{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T13:46:57Z","timestamp":1781704017700,"version":"3.54.5"},"reference-count":26,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,2,3]]},"abstract":"<jats:p><jats:italic>Klebsiella pneumoniae<\/jats:italic> (KP) is the most common cause of neonatal sepsis in the low- and middle-income countries. Our objective was to describe the phenotypic and molecular characteristics of extended-spectrum \u03b2-lactamase (ESBL)-producer KP in neonatal care centers from Peru. We collected 176 non-duplicate consecutive KP isolates from blood isolates of neonates from eight general public hospitals of Lima, Peru. The overall rate of ESBL production was 73.3% (<jats:italic>N<\/jats:italic> = 129). The resistance rates were higher among ESBL-producer isolates when compared with the nonproducers: 85.3% versus 12.8% for gentamicin (<jats:italic>P<\/jats:italic> &lt; 0.01), 59.7% versus 8.5% for trimethoprim\u2013sulfamethoxazole (<jats:italic>P<\/jats:italic> &lt; 0.01), 45.0% versus 8.5% for ciprofloxacin (<jats:italic>P<\/jats:italic> &lt; 0.01), and 36.4% versus 12.8% for amikacin (<jats:italic>P<\/jats:italic> &lt; 0.01). A total of 359 \u03b2-lactamase-encoding genes were detected among 129 ESBL-producer isolates; 109 isolates (84.5%) carried two or more genes. Among 37 ESBL-producer isolates randomly selected, CTX-M-15 and CTX-M-2 were the most common ESBLs detected. Most of the isolates (92%) belonged to the group KpI. Pulsed-field gel electrophoresis showed that multiple KP clones were circulating among the eight neonatal units included.<\/jats:p>","DOI":"10.4269\/ajtmh.15-0373","type":"journal-article","created":{"date-parts":[[2015,12,8]],"date-time":"2015-12-08T14:24:29Z","timestamp":1449584669000},"page":"285-288","source":"Crossref","is-referenced-by-count":17,"title":["Molecular Characterization of Extended-Spectrum \u03b2-Lactamase-Producer Klebsiella pneumoniae Isolates Causing Neonatal Sepsis in Peru"],"prefix":"10.4269","volume":"94","author":[{"given":"Coralith","family":"Garc\u00eda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizeth","family":"Astocondor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Rojo-Bezares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"S\u00e1enz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Infect","first-page":"315","article-title":"Transferable resistance to cefotaxime, cefoxitin, cefamandole and cefuroxime in clinical isolates of Klebsiella pneumoniae and Serratia 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Microbiol","first-page":"466","article-title":"The CTX-M beta-lactamase pandemic","volume":"9","author":"Cant\u00f3n","year":"2006"},{"key":"ref24","series-title":"Antimicrob Agents Chemother","first-page":"6003","article-title":"Changing epidemiology of extended-spectrum \u03b2-lactamases in Argentina: emergence of CTX-M-15","volume":"56","author":"Sennati","year":"2012"},{"key":"ref25","series-title":"Braz J Infect Dis","first-page":"640","article-title":"Molecular epidemiology of CTX-M producer Enterobacteriaceae isolated from bloodstream infections in Rio de Janeiro, Brazil: emergence of CTX-M-15","volume":"17","author":"Seki","year":"2013"},{"key":"ref26","series-title":"Antimicrob Agents Chemother","first-page":"2720","article-title":"Rapid dissemination and diversity of CTX-M extended-spectrum beta-lactamase genes in commensal Escherichia coli isolates from healthy children from low-resource settings in Latin America","volume":"51","author":"Pallecchi","year":"2007"}],"container-title":["The American Society of Tropical Medicine and 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