingham","year":"2014"},{"key":"ref13","series-title":"Acta Trop","first-page":"5","article-title":"Ultrasonographic diagnosis and medical treatment of human cystic echinococcosis in asymptomatic school age carriers: 5 years of follow-up","volume":"91","author":"Larrieu","year":"2004"},{"key":"ref14","series-title":"Rev Panam Salud Publica","first-page":"81","article-title":"Critical analysis of cystic echinococcosis control programs and praziquantel use in South America, 1974\u20132010","volume":"31","author":"Larrieu","year":"2012"},{"issue":"Suppl","key":"ref15","series-title":"Parasitol Int","first-page":"S181","article-title":"Cystic echinococcosis in the Americas","volume":"55","author":"Moro","year":"2006"},{"key":"ref16","series-title":"Trends Parasitol","first-page":"327","article-title":"Methods for assessing the burden of parasitic zoonoses: echinococcosis and cysticercosis","volume":"21","author":"Carabin","year":"2005"},{"key":"ref17","series-title":"Bull World Health Organ","first-page":"49","article-title":"Analysis of the economic impact of cystic echinococcosis in Spain","volume":"88","author":"Benner","year":"2010"},{"key":"ref18","series-title":"Am J Trop Med Hyg","first-page":"2","article-title":"Economic effects of echinococcosis in a disease-endemic region of the Tibetan Plateau","volume":"73","author":"Budke","year":"2005"},{"key":"ref19","series-title":"PLoS Negl Trop Dis","first-page":"e1915","article-title":"The monetary burden of cystic echinococcosis in Iran","volume":"6","author":"Harandi","year":"2012"},{"key":"ref20","series-title":"Trans R Soc Trop Med Hyg","first-page":"268","article-title":"Echinococcosis in Tunisia: a cost analysis","volume":"99","author":"Majorowski","year":"2005"},{"key":"ref21","series-title":"PLoS Negl Trop Dis","first-page":"e1179","article-title":"Economic impact of cystic echinococcosis in Peru","volume":"5","author":"Moro","year":"2011"},{"key":"ref22","series-title":"Ann Trop Med Parasitol","first-page":"703","article-title":"Estimating the economic effects of cystic echinococcosis: Uruguay, a developing country with upper-middle income","volume":"94","author":"Torgerson","year":"2000"},{"key":"ref23","series-title":"Ann Trop Med Parasitol","first-page":"177","article-title":"Estimating the economic effects of cystic echinococcosis. Part 2: an endemic region in the United Kingdom, a wealthy, industrialized economy","volume":"95","author":"Torgerson","year":"2001"},{"key":"ref24","series-title":"Censo Nacional de Poblaci\u00f3n, Hogares y Vivienda, 2010","author":"Instituto Nacional de Estad\u00edstica y Censos","year":"2012"},{"key":"ref25","series-title":"Anuario 2010: Ganados Ganader\u00eda y Carnes","author":"Ministerio de Agricultura, Ganader\u00eea y Pesca","year":"2011"},{"key":"ref26","series-title":"Bolet\u00edn Integrado de Vigilancia","author":"Ministerio de Salud","year":"2013"},{"key":"ref27","series-title":"PLoS Negl Trop Dis","first-page":"e1444","article-title":"Early diagnosis, treatment and follow-up of cystic echinococcosis in remote rural areas in Patagonia: impact of ultrasound training of non-specialists","volume":"6","author":"Del Carpio","year":"2012"},{"key":"ref28","series-title":"Am J Trop Med Hyg","first-page":"56","article-title":"Use of disability adjusted life years in the estimation of the disease burden of echinococcosis for a high endemic region of the Tibetan plateau","volume":"71","author":"Budke","year":"2004"},{"key":"ref29","series-title":"Acta Trop","first-page":"1","article-title":"Programme for ultrasound diagnoses and treatment with albendazole of cystic echinococcosis in asymptomatic carriers: 10 years of follow-up of cases","volume":"117","author":"Larrieu","year":"2011"},{"key":"ref30","series-title":"Emerg Infect Dis","first-page":"260","article-title":"Diagnosis of cystic echinococcosis, central Peruvian Highlands","volume":"14","author":"Gavidia","year":"2008"},{"key":"ref31","series-title":"Ann Trop Med Parasitol","first-page":"679","article-title":"Human cystic echinococcosis: contributions to the natural history of the disease","volume":"95","author":"Larrieu","year":"2001"},{"key":"ref32","series-title":"Manual Farmac\u00e9utico","author":"Alfabeta","year":"2011"},{"key":"ref33","series-title":"Official Exchange Rate","author":"World Bank","year":"2011"},{"key":"ref34","series-title":"Encuesta Anual de Hogares Urbanos, 2010","author":"Instituto Nacional de Estad\u00edstica y Censos","year":"2011"},{"key":"ref35","series-title":"Ann Trop Med Parasitol","first-page":"595","article-title":"Estimating the economic effects of cystic echinococcosis. Part 3: Jordan, a developing country with lower-middle income","volume":"95","author":"Torgerson","year":"2001"},{"key":"ref36","series-title":"Transporte P\u00fablico","author":"Ministerio del Interior y Transporte","year":"2013"},{"key":"ref37","series-title":"Pump Price for Gasoline","author":"World Bank","year":"2011"},{"key":"ref38","series-title":"Sistema de vigilancia epidemiologica de la hidatidosis animal, en establecimientos con bovinos, ovinos o porcinos, por medio de la faena en la republica Argentina","author":"Servicio Nacional de Sanidad y Calidad Agroalimentaria","year":"2012"},{"key":"ref39","series-title":"Vet Parasitol","first-page":"263","article-title":"Ovine Echinococcus granulosus transmission dynamics in the province of Rio Negro, Argentina, 1980\u20131999","volume":"98","author":"Larrieu","year":"2001"},{"key":"ref40","series-title":"Emerg Infect Dis","first-page":"296","article-title":"Global socioeconomic impact of cystic echinococcosis","volume":"12","author":"Budke","year":"2006"},{"key":"ref41","series-title":"World Development Indicators 2010","author":"World Bank","year":"2011"},{"key":"ref42","series-title":"Acta Trop","first-page":"143","article-title":"Pilot field trial of the EG95 vaccine against ovine cystic echinococcosis in Rio Negro, Argentina: early impact and preliminary data","volume":"127","author":"Larrieu","year":"2013"},{"key":"ref43","series-title":"Turk J Vet Anim Sci","first-page":"25","article-title":"The effect of different slaughter weights on the fattening performance, slaughter and carcass characteristics of male karayaka lambs","volume":"31","author":"Balci","year":"2007"},{"key":"ref44","series-title":"Egypt J Sheep Goat Sci","first-page":"43","article-title":"Effect of ascorpic acid supplementation on growth performance, carcass traits, physiological parameters and blood constituents of growing lambs","volume":"3","author":"El-Monem","year":"2008"},{"key":"ref45","series-title":"La Producci\u00f3n Ovina en la Argentina","author":"INTA","year":"2012"},{"key":"ref46","series-title":"Meat and Offal Yields of Goats","author":"McGregor","year":"2007"},{"key":"ref47","series-title":"Bolet\u00edn de Difusi\u00f3n Caprina y Ovina 2009","author":"Ministerio de Agricultura, Ganader\u00eda y Pesca","year":"2010"},{"key":"ref48","series-title":"Documento Base de Programa Nacional: Fibras Animales","author":"INTA","year":"2011"},{"key":"ref49","series-title":"Comercializaci\u00f3n de Ganados y Carnes","author":"Iriarte","year":"2009"},{"key":"ref50","series-title":"Fortalecimiento de la Ganader\u00eda Vacuna en la Nueva Zona Libre de Aftosa Patag\u00f3nica","author":"INTA","year":"2013"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/94\/3\/article-p615.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/94\/3\/article-p615.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/94\/3\/article-p615.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T22:11:03Z","timestamp":1723068663000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/94\/3\/article-p615.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,2]]},"references-count":50,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.15-0304","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,2]]}}}