{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T07:52:01Z","timestamp":1758268321590},"reference-count":24,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,6]]},"abstract":"<jats:p>Opisthorchiasis is a neglected tropical disease, yet it is of considerable public health importance in Southeast Asia given the predilection for chronically infected persons to develop cholangiocarcinoma. We evaluated a handheld microscope for the diagnosis of <jats:italic>Opisthorchis viverrini<\/jats:italic> in a community-based setting in Lao People's Democratic Republic in comparison with conventional light microscopy. In stool samples collected from 104 individuals, handheld microscopy revealed a sensitivity of 70.6% and a specificity of 89.5% for <jats:italic>O. viverrini<\/jats:italic> infection. Pearson's correlation for quantitative fecal egg counts between the two devices was 0.98 (95% confidence interval: 0.98\u20130.99). With small adjustments to further increase diagnostic sensitivity, a handheld microscope may become a helpful tool to screen for <jats:italic>O. viverrini<\/jats:italic> and other helminth infections in public health settings.<\/jats:p>","DOI":"10.4269\/ajtmh.15-0525","type":"journal-article","created":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T03:14:00Z","timestamp":1446520440000},"page":"158-160","source":"Crossref","is-referenced-by-count":7,"title":["Diagnosis of Opisthorchis viverrini Infection with Handheld Microscopy in Lao People's Democratic Republic"],"prefix":"10.4269","volume":"94","author":[{"given":"Isaac I.","family":"Bogoch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somphou","family":"Sayasone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youthanavanh","family":"Vonghachack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Meister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrg","family":"Utzinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Odermatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason R.","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Keiser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Clin Infect Dis","first-page":"377","article-title":"Laboratory medicine in Africa: a barrier to effective health care","volume":"42","author":"Petti","year":"2006"},{"key":"ref2","series-title":"Lancet","first-page":"507","article-title":"Technologies for global health","volume":"380","author":"Howitt","year":"2012"},{"key":"ref3","series-title":"Lancet Infect Dis","first-page":"546","article-title":"Rapid diagnostic tests for neurological infections in central Africa","volume":"13","author":"Yansouni","year":"2013"},{"key":"ref4","series-title":"Clin Microbiol Infect","first-page":"529","article-title":"New diagnostic tools in 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of multiple stool sampling and use of different diagnostic techniques","volume":"2","author":"Knopp","year":"2008"},{"key":"ref22","series-title":"Acta Trop","first-page":"315","article-title":"Repeated stool sampling and use of multiple techniques enhance the sensitivity of helminth diagnosis: a cross-sectional survey in southern Lao People's Democratic Republic","volume":"141","author":"Sayasone","year":"2015"},{"key":"ref23","series-title":"Acta Trop","first-page":"187","article-title":"Epidemiology of Opisthorchis viverrini","volume":"88","author":"Sithithaworn","year":"2003"},{"key":"ref24","series-title":"Trans R Soc Trop Med Hyg","first-page":"40","article-title":"Epidemiology of Opisthorchis viverrini in a rural district of southern Lao PDR","volume":"101","author":"Sayasone","year":"2007"}],"container-title":["The American Society of Tropical Medicine and 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