{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:10:34Z","timestamp":1757700634324},"reference-count":25,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,2,3]]},"abstract":"<jats:p>Anaphylactic shock represents a serious complication of echinococcosis as up to 4.6% of patients die as a result of its severity and improper handling. Once a definite diagnosis is made, effective treatments need to be immediately initiated. Here, we report the immunological characteristics and management of two patients with recurrent anaphylactic shock concurrent with the surgical removal of hydatid cysts. Both patients had systemic echinococcosis classified as cystic echinococcosis type 2 (CE2) with multiple, immature cysts (absence of calcification and necrosis). In addition, both patients had increased eosinophils and basophils before surgery, as well as elevated crude hydatid cyst fluid antigen (anti-EgCF) and hydatid cyst fluid native antigen B (anti-EgB) antibodies and high IgG levels. Although we cannot definitively predict which patients are at risk for cyst fluid leakage or anaphylactic shock at present, clinicians may consider taking precautions before surgery on encountering patients with a similar profile to prevent the occurrence of anaphylactic shock and the likelihood of a second incident. However, these observations need to be confirmed in further studies with a larger number of patients.<\/jats:p>","DOI":"10.4269\/ajtmh.15-0386","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T03:03:18Z","timestamp":1451358198000},"page":"371-377","source":"Crossref","is-referenced-by-count":7,"title":["Immunological Characteristics of Recurrent Echinococcosis-Induced Anaphylactic Shock"],"prefix":"10.4269","volume":"94","author":[{"given":"Jianrong","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Clin Microbiol Rev","first-page":"107","article-title":"Biological, epidemiological, and clinical aspects of echinococcosis, a zoonosis of increasing concern","volume":"17","author":"Eckert","year":"2004"},{"key":"ref2","series-title":"Exp Parasitol","first-page":"439","article-title":"The taxonomy, phylogeny and transmission of Echinococcus","volume":"119","author":"Thompson","year":"2008"},{"key":"ref3","series-title":"Int J Infect Dis","first-page":"125","article-title":"Echinococcosis: a review","volume":"13","author":"Moro","year":"2009"},{"key":"ref4","series-title":"Allergy","first-page":"568","article-title":"Anaphylactic shock by rupture of hydatid hepatic cyst. Follow-up by specific IgE serum antibodies","volume":"47","author":"Saenz de San Pedro","year":"1992"},{"key":"ref5","series-title":"Acta Trop","first-page":"235","article-title":"Epidemiology and control of echinococcosis in central Asia, with particular reference to the People's Republic of China","volume":"141","author":"Zhang","year":"2015"},{"key":"ref6","series-title":"Am J Trop Med Hyg","first-page":"302","article-title":"Spontaneous systemic anaphylaxis as an unusual presentation of hydatid cyst: report of two cases","volume":"55","author":"Mooraki","year":"1996"},{"key":"ref7","series-title":"BMC Med Genet","first-page":"11","article-title":"Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1","volume":"8","author":"Sacco","year":"2007"},{"key":"ref8","series-title":"Clin Exp Immunol","first-page":"124","article-title":"Immunological characterization of Echinococcus granulosus cyclophilin, an allergen reactive with IgE and IgG4 from patients with cystic echinococcosis","volume":"128","author":"Ortona","year":"2002"},{"key":"ref9","series-title":"Recent Pat Antiinfect Drug Discov","first-page":"231","article-title":"Percutaneous treatment of hydatid liver cysts: an update","volume":"7","author":"Giorgio","year":"2012"},{"key":"ref10","series-title":"Front Med China","first-page":"394","article-title":"Diagnosis and management against the complications of human cystic echinococcosis","volume":"4","author":"Wen","year":"2010"},{"key":"ref11","series-title":"Scand J Thorac Cardiovasc Surg","first-page":"175","article-title":"Recurrent anaphylactic shock as a manifestation of echinococcosis. Report of a case","volume":"20","author":"Giulekas","year":"1986"},{"key":"ref12","series-title":"Parasite Immunol","first-page":"45","article-title":"Echinococcus granulosus-specific T-cell lines derived from patients at various clinical stages of cystic echinococcosis","volume":"26","author":"Rigan\u00f2","year":"2004"},{"key":"ref13","series-title":"Am J Trop Med Hyg","first-page":"452","article-title":"Demographic and clinical characteristics of patients with anaphylactic shock after surgery for cystic echinococcosis","volume":"85","author":"Li","year":"2011"},{"key":"ref14","series-title":"Endemic Dis Bull","first-page":"20","article-title":"Experimental observation on relationship between antibody immunity response of hydatid disease and the size or quantity of hydatid cyst","volume":"12","author":"Zhu","year":"1997"},{"key":"ref15","series-title":"Bull World Health Organ","first-page":"741","article-title":"Immunoreactivity in pulmonary echinococcosis. 2. Evaluation of antibody response","volume":"57","author":"Todorov","year":"1979"},{"key":"ref16","series-title":"Vet Parasitol","first-page":"277","article-title":"Mitosis and differentiation in T-cells under cytotoxic action of Echinococcus granulosus hydatid fluid","volume":"96","author":"Macintyre","year":"2001"},{"key":"ref17","series-title":"J Xin Jiang Med Univer","first-page":"22","article-title":"Pathological analysis of human hydatid disease: a report of 37 cases","volume":"26","author":"Zhao","year":"1999"},{"key":"ref18","series-title":"Chin J Parasitol Parasitic Dis","first-page":"358","article-title":"Recognition of specific antigens by specific IgG and IgE during anaphylactic shock induced by Echinococcus granulosus in sheep","volume":"6","author":"Zheng","year":"2002"},{"key":"ref19","series-title":"J Pathog Biol","first-page":"297","article-title":"Advance in the serological diagnosis of echinococcosis","volume":"6","author":"Gulipali","year":"2011"},{"key":"ref20","series-title":"Clin Rev Allergy Immunol","first-page":"93","article-title":"Echinococcosis and allergy","volume":"26","author":"Vuitton","year":"2004"},{"key":"ref21","series-title":"Int J Parasitol","first-page":"279","article-title":"Mass spectrometric analysis of the immunodominant glycan epitope of Echinococcus granulosus antigen Ag5","volume":"42","author":"Paschinger","year":"2012"},{"key":"ref22","series-title":"Chin J Evid Based Med","first-page":"332","article-title":"Diagnostic value of ELISA using antigen B in cystic echinococcosis: a meta-analysis","volume":"13","author":"Li","year":"2013"},{"key":"ref23","series-title":"J Immunol","first-page":"111","article-title":"IL-12 inhibits the production of IL-4 and IL-10 in allergen-specific human CD4+ T lymphocytes","volume":"155","author":"Marshall","year":"1995"},{"key":"ref24","series-title":"Parasite Immunol","first-page":"357","article-title":"Analysis of specific IgE and IgG subclass antibodies for diagnosis of Echinococcus granulosus","volume":"28","author":"Khabiri","year":"2006"},{"key":"ref25","series-title":"Am J Trop Med Hyg","first-page":"104","article-title":"Comparisons of serum total IgE, IgG and IgG1 levels in patients with and without echinococcosis-induced anaphylactic shock","volume":"87","author":"Li","year":"2012"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/94\/2\/article-p371.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/94\/2\/article-p371.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/94\/2\/article-p371.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T22:13:23Z","timestamp":1723068803000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/94\/2\/article-p371.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,3]]},"references-count":25,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.15-0386","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"type":"print","value":"0002-9637"},{"type":"electronic","value":"1476-1645"}],"subject":[],"published":{"date-parts":[[2016,2,3]]}}}