{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:12:09Z","timestamp":1791220329363,"version":"4.1.0"},"reference-count":69,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,11,4]]},"abstract":"<jats:p>The genus <jats:italic>Nairovirus<\/jats:italic> of arthropod-borne bunyaviruses includes the important emerging human pathogen, Crimean\u2013Congo hemorrhagic fever virus (CCHFV), as well as Nairobi sheep disease virus and many other poorly described viruses isolated from mammals, birds, and ticks. Here, we report genome sequence analysis of six nairoviruses: Thiafora virus (TFAV) that was isolated from a shrew in Senegal; Yogue (YOGV), Kasokero (KKOV), and Gossas (GOSV) viruses isolated from bats in Senegal and Uganda; Issyk-Kul virus (IKV) isolated from bats in Kyrgyzstan; and Keterah virus (KTRV) isolated from ticks infesting a bat in Malaysia. The S, M, and L genome segments of each virus were found to encode proteins corresponding to the nucleoprotein, polyglycoprotein, and polymerase protein of CCHFV. However, as observed in Leopards Hill virus (LPHV) and Erve virus (ERVV), polyglycoproteins encoded in the M segment lack sequences encoding the double-membrane-spanning CCHFV NSm protein. Amino acid sequence identities, complement-fixation tests, and phylogenetic analysis indicated that these viruses cluster into three groups comprising KKOV, YOGV, and LPHV from bats of the suborder Yingochiroptera; KTRV, IKV, and GOSV from bats of the suborder Yangochiroptera; and TFAV and ERVV from shrews (Soricomorpha: Soricidae). This reflects clade-specific host and vector associations that extend across the genus.<\/jats:p>","DOI":"10.4269\/ajtmh.15-0344","type":"journal-article","created":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T02:18:47Z","timestamp":1441073927000},"page":"1041-1051","source":"Crossref","is-referenced-by-count":41,"title":["Genomic Characterization of Yogue, Kasokero, Issyk-Kul, Keterah, Gossas, and Thiafora Viruses: Nairoviruses Naturally Infecting Bats, Shrews, and Ticks"],"prefix":"10.4269","volume":"93","author":[{"given":"Peter J.","family":"Walker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven G.","family":"Widen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cadhla","family":"Firth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim R.","family":"Blasdell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia P. A.","family":"Travassos da Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilda","family":"Guzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Tesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikos","family":"Vasilakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Curr Opin Virol","first-page":"215","article-title":"Crimean-Congo hemorrhagic fever virus: new outbreaks, new discoveries","volume":"2","author":"Ergonul","year":"2012"},{"key":"ref2","series-title":"Lancet Infect Dis","first-page":"203","article-title":"Crimean-Congo haemorrhagic fever","volume":"6","author":"Ergonul","year":"2006"},{"key":"ref3","series-title":"Antiviral Res","first-page":"159","article-title":"Crimean-Congo hemorrhagic fever: history, epidemiology, pathogenesis, clinical syndrome and genetic diversity","volume":"100","author":"Bente","year":"2013"},{"key":"ref4","series-title":"Parassitologia","first-page":"95","article-title":"Nairobi sheep disease","volume":"39","author":"Davies","year":"1997"},{"key":"ref5","series-title":"Infectious Diseases of Livestock with Special Reference to Southern Africa","first-page":"718","article-title":"Nairobi sheep disease","author":"Terpstra","year":"1994"},{"key":"ref6","series-title":"Virology","first-page":"146","article-title":"Nairobi sheep disease virus, an important tick-borne pathogen of sheep and goats in Africa, is also present in Asia","volume":"303","author":"Marczinke","year":"2002"},{"key":"ref7","series-title":"Emerg Infect Dis","first-page":"718","article-title":"Nairobi sheep disease virus RNA in Ixodid ticks, China, 2013","volume":"21","author":"Gong","year":"2015"},{"key":"ref8","series-title":"Arch Virol","first-page":"1249","article-title":"The molecular biology of nairoviruses, an emerging group of tick-borne arboviruses","volume":"159","author":"Lasecka","year":"2014"},{"key":"ref9","series-title":"Intervirology","first-page":"144","article-title":"The Nairovirus genus: serological relationships","volume":"14","author":"Casals","year":"1980"},{"key":"ref10","series-title":"Virus Taxonomy. 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Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/93\/5\/article-p1041.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/93\/5\/article-p1041.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/93\/5\/article-p1041.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T18:59:43Z","timestamp":1723057183000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/93\/5\/article-p1041.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,4]]},"references-count":69,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.15-0344","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,4]]}}}