{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:05:58Z","timestamp":1790406358737,"version":"4.1.0"},"reference-count":35,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5,4]]},"abstract":"<jats:p>Q fever is an important cause of undifferentiated fever that is rarely recognized or reported in Brazil. The objective of this study was to look for the presence of <jats:italic>Coxiella burnetii<\/jats:italic> during a dengue fever outbreak in the municipality of Itabora\u00ed, Rio de Janeiro, Brazil, where this bacterium had previously infected humans and domesticated animals. Blood samples from clinically suspected dengue fever patients were tested by polymerase chain reaction (PCR) for <jats:italic>C. burnetii<\/jats:italic>; the DNA was detected in nine (3.3%) of 272 patients. One was coinfected with dengue virus, which was also detected in another 166 (61.3%) patients. The nucleotide sequence of PCR amplification and DNA sequencing of the IS<jats:italic>1111<\/jats:italic> transposase elements in the genome of <jats:italic>C. burnetii<\/jats:italic> exhibited 99% identity with the sequence in GenBank. The detection of <jats:italic>C. burnetii<\/jats:italic> in patients suspected of dengue fever indicates that awareness and knowledge of Q fever should be strengthened and that this bacterium is present in Brazil. Finally, because a negative molecular result does not completely rule out the diagnosis of Q fever and the serological assay based on seroconversion was not available, the actual number of this zoonosis is likely to be much higher than that reported in this study.<\/jats:p>","DOI":"10.4269\/ajtmh.15-0575","type":"journal-article","created":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T03:34:11Z","timestamp":1456803251000},"page":"1090-1094","source":"Crossref","is-referenced-by-count":31,"title":["Molecular Identification of Q Fever in Patients with a Suspected Diagnosis of Dengue in Brazil in 2013\u20132014"],"prefix":"10.4269","volume":"94","author":[{"given":"Maria Ang\u00e9lica M. M.","family":"Mares-Guia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Rozental","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandro","family":"Guterres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle dos Santos","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato De Gasperis","family":"Botticini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Kely Carolina","family":"Terra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Marraschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosany","family":"Bochner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elba R. S.","family":"Lemos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Vet Microbiol","first-page":"297","article-title":"Review Q fever","volume":"140","author":"Angelakis","year":"2010"},{"key":"ref2","series-title":"J Clin Microbiol","first-page":"4919","article-title":"Molecular detection of Coxiella burnetii in the sera of patients with Q fever endocarditis or vascular infection","volume":"42","author":"Fenollar","year":"2004"},{"key":"ref3","series-title":"Clin Microbiol Ver","first-page":"518","article-title":"Q fever","volume":"12","author":"Maurin","year":"1999"},{"key":"ref4","series-title":"Euro Surveill","first-page":"20407","article-title":"Q fever in humans and farm animals in four European countries, 1982 to 2010","volume":"18","author":"Georgiev","year":"2013"},{"key":"ref5","series-title":"Am J Trop Med Hyg","first-page":"691","article-title":"Seroprevalence of Q fever in the United States, 2003\u20132004","volume":"81","author":"Anderson","year":"2009"},{"key":"ref6","series-title":"Neth J Med","first-page":"382","article-title":"Q fever in the Netherlands from 2007 to 2010","volume":"68","author":"Delsing","year":"2010"},{"key":"ref7","series-title":"Emerg Infect Dis","first-page":"1320","article-title":"Q fever and the U.S. military [letter]","volume":"11","author":"Anderson","year":"2005"},{"key":"ref8","series-title":"Clin Infect Dis","first-page":"1045","article-title":"In harm's way: infections in deployed American military forces","volume":"43","author":"Aronson","year":"2006"},{"key":"ref9","series-title":"Bioterrorism Agents\/Diseases","author":"Centers for Disease Control and Prevention","year":"2001"},{"key":"ref10","series-title":"Arq Fac Hig Saude Publica Univ Sao Paulo","first-page":"127","article-title":"Investiga\u00e7\u00f5es sobre a febre Q em S\u00e3o Paulo. 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Febre Q","author":"Centro de Informa\u00e7\u00f5es e Respostas Estrat\u00e9gicas de Vigil\u00e2ncia em Sa\u00fade\u2013CIEVS","year":"2015"},{"key":"ref34","series-title":"Emerg Infect Dis","first-page":"563","article-title":"Identification of risk factors for chronic Q fever, the Netherlands","volume":"18","author":"Kampschreur","year":"2012"},{"key":"ref35","series-title":"Clin Infect Dis","first-page":"e8","article-title":"Q fever, spotted fever group, and typhus group rickettsioses among hospitalized febrile patients in northern Tanzania","volume":"53","author":"Prabhu","year":"2011"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/94\/5\/article-p1090.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/94\/5\/article-p1090.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/94\/5\/article-p1090.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T22:07:24Z","timestamp":1723068444000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/94\/5\/article-p1090.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,4]]},"references-count":35,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.15-0575","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,4]]}}}