{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:28:57Z","timestamp":1790051337577,"version":"4.0.1"},"reference-count":23,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,11,4]]},"abstract":"<jats:p>We report a case of thrombotic thrombocytopenic purpura (TTP) that immediately followed symptomatic dengue virus infection in a pregnant lady. The patient developed dengue fever at 16 weeks of gestation, resulting in spontaneous abortion. Subsequently, fever reappeared with persistent thrombocytopenia and jaundice. Investigations revealed microangiopathic hemolysis; there was no evidence of disseminated intravascular coagulation. The TTP episode resolved after six cycles of therapeutic plasma exchange with fresh-frozen plasma. An ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 motif 13 repeats) activity assay, done during convalescence, showed normal activity. The patient had an uneventful second pregnancy and has remained free of TTP recurrence for more than 2 years now. We review the pathophysiological basis of TTP in dengue infection, and suggest that jaundice with disproportionate elevation of serum aspartate aminotransferase level in a patient with dengue should arouse the suspicion of TTP.<\/jats:p>","DOI":"10.4269\/ajtmh.15-0326","type":"journal-article","created":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T02:10:23Z","timestamp":1439863823000},"page":"1028-1030","source":"Crossref","is-referenced-by-count":20,"title":["Dengue Virus Infection Triggering Thrombotic Thrombocytopenic Purpura in Pregnancy"],"prefix":"10.4269","volume":"93","author":[{"given":"Surendran","family":"Deepanjali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghuramulu R.","family":"Naik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharada","family":"Mailankody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivamani","family":"Kalaimani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamilarasu","family":"Kadhiravan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Trop Med Int Health","first-page":"1328","article-title":"Clinical and laboratory features that distinguish dengue from other febrile illnesses in endemic populations","volume":"13","author":"Potts","year":"2008"},{"key":"ref2","series-title":"Baillieres Clin Haematol","first-page":"249","article-title":"Mechanisms of dengue virus-induced bone marrow suppression","volume":"8","author":"La 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