{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:56:50Z","timestamp":1790834210165,"version":"4.1.0"},"reference-count":20,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,6]]},"abstract":"<jats:p>\n                    Artemisinin combination therapy (ACT) is the first line to treat uncomplicated\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    malaria worldwide. Artemisinin treatment failures are on the rise in southeast Asia. Delayed parasite clearance after ACT is associated with mutations of the\n                    <jats:italic>P. falciparum kelch 13<\/jats:italic>\n                    gene. Patients (\n                    <jats:italic>N<\/jats:italic>\n                    = 148) in five districts of northwest Ethiopia were enrolled in a 28-day ACT trial. We identified a unique\n                    <jats:italic>kelch 13<\/jats:italic>\n                    mutation (R622I) in 3\/125 (2.4%) samples. The three isolates with R622I were from Negade-Bahir and Aykel districts close to the Ethiopia\u2013Sudan border. One of three patients with the mutant strain was parasitemic at day 3; however, all patients cleared parasites by day 28. Correlation between\n                    <jats:italic>kelch 13<\/jats:italic>\n                    mutations and parasite clearance was not possible due to the low frequency of mutations in this study.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.15-0477","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T08:33:15Z","timestamp":1445329995000},"page":"132-135","source":"Crossref","is-referenced-by-count":86,"title":["A Unique Plasmodium falciparum K13 Gene Mutation in Northwest Ethiopia"],"prefix":"10.4269","volume":"94","author":[{"given":"Abebe Genetu","family":"Bayih","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gebeyaw","family":"Getnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abebe","family":"Alemu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisay","family":"Getie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abu Naser","family":"Mohon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan R.","family":"Pillai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"World Malaria Report","author":"World Health Organization","year":"2014"},{"key":"ref2","series-title":"Guidelines for the Treatment of Malaria","author":"World Health Organization","year":"2015"},{"key":"ref3","series-title":"N Engl J Med","first-page":"455","article-title":"Artemisinin resistance in Plasmodium falciparum malaria","volume":"361","author":"Dondorp","year":"2009"},{"key":"ref4","series-title":"Nature","first-page":"50","article-title":"A molecular marker of artemisinin-resistant Plasmodium falciparum malaria","volume":"505","author":"Ariey","year":"2014"},{"key":"ref5","series-title":"J Infect Dis","first-page":"670","article-title":"Independent emergence of artemisinin resistance mutations among Plasmodium falciparum in southeast Asia","volume":"211","author":"Takala-Harrison","year":"2015"},{"key":"ref6","series-title":"Science","first-page":"428","article-title":"Drug resistance. 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