{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:25:41Z","timestamp":1754396741816},"reference-count":10,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,8,3]]},"abstract":"<jats:p>Herein, we report a case of fatal melioidosis in a newborn. The newborn died of serious melioidosis with respiratory and multiorgan failure at 16 days of age despite extensive treatment with antibiotics and methylprednisolone. <jats:italic>Burkholderia pseudomallei<\/jats:italic> was isolated from the infant's blood and cerebrospinal fluid and identified as a novel sequence type (ST-1341). His father had cough and fever when the newborn was born, and a localized patchy infiltration on the right upper lung was seen in chest radiography, but <jats:italic>B. pseudomallei<\/jats:italic> was not isolated. Two years later, the father developed cough and fever again, and the same novel sequence type of <jats:italic>B. pseudomallei<\/jats:italic> was isolated from the blood of the father. It is postulated that transmission of <jats:italic>B. pseudomallei<\/jats:italic> from the father to the newborn might have occurred during close contact in the first couple of days after birth. Given the high mortality of neonatal melioidosis, particular attention must be paid when the caretakers of the newborn develop fever of unknown origin in a melioidosis-endemic region.<\/jats:p>","DOI":"10.4269\/ajtmh.15-0899","type":"journal-article","created":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T03:05:26Z","timestamp":1462849526000},"page":"444-446","source":"Crossref","is-referenced-by-count":8,"title":["Fatal Melioidosis in a Newborn from Hainan, China"],"prefix":"10.4269","volume":"95","author":[{"given":"Yao","family":"Fang","sequence":"first","affiliation":[{"name":"1Department of Clinical Microbiology and Immunology of Southwest Hospital, College of Medical Laboratory Science, Third Military Medical University, Chongqing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Chen","sequence":"additional","affiliation":[{"name":"2Department of Clinical Laboratory, People's Hospital of Sanya City, Hainan Province, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiong","family":"Zhu","sequence":"additional","affiliation":[{"name":"1Department of Clinical Microbiology and Immunology of Southwest Hospital, College of Medical Laboratory Science, Third Military Medical University, Chongqing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuhu","family":"Mao","sequence":"additional","affiliation":[{"name":"2Department of Clinical Laboratory, People's Hospital of Sanya City, Hainan Province, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"PLoS Negl Trop Dis","first-page":"e2105","article-title":"Systematic review and consensus guidelines for environmental sampling of Burkholderia pseudomallei","volume":"7","author":"Limmathurotsakul","year":"2013"},{"key":"ref2","series-title":"Biomaterials","first-page":"6086","article-title":"Immune responses to vaccines involving a combined antigen-nanoparticle mixture and nanoparticle-encapsulated antigen formulation","volume":"35","author":"Zhang","year":"2014"},{"key":"ref3","series-title":"Trans R Soc Trop Med Hyg","first-page":"636","article-title":"Melioidosis in Hainan, China: a retrospective study","volume":"109","author":"Fang","year":"2015"},{"key":"ref4","series-title":"Acta Trop","first-page":"157","article-title":"Melioidosis research in China","volume":"77","author":"Yang","year":"2000"},{"key":"ref5","series-title":"N Engl J Med","first-page":"1171","article-title":"Mother-to-child transmission of Burkholderia pseudomallei","volume":"344","author":"Abbink","year":"2001"},{"key":"ref6","series-title":"J Microbiol Methods","first-page":"297","article-title":"Validation of ten new polymorphic tandem repeat loci and application to the MLVA typing of Burkholderia pseudomallei isolates collected in Singapore from 1988 to 2004","volume":"77","author":"Michelle Wong Su","year":"2009"},{"key":"ref7","series-title":"Pediatr Infect Dis J","first-page":"634","article-title":"Neonatal melioidosis: a report of 5 cases","volume":"7","author":"Lumbiganon","year":"1988"},{"key":"ref8","series-title":"Pediatr Infect Dis J","first-page":"136","article-title":"Clinical manifestations of melioidosis in children","volume":"14","author":"Lumbiganon","year":"1995"},{"key":"ref9","series-title":"Southeast Asian J Trop Med Public Health","first-page":"856","article-title":"Neurological manifestations of melioidosis in children","volume":"29","author":"Saipan","year":"1998"},{"key":"ref10","series-title":"Int J Dermatol","first-page":"929","article-title":"Melioidosis in children: a retrospective study","volume":"54","author":"Foong","year":"2015"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/95\/2\/article-p444.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/95\/2\/article-p444.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/95\/2\/article-p444.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T21:58:51Z","timestamp":1723067931000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/95\/2\/article-p444.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,3]]},"references-count":10,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.15-0899","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"type":"print","value":"0002-9637"},{"type":"electronic","value":"1476-1645"}],"subject":[],"published":{"date-parts":[[2016,8,3]]}}}