{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T04:02:13Z","timestamp":1783051333456,"version":"3.54.6"},"reference-count":18,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,7,6]]},"abstract":"<jats:p>We describe a case of human lagochilascariasis, with skull-base involvement and a chronic and relapsing course after treatment. This rare parasitic infection is usually manifested in the head and neck area, characterized by progressive granulomatous inflammation and the formation of abscesses. Transmission to humans most likely occurs by the consumption of undercooked meat of wild rodents. On the basis of literature studies, we propose the most likely life cycle of the parasite that involves wild feline and rodent species, with humans as accidental hosts. Even in endemic areas, it is very difficult to recognize the disease at an early stage. Progression will eventually lead to involvement of the (central) nervous system, as described in our case. Treatment is often difficult and involves resection and prolonged treatment with anthelmintic drugs. Recurrences are not uncommon and at present, long-term oral administration of ivermectin seems to be the most effective treatment.<\/jats:p>","DOI":"10.4269\/ajtmh.15-0792","type":"journal-article","created":{"date-parts":[[2016,5,3]],"date-time":"2016-05-03T02:13:19Z","timestamp":1462241599000},"page":"88-91","source":"Crossref","is-referenced-by-count":4,"title":["A Case of Lagochilascariasis in Suriname with the Involvement of the ENT System and the Skull Base"],"prefix":"10.4269","volume":"95","author":[{"given":"Joeri A. J.","family":"Douma","sequence":"first","affiliation":[{"name":"VU University Medical Center, Amsterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph A. E.","family":"Akrum","sequence":"additional","affiliation":[{"name":"Academic Hospital Paramaribo, Paramaribo, Suriname."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudie Tjong Tjin","family":"Joe","sequence":"additional","affiliation":[{"name":"Academic Hospital Paramaribo, Paramaribo, Suriname."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Chan","sequence":"additional","affiliation":[{"name":"Academic Hospital Paramaribo, Paramaribo, Suriname."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Codrington","sequence":"additional","affiliation":[{"name":"Academic Hospital Paramaribo, Paramaribo, Suriname."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen Gerold S.","family":"Vreden","sequence":"additional","affiliation":[{"name":"Academic Hospital Paramaribo, Paramaribo, Suriname."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Trans R Soc Trop Med Hyg","first-page":"198","article-title":"Infection of the soft tissue of the neck due to Lagochilascaris minor","volume":"87","author":"de Aguilar Nascimento","year":"1993"},{"key":"ref2","series-title":"Vet Parasitol","first-page":"359","article-title":"First report of Lagochilascaris (Nematoda: Ascaridae) eggs in a public park in southern Brazil","volume":"184","author":"de Moura","year":"2012"},{"key":"ref3","series-title":"Trop Geogr Med","first-page":"154","article-title":"The sixth case of Lagochilascaris minor in Suriname","volume":"44","author":"Oostburg","year":"1992"},{"key":"ref4","series-title":"The Handbook of Clinical Neurology\u2013Neuroparasitology and Tropical Neurology","first-page":"265","article-title":"Chapter 21: Other helminthic infections: ascariasis, dracontiasis, lagochilascariasis, micronemiasis","author":"Tanowitz","year":"2013"},{"key":"ref5","series-title":"Rev Soc Bras Med Trop","first-page":"325","article-title":"Lagochilascaris minor: antibody production in experimentally infected mice","volume":"42","author":"Prudente","year":"2009"},{"key":"ref6","series-title":"Mem Inst Oswaldo Cruz","first-page":"525","article-title":"Experimental heteroxenous cycle of Lagochilascaris minor Leiper, 1909 (Nematoda: Ascarididae) in white mice and in cats","volume":"87","author":"Volcan","year":"1992"},{"key":"ref7","series-title":"J Parasitol Res","first-page":"610457","article-title":"Lagochilascaris minor: susceptibility and resistance to experimental infection in mice is independent of H-2a haplotype and correlates with the immune response in immunized animals","volume":"2010","author":"Spadafora-Ferreira","year":"2010"},{"key":"ref8","series-title":"Mem Inst Oswaldo Cruz","first-page":"441","article-title":"Wild rodents as experimental intermediate hosts of Lagochilascaris minor Leiper, 1909","volume":"94","author":"Pa\u00e7\u00f4","year":"1999"},{"key":"ref9","series-title":"Rev Inst Med Trop Sao Paulo","first-page":"373","article-title":"Human lagochilascariasis treated successfully with ivermectin: a case report","volume":"35","author":"Bento","year":"1993"},{"key":"ref10","series-title":"Vet Parasitol","first-page":"541","article-title":"Case report: feline infection by Lagochilascaris sp. in the state of Rio Grande do Sul, Brazil","volume":"196","author":"Faccio","year":"2013"},{"key":"ref11","series-title":"Microbes Infect","first-page":"2725","article-title":"Lagochilascaris minor third-stage larvae secrete metalloproteases with specificity for fibrinogen and native collagen","volume":"8","author":"Barbosa","year":"2006"},{"key":"ref12","series-title":"Mem Inst Oswaldo Cruz","first-page":"393","article-title":"Experimental lagochilascariosis: histopathological study of inflammatory response to larval migration in the murine model","volume":"99","author":"Semerene","year":"2004"},{"key":"ref13","series-title":"Rev Inst Med Trop Sao Paulo","first-page":"355","article-title":"Lagochilascariasis leading to severe involvement of ocular globes, ears and meninges","volume":"50","author":"Aquino","year":"2008"},{"key":"ref14","series-title":"Rev Inst Med Trop Sao Paulo","first-page":"587","article-title":"Lagoquilascariase humana. Sobre tres casos encontrados no distrito federal, Brazil","volume":"34","author":"Veloso","year":"1992"},{"key":"ref15","series-title":"Int J Dermatol","first-page":"56","article-title":"Infestation from Lagochilascaris minor in Mexico","volume":"36","author":"Vargas-Ocampo","year":"1997"},{"key":"ref16","series-title":"Rev Soc Bras Med Trop","first-page":"373","article-title":"Assessment of ivermectin therapeutic efficacy on fourth stage larvae of Lagochilascariasis minor in experimentally infected cats","volume":"34","author":"Barbosa","year":"2001"},{"key":"ref17","series-title":"Am J Trop Med Hyg","first-page":"548","article-title":"Lagochilascaris minor infection in Suriname. Report of a case","volume":"17","author":"Oostburg","year":"1968"},{"key":"ref18","series-title":"Am J Trop Med Hyg","first-page":"580","article-title":"Thiabendazole therapy of Lagochilascaris minor infection in Suriname. 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