{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T22:40:06Z","timestamp":1723070406331},"reference-count":9,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,2]]},"abstract":"<jats:p>Treatment of mycobacterial diseases such as tuberculosis (TB) entails long and intense antimicrobial therapy. TB patients are at risk of coinfection with other multidrug-resistant bacteria, such as those from Enterobacteriaceae family, because of antimicrobial selection pressure and nosocomial transmission during prolonged hospital admission. Here, we report on two patients treated for multidrug-resistant TB, who developed severe sepsis due to an extended spectrum \u03b2-lactamase producing organism. Diagnostic culture identified the venous access port as source, and upon surgical removal and antimicrobial therapy rapid clinical improvement was achieved. Increased awareness and knowledge on the prevalence of multi-resistant Enterobacteriaceae is needed, notably in TB centers, to provide a safe hospital environment to our patients.<\/jats:p>","DOI":"10.4269\/ajtmh.15-0690","type":"journal-article","created":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T04:08:25Z","timestamp":1452571705000},"page":"517-518","source":"Crossref","is-referenced-by-count":4,"title":["Multidrug-Resistant Tuberculosis Complicated by Nosocomial Infection with Multidrug-Resistant Enterobacteriaceae"],"prefix":"10.4269","volume":"94","author":[{"given":"Matthias I.","family":"Gr\u00f6schel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Till F.","family":"Omansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wiel","family":"de Lange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tjip S.","family":"van der Werf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari\u00ebtte","family":"Lokate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Bathoorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onno W.","family":"Akkerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ymkje","family":"Stienstra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Gut","first-page":"1591","article-title":"Gut microbiota disturbance during antibiotic therapy: a multi-omic approach","volume":"62","author":"P\u00e9rez-Cobas","year":"2013"},{"key":"ref2","series-title":"BMC Res Notes","first-page":"454","article-title":"Antibiotic consumption and its influence on the resistance in Enterobacteriaceae","volume":"7","author":"Sedl\u00e1kov\u00e1","year":"2014"},{"key":"ref3","series-title":"Infection","first-page":"991","article-title":"Bloodstream infection due to extended-spectrum beta-lactamase (ESBL)-positive K. pneumoniae and E. coli: an analysis of the disease burden in a large cohort","volume":"42","author":"Leistner","year":"2014"},{"key":"ref4","series-title":"PLoS One","first-page":"e4520","article-title":"Clinical deterioration during antitubercular treatment at a district hospital in South Africa: the importance of drug resistance and AIDS defining illnesses","volume":"4","author":"Pepper","year":"2009"},{"key":"ref5","series-title":"J Hosp Infect","first-page":"68","article-title":"Effects of fluoroquinolone restriction (from 2007 to 2012) on resistance in Enterobacteriaceae: interrupted time-series analysis","volume":"91","author":"Sarma","year":"2015"},{"key":"ref6","series-title":"Clin Infect Dis","first-page":"473","article-title":"Epidemiology of ciprofloxacin resistance and its relationship to extended-spectrum beta-lactamase production in Klebsiella pneumoniae isolates causing bacteremia","volume":"30","author":"Paterson","year":"2000"},{"key":"ref7","series-title":"Infect Control Hosp Epidemiol","first-page":"817","article-title":"Recent exposure to antimicrobials and carbapenem-resistant Enterobacteriaceae: the role of antimicrobial stewardship","volume":"33","author":"Marchaim","year":"2012"},{"key":"ref8","series-title":"Clin Microbiol Infect","first-page":"E256","article-title":"Prevalence of extended-spectrum \u03b2-lactamase-producing Enterobacteriaceae in humans living in municipalities with high and low broiler density","volume":"19","author":"Huijbers","year":"2013"},{"key":"ref9","series-title":"Saudi J Biol Sci","first-page":"37","article-title":"Risk factors for acquisition of extended spectrum beta lactamase producing Escherichia coli and Klebsiella 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