{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T01:10:00Z","timestamp":1792285800603,"version":"4.4.0"},"reference-count":14,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,10,5]]},"abstract":"<jats:p>It is challenging to find safe, nonscarring and noninvasive treatment of facial cutaneous leishmaniasis (CL) in children. Herein, we report a child with CL from a region endemic for <jats:italic>Leishmania tropica<\/jats:italic>, whose lesion persisted after treatment with oral fluconazole but responded to topical paromomycin. Paromomycin should be considered early for treatment of Old World CL and is a well-tolerated and effective mode of therapy for facial lesions.<\/jats:p>","DOI":"10.4269\/ajtmh.15-0860","type":"journal-article","created":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T01:38:41Z","timestamp":1471916321000},"page":"793-794","source":"Crossref","is-referenced-by-count":11,"title":["Successful Treatment of Cutaneous Leishmaniasis with Topical Paramomycin in a Child After Treatment Failure with Systemic Fluconazole"],"prefix":"10.4269","volume":"95","author":[{"given":"Anila","family":"Chacko","sequence":"first","affiliation":[{"name":"1Division of Infectious Diseases, Hospital for Sick Children, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa","family":"Joseph","sequence":"additional","affiliation":[{"name":"2Department of Pediatrics, University of Toronto, Toronto, Canada."},{"name":"4Division of Dermatology, Women's College Hospital, University of Toronto, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Feltis","sequence":"additional","affiliation":[{"name":"5Lifelabs Medical Laboratory Services, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun K.","family":"Morris","sequence":"additional","affiliation":[{"name":"1Division of Infectious Diseases, Hospital for Sick Children, Toronto, Canada."},{"name":"2Department of Pediatrics, University of Toronto, Toronto, Canada."},{"name":"3Centre for Global Child Health, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children Research Institute, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Leishmaniasis: Situation and Trends and Leishmaniasis Resources","author":"World Health Organization","year":"2015"},{"key":"ref2","series-title":"Lancet Infect Dis","first-page":"581","article-title":"Cutaneous leishmaniasis","volume":"7","author":"Reithinger","year":"2007"},{"key":"ref3","series-title":"Pediatr Infect Dis J","first-page":"357","article-title":"Management of Old World cutaneous leishmaniasis in refugee children","volume":"29","author":"Crogan","year":"2010"},{"key":"ref4","series-title":"Postgrad Med J","first-page":"649","article-title":"Leishmaniasis","volume":"82","author":"Piscopo","year":"2006"},{"key":"ref5","series-title":"Australas J Dermatol","first-page":"195","article-title":"Cutaneous leishmaniasis in a child treated with oral fluconazole","volume":"51","author":"Sklavos","year":"2010"},{"key":"ref6","series-title":"Pediatr Infect Dis J","first-page":"1083","article-title":"Oral fluconazole treatment for extensive cutaneous leishmaniasis in an 11-year-old child","volume":"25","author":"Toubiana","year":"2006"},{"key":"ref7","series-title":"Clin Exp Dermatol","first-page":"546","article-title":"Cutaneous leishmaniasis in a Kosovan child treated with oral fluconazole","volume":"29","author":"Baron","year":"2004"},{"key":"ref8","series-title":"Pediatr Dermatol","first-page":"154","article-title":"Cutaneous leishmaniasis: treatment with low-dose oral fluconazole with an excellent cosmetic result","volume":"32","author":"Aerts","year":"2015"},{"key":"ref9","series-title":"N Engl J Med","first-page":"891","article-title":"Fluconazole for the treatment of cutaneous leishmaniasis caused by Leishmania major","volume":"346","author":"Alrajhi","year":"2002"},{"key":"ref10","series-title":"J Am Acad Dermatol","first-page":"606","article-title":"Superior efficacy of oral fluconazole 400 mg daily versus oral fluconazole 200 mg daily in the treatment of cutaneous Leishmania major infection: a randomized clinical trial","volume":"64","author":"Emad","year":"2011"},{"key":"ref11","series-title":"J Am Acad Dermatol","first-page":"271","article-title":"Leishmania tropica in children: a retrospective study","volume":"71","author":"Solomon","year":"2014"},{"key":"ref12","series-title":"N Engl J Med","first-page":"524","article-title":"Topical paromomycin with or without gentamicin for cutaneous leishmaniasis","volume":"368","author":"Ben Salah","year":"2013"},{"key":"ref13","series-title":"J Antimicrob Chemother","first-page":"577","article-title":"The sensitivity of Leishmania species to aminosidine","volume":"35","author":"Neal","year":"1995"},{"key":"ref14","series-title":"PLoS Negl Trop Dis","first-page":"e381","article-title":"Is paromomycin an effective and safe treatment against cutaneous leishmaniasis? A meta-analysis of 14 randomized controlled trials","volume":"3","author":"Kim","year":"2009"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/95\/4\/article-p793.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/95\/4\/article-p793.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/95\/4\/article-p793.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T21:56:07Z","timestamp":1723067767000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/95\/4\/article-p793.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,5]]},"references-count":14,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.15-0860","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,5]]}}}