{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:50:00Z","timestamp":1791294600609,"version":"4.1.0"},"reference-count":16,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,3]]},"abstract":"<jats:p>From September 2013 to July 2014, several gold miners working in the tropical forest consulted the Maripasoula Health Center in French Guiana for edema and findings consistent with right-sided cardiac failure. Of the 42 cases of beriberi that were diagnosed, one patient died. The laboratory and clinical investigation demonstrated vitamin B1 deficiency in most of the patients tested. Furthermore, 30 of 42 patients responded favorably to 500 mg of intravenous or intramuscular thiamine supplementation. In addition, dietary investigation showed insufficient thiamine intake in these patients. We concluded that patients had acquired beriberi because of diet restrictions, hard labor, and infectious diseases, notably malaria. In 2016, cases were still being reported. We recommend screening for compatible symptoms in gold miners, thiamine supplementation, and nutritional intervention.<\/jats:p>","DOI":"10.4269\/ajtmh.15-0906","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T17:26:33Z","timestamp":1489512393000},"page":"1248-1252","source":"Crossref","is-referenced-by-count":20,"title":["A Large Outbreak of Thiamine Deficiency Among Illegal Gold Miners in French Guiana"],"prefix":"10.4269","volume":"96","author":[{"given":"Emilie","family":"Mosnier","sequence":"first","affiliation":[{"name":"P\u00f4le des Centres D\u00e9localis\u00e9s de Pr\u00e9vention et de Soins, Centre Hospitalier Andr\u00e9e Rosemon, Cayenne, French Guiana, France."},{"name":"Equipe EA3593, Ecosyst\u00e8mes Amazoniens et Pathologie Tropicale, Universit\u00e9 des Antilles et de la Guyane, Cayenne, French Guiana, France."},{"name":"Unit\u00e9 de Maladies Infectieuses et Tropicales, Centre Hospitalier Andr\u00e9e Rosemon, Cayenne, French Guiana, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Niemetzky","sequence":"additional","affiliation":[{"name":"P\u00f4le des Centres D\u00e9localis\u00e9s de Pr\u00e9vention et de Soins, Centre Hospitalier Andr\u00e9e Rosemon, Cayenne, French Guiana, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Stroot","sequence":"additional","affiliation":[{"name":"P\u00f4le des Centres D\u00e9localis\u00e9s de Pr\u00e9vention et de Soins, Centre Hospitalier Andr\u00e9e Rosemon, Cayenne, French Guiana, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent Pommier","family":"de Santi","sequence":"additional","affiliation":[{"name":"Direction Inter-arm\u00e9es du Service de Sant\u00e9 en Guyane, Base de D\u00e9fense de Guyane, Cayenne, French Guiana, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Brousse","sequence":"additional","affiliation":[{"name":"P\u00f4le des Centres D\u00e9localis\u00e9s de Pr\u00e9vention et de Soins, Centre Hospitalier Andr\u00e9e Rosemon, Cayenne, French Guiana, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basma","family":"Guarmit","sequence":"additional","affiliation":[{"name":"P\u00f4le des Centres D\u00e9localis\u00e9s de Pr\u00e9vention et de Soins, Centre Hospitalier Andr\u00e9e Rosemon, Cayenne, French Guiana, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Blanchet","sequence":"additional","affiliation":[{"name":"Laboratoire Hospitalo Universitaire de Parasitologie et Mycologie, Centre Hospitalier Andr\u00e9e Rosemon, Cayenne, French Guiana, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Ville","sequence":"additional","affiliation":[{"name":"P\u00f4le des Centres D\u00e9localis\u00e9s de Pr\u00e9vention et de Soins, Centre Hospitalier Andr\u00e9e Rosemon, Cayenne, French Guiana, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Abboud","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Maladies Infectieuses et Tropicales, Centre Hospitalier Andr\u00e9e Rosemon, Cayenne, French Guiana, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Djossou","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Maladies Infectieuses et Tropicales, Centre Hospitalier Andr\u00e9e Rosemon, Cayenne, French Guiana, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Nacher","sequence":"additional","affiliation":[{"name":"Equipe EA3593, Ecosyst\u00e8mes Amazoniens et Pathologie Tropicale, Universit\u00e9 des Antilles et de la Guyane, Cayenne, French Guiana, France."},{"name":"Centre d'Investigation Clinique Epid\u00e9miologie Clinique Antilles Guyane, Cayenne, French Guiana, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Estimation de l'emprise de l'activit\u00e9 Aurif\u00e8re Ill\u00e9gale en Guyane\u2013Ann\u00e9e 2008","author":"World Wildlife Fund","year":"2013"},{"key":"ref2","series-title":"Environ Health Perspect","first-page":"449","article-title":"Gold-mining activities and mercury contamination of native Amerindian communities in French Guiana: key role of fish in dietary uptake","volume":"109","author":"Fr\u00e9ry","year":"2001"},{"key":"ref3","series-title":"Malar J","first-page":"152","article-title":"Made in Europe: will artemisinin resistance emerge in French Guiana?","volume":"12","author":"Nacher","year":"2013"},{"key":"ref4","series-title":"Mem Inst Oswaldo Cruz","first-page":"525","article-title":"Malaria on the Guiana Shield: a review of the situation in French Guiana","volume":"109","author":"Musset","year":"2014"},{"key":"ref5","series-title":"Bull Epidemiol Hebd (Paris)","first-page":"181","article-title":"Multiple outbreaks in gold washing camps in the Amazon forest (French Guiana): what are lessons learned to improve access to prevention and care?","volume":"11","author":"Mosnier","year":"2015"},{"key":"ref6","series-title":"Trans R Soc Trop Med Hyg","first-page":"251","article-title":"Beri-beri: the major cause of infant mortality in Karen refugees","volume":"97","author":"Luxemburger","year":"2003"},{"key":"ref7","series-title":"Thiamine Deficiency and Its Prevention and Control in Major Emergencies","author":"World Health Organization, United Nations High Commissioner for Refugees","year":"1999"},{"key":"ref8","series-title":"PLoS Negl Trop Dis","first-page":"e0003581","article-title":"Beriberi (thiamine deficiency) and high infant mortality in northern Laos","volume":"9","author":"Barennes","year":"2015"},{"key":"ref9","series-title":"Am J Trop Med Hyg","first-page":"1093","article-title":"Outbreak of beriberi in an Indian population of the upper Amazon region, Roraima State, Brazil, 2008","volume":"83","author":"Cerroni","year":"2010"},{"key":"ref10","series-title":"Acta Trop","first-page":"193","article-title":"Beriberi in a well-nourished Amazonian population","volume":"70","author":"San Sebastian","year":"1998"},{"key":"ref11","series-title":"Bull Soc Pathol Exot","first-page":"603","article-title":"Ankylostomiase et B\u00e9rib\u00e9ri en Guyane fran\u00e7aise","volume":"13","author":"Dufouger\u00e9","year":"1920"},{"key":"ref12","series-title":"Journal des Voyages et des Aventures de Terre et de mer","first-page":"22","volume":"2","author":"Coudreau","year":"1895"},{"key":"ref13","series-title":"Food Addit Contam Part A Chem Anal Control Expo Risk Assess","first-page":"584","article-title":"Purification and full characterisation of citreoviridin produced by Penicillium citreonigrum in yeast extract sucrose (YES) medium","volume":"32","author":"Da Rocha","year":"2015"},{"key":"ref14","series-title":"Trop Med Int Health","first-page":"363","article-title":"Thiamin deficiency and uncomplicated falciparum malaria in Laos","volume":"12","author":"Mayxay","year":"2007"},{"key":"ref15","series-title":"Southeast Asian J Trop Med Public Health","first-page":"130","article-title":"Beriberi outbreak among commercial fishermen, Thailand 2005","volume":"38","author":"Doung-ngern","year":"2007"},{"key":"ref16","series-title":"Nutrients","first-page":"135","article-title":"A retrospective investigation of thiamin and energy intakes following an outbreak of beriberi in The 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