{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:58:34Z","timestamp":1789757914889,"version":"4.0.1"},"reference-count":42,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,8,3]]},"abstract":"<jats:p>Infections with helminths and <jats:italic>Plasmodium<\/jats:italic> spp. overlap in their geographical distribution. It has been postulated that helminth infections may influence malarial transmission by altering <jats:italic>Plasmodium falciparum<\/jats:italic> gametocytogenesis. This cross-sectional study assessed the effect of helminth infections on <jats:italic>P. falciparum<\/jats:italic> gametocyte carriage and on humoral immune responses to sexual stage antigens in Gabon. <jats:italic>Schistosoma haematobium<\/jats:italic> and filarial infections as well as <jats:italic>P. falciparum<\/jats:italic> asexual forms and gametocyte carriage were determined. The antibody responses measured were to sexual (Pfs230, Pfs48\/45) and asexual <jats:italic>P. falciparum<\/jats:italic> antigens (AMA1, MSP1, and GLURP). A total of 287 subjects were included. The prevalence of microscopically detectable <jats:italic>P. falciparum<\/jats:italic> asexual parasites was higher in <jats:italic>S. haematobium<\/jats:italic>\u2013infected subjects in comparison to their uninfected counterparts (47% versus 26%, <jats:italic>P<\/jats:italic> = 0.003), but this was not different when filarial infections were considered. <jats:italic>Plasmodium falciparum<\/jats:italic> gametocyte carriage was similar between <jats:italic>Schistosoma<\/jats:italic>- or filaria-infected and uninfected subjects. We observed a significant decrease of Pfs48\/45 immunoglobulin G titer in <jats:italic>S. haematobium<\/jats:italic>\u2013infected subjects (<jats:italic>P<\/jats:italic> = 0.037), whereas no difference was seen for Pfs230 antibody titer, nor for antibodies to AMA1, MSP1, or GLURP. Our findings suggest an effect of <jats:italic>S. haematobium<\/jats:italic> on antibody responses to some <jats:italic>P. falciparum<\/jats:italic> gametocyte antigens that may have consequences for transmission-blocking immunity.<\/jats:p>","DOI":"10.4269\/ajtmh.15-0703","type":"journal-article","created":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T03:04:20Z","timestamp":1465268660000},"page":"394-400","source":"Crossref","is-referenced-by-count":28,"title":["Associations Between Helminth Infections, Plasmodium falciparum Parasite Carriage and Antibody Responses to Sexual and Asexual Stage Malarial Antigens"],"prefix":"10.4269","volume":"95","author":[{"given":"Ulysse","family":"Ateba-Ngoa","sequence":"first","affiliation":[{"name":"1Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands."},{"name":"2Institut f\u00fcr Tropenmedizin, Universit\u00e4t T\u00fcbingen, T\u00fcbingen, Germany."},{"name":"3Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, Lambar\u00e9n\u00e9, Gabon."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Jones","sequence":"additional","affiliation":[{"name":"4Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannot Fr\u00e9jus","family":"Zinsou","sequence":"additional","affiliation":[{"name":"2Institut f\u00fcr Tropenmedizin, Universit\u00e4t T\u00fcbingen, T\u00fcbingen, Germany."},{"name":"3Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, Lambar\u00e9n\u00e9, Gabon."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josiane","family":"Honkpehedji","sequence":"additional","affiliation":[{"name":"2Institut f\u00fcr Tropenmedizin, Universit\u00e4t T\u00fcbingen, T\u00fcbingen, Germany."},{"name":"3Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, Lambar\u00e9n\u00e9, Gabon."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayola Akim","family":"Adegnika","sequence":"additional","affiliation":[{"name":"1Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands."},{"name":"2Institut f\u00fcr Tropenmedizin, Universit\u00e4t T\u00fcbingen, T\u00fcbingen, Germany."},{"name":"3Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, Lambar\u00e9n\u00e9, Gabon."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude Dejon","family":"Agobe","sequence":"additional","affiliation":[{"name":"2Institut f\u00fcr Tropenmedizin, Universit\u00e4t T\u00fcbingen, T\u00fcbingen, Germany."},{"name":"3Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, Lambar\u00e9n\u00e9, Gabon."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marguerite","family":"Massinga-Loembe","sequence":"additional","affiliation":[{"name":"2Institut f\u00fcr Tropenmedizin, Universit\u00e4t T\u00fcbingen, T\u00fcbingen, Germany."},{"name":"3Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, Lambar\u00e9n\u00e9, Gabon."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Mordm\u00fcller","sequence":"additional","affiliation":[{"name":"2Institut f\u00fcr Tropenmedizin, Universit\u00e4t T\u00fcbingen, T\u00fcbingen, Germany."},{"name":"3Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, Lambar\u00e9n\u00e9, Gabon."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teun","family":"Bousema","sequence":"additional","affiliation":[{"name":"4Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom."},{"name":"5Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Yazdanbakhsh","sequence":"additional","affiliation":[{"name":"1Department of Parasitology, 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Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/95\/2\/article-p394.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/95\/2\/article-p394.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/95\/2\/article-p394.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T21:59:26Z","timestamp":1723067966000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/95\/2\/article-p394.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,3]]},"references-count":42,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.15-0703","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,3]]}}}