{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T01:27:48Z","timestamp":1793755668534,"version":"4.6.1"},"reference-count":38,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,12]]},"abstract":"<jats:p>\n                    Histoplasmosis is one of the most common and deadly opportunistic infections among persons living with human immunodeficiency virus (HIV)\/acquired immune deficiency syndrome in Latin America, but due to limited diagnostic capacity in this region, few data on the burden and clinical characteristics of this disease exist. Between 2005 and 2009, we enrolled patients \u2265 18 years of age with suspected histoplasmosis at a hospital-based HIV clinic in Guatemala City. A case of suspected histoplasmosis was defined as a person presenting with at least three of five clinical or radiologic criteria. A confirmed case of histoplasmosis was defined as a person with a positive culture or urine antigen test for\n                    <jats:italic>Histoplasma capsulatum<\/jats:italic>\n                    . Demographic and clinical data were also collected and analyzed. Of 263 enrolled as suspected cases of histoplasmosis, 101 (38.4%) were confirmed cases. Median time to diagnosis was 15 days after presentation (interquartile range [IQR] = 5\u201323). Crude overall mortality was 43.6%; median survival time was 19 days (IQR = 4\u201369). Mycobacterial infection was diagnosed in 70 (26.6%) cases; 26 (25.7%) histoplasmosis cases were coinfected with mycobacteria. High mortality and short survival time after initial symptoms were observed in patients with histoplasmosis. Mycobacterial coinfection diagnoses were frequent, highlighting the importance of pursuing diagnoses for both diseases.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.16-0009","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T03:00:49Z","timestamp":1496718049000},"page":"42-48","source":"Crossref","is-referenced-by-count":66,"title":["High Mortality and Coinfection in a Prospective Cohort of Human Immunodeficiency Virus\/Acquired Immune Deficiency Syndrome Patients with Histoplasmosis in Guatemala"],"prefix":"10.4269","volume":"97","author":[{"given":"Blanca","family":"Samayoa","sequence":"first","affiliation":[{"name":"Clinica Familiar \u201cLuis \u00c1ngel Garc\u00eda,\u201d Hospital General San Juan de Dios\/Asociaci\u00f3n de Salud Integral, Guatemala, Guatemala;"},{"name":"Facultad de Ciencias Qu\u00edmicas y Farmacia, Universidad de San Carlos de Guatemala, Guatemala, Guatemala;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Roy","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Ahlquist","family":"Cleveland","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narda","family":"Medina","sequence":"additional","affiliation":[{"name":"Clinica Familiar \u201cLuis \u00c1ngel Garc\u00eda,\u201d Hospital General San Juan de Dios\/Asociaci\u00f3n de Salud Integral, Guatemala, Guatemala;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia","family":"Lau-Bonilla","sequence":"additional","affiliation":[{"name":"Clinica Familiar \u201cLuis \u00c1ngel Garc\u00eda,\u201d Hospital General San Juan de Dios\/Asociaci\u00f3n de Salud Integral, Guatemala, Guatemala;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M.","family":"Scheel","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz L.","family":"Gomez","sequence":"additional","affiliation":[{"name":"School of Medicine, Universidad del Rosario, Bogota, Colombia;"},{"name":"Corporaci\u00f3n para Investigaciones Biol\u00f3gicas, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Chiller","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Arathoon","sequence":"additional","affiliation":[{"name":"Clinica Familiar \u201cLuis \u00c1ngel Garc\u00eda,\u201d Hospital General San Juan de Dios\/Asociaci\u00f3n de Salud Integral, Guatemala, Guatemala;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Med Mycol","first-page":"785","article-title":"Epidemiology of endemic systemic fungal infections in Latin America","volume":"49","author":"Colombo","year":"2011"},{"issue":"(Suppl 1)","key":"ref2","series-title":"Med Mycol","first-page":"269","article-title":"Mycoses associated with AIDS in the Third World","volume":"38","author":"Marques","year":"2000"},{"key":"ref3","series-title":"Curr Opin Infect Dis","first-page":"443","article-title":"American histoplasmosis in developing countries with a special focus on patients with HIV: diagnosis, treatment, and prognosis","volume":"19","author":"Couppie","year":"2006"},{"key":"ref4","series-title":"Curr Fungal Infect Rep","first-page":"199","article-title":"Histoplasmosis: epidemiology in Latin America","volume":"5","author":"G\u00f3mez","year":"2011"},{"key":"ref5","series-title":"Int J Med 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2000 to 2009","volume":"13","author":"Myint","year":"2014"},{"key":"ref38","series-title":"J Int Assoc Physicians AIDS Care (Chic)","first-page":"296","article-title":"HIV-associated histoplasmosis in a nonendemic area of the United States during the HAART era: role of migration from endemic areas and lack of antiretroviral therapy","volume":"9","author":"Anderson","year":"2010"}],"container-title":["The American Society of Tropical Medicine and 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