{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T00:00:43Z","timestamp":1794009643464,"version":"4.8.0"},"reference-count":21,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6,1]]},"abstract":"<jats:p>The Alere Filariasis Test Strip (FTS) is a qualitative, point-of-care diagnostic tool that detects <jats:italic>Wuchereria bancrofti<\/jats:italic> circulating filarial antigen (CFA) in human blood, serum, or plasma. The Global Program to Eliminate Lymphatic Filariasis employs the FTS for mapping filariasis-endemic areas and assessing the success of elimination efforts. The objective of this study was to explore the relationship between the intensity of positive test lines obtained by FTS with CFA levels as determined by enzyme-linked immunosorbent assay (ELISA) with blood and plasma samples from 188 individuals who live in a filariasis-endemic area. The intensity of the FTS test line was assessed visually to provide a semiquantitative score (visual Filariasis Test Strip [vFTS]), and line intensity was measured with a portable spectrodensitometer (quantitative Filariasis Test Strip [qFTS]). These results were compared with antigen levels measured by ELISA in plasma from the same subjects. qFTS measurements were highly correlated with vFTS scores (\u03c1 = 0.94; <jats:italic>P<\/jats:italic> &lt; 0.001) and with plasma CFA levels (\u03c1 = 0.91; <jats:italic>P<\/jats:italic> &lt; 0.001). Thus, qFTS assessment is a convenient method for quantifying <jats:italic>W. bancrofti<\/jats:italic> CFA levels in human blood, which are correlated with adult worm burdens. This tool may be useful for assessing the impact of treatment on adult filarial worms in individuals and communities.<\/jats:p>","DOI":"10.4269\/ajtmh.15-0916","type":"journal-article","created":{"date-parts":[[2016,4,26]],"date-time":"2016-04-26T02:54:25Z","timestamp":1461639265000},"page":"1324-1329","source":"Crossref","is-referenced-by-count":38,"title":["Measurement of Circulating Filarial Antigen Levels in Human Blood with a Point-of-Care Test Strip and a Portable Spectrodensitometer"],"prefix":"10.4269","volume":"94","author":[{"given":"C\u00e9dric B.","family":"Chesnais","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnny","family":"Vlaminck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Billy","family":"Kunyu-Shako","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien D.","family":"Pion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi-Pitchouna","family":"Awaca-Uvon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary J.","family":"Weil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieudonn\u00e9","family":"Mumba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Boussinesq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Wkly Epidemiol Rec","first-page":"389","article-title":"Global programme to eliminate lymphatic filariasis: progress report for 2012","volume":"37","author":"World Health Organization","year":"2013"},{"key":"ref2","series-title":"Trends 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onchocerciasis and its applications in the epidemiological evaluation of the Onchocerciasis Control Programme in the Volta River basin area","volume":"64","author":"Remme","year":"1986"},{"key":"ref20","series-title":"Lancet","first-page":"992","article-title":"Effect of yearly mass drug administration with diethylcarbamazine and albendazole on bancroftian filariasis in Egypt: a comprehensive assessment","volume":"367","author":"Ramzy","year":"2006"},{"key":"ref21","series-title":"Anal Bioanal Chem","first-page":"3263","article-title":"Cellphone-based devices for bioanalytical sciences","volume":"406","author":"Vashist","year":"2013"}],"container-title":["The American Society of Tropical Medicine and 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