{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:06:25Z","timestamp":1789880785214,"version":"4.0.1"},"reference-count":38,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,8,3]]},"abstract":"<jats:p><jats:italic>Bartonella<\/jats:italic> infections are widespread and highly prevalent in rodents. Several rodent-associated <jats:italic>Bartonella<\/jats:italic> species have been related to human diseases. Recently, <jats:italic>Bartonella<\/jats:italic> species was reported as the etiology of a human case in the country of Georgia (Caucasus). However, information on <jats:italic>Bartonella<\/jats:italic> in rodents in Georgia is absent. Rodent hearts were collected from Georgia to investigate the presence and diversity of <jats:italic>Bartonella<\/jats:italic> species. <jats:italic>Bartonella<\/jats:italic> bacteria were cultured from 37.2% (16\/43) of rodents examined, while <jats:italic>Bartonella<\/jats:italic> DNA was detected in 41.2% (28\/68) of rodents by polymerase chain reaction targeting citrate synthase (<jats:italic>gltA<\/jats:italic>) gene. Sequences of <jats:italic>gltA<\/jats:italic> showed that rodents in this region harbored multiple <jats:italic>Bartonella<\/jats:italic> strains, including <jats:italic>Bartonella elizabethae<\/jats:italic>, <jats:italic>Bartonella tribocorum<\/jats:italic>, <jats:italic>Bartonella grahamii<\/jats:italic>, and an unknown genogroup. The first three <jats:italic>Bartonella<\/jats:italic> species, known to be rat-associated and human cases linked, were commonly observed in wood mice (<jats:italic>Apodemus<\/jats:italic> [<jats:italic>Sylvaemus<\/jats:italic>] <jats:italic>uralensis<\/jats:italic>) (5\/8 positive with <jats:italic>B. elizabethae<\/jats:italic> and <jats:italic>B. tribocorum<\/jats:italic>) and social voles (<jats:italic>Microtus socialis<\/jats:italic>) (4\/6 positive with <jats:italic>B. grahamii<\/jats:italic> and <jats:italic>B. elizabethae<\/jats:italic>) in this study. The frequent distribution of these <jats:italic>Bartonella<\/jats:italic> species suggests that they may contribute to unidentified clinical infections. The unknown genogroup was observed in 24 <jats:italic>Bartonella<\/jats:italic> isolates and\/or DNA extracts from heart tissues, all of which were obtained from <jats:italic>Libyan jirds<\/jats:italic> (<jats:italic>Meriones libycus<\/jats:italic>). Further characterization of the bacterial cultures based on sequence analysis of four additional genes (<jats:italic>ftsZ<\/jats:italic>, <jats:italic>nuoG<\/jats:italic>, <jats:italic>rpoB<\/jats:italic>, and <jats:italic>ssrA<\/jats:italic>) supported that the jird-associated <jats:italic>Bartonella<\/jats:italic> strains comprise a distinct monophyletic clade. The impact of this bacterium on wildlife and human health needs to be determined.<\/jats:p>","DOI":"10.4269\/ajtmh.16-0041","type":"journal-article","created":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T03:05:26Z","timestamp":1462849526000},"page":"466-471","source":"Crossref","is-referenced-by-count":25,"title":["Prevalence and Diversity of Bartonella Species in Rodents from Georgia (Caucasus)"],"prefix":"10.4269","volume":"95","author":[{"given":"Lile","family":"Malania","sequence":"first","affiliation":[{"name":"1General Bacteriology Laboratory, National Center for Disease Control and Public Health, Tbilisi, Republic of Georgia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Bai","sequence":"additional","affiliation":[{"name":"2Bacterial Diseases Branch, Division of Vector-Borne Disease, Centers for Disease Control and Prevention, Fort Collins, Colorado."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn M.","family":"Osikowicz","sequence":"additional","affiliation":[{"name":"2Bacterial Diseases Branch, Division of Vector-Borne Disease, Centers for Disease Control and Prevention, Fort Collins, Colorado."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikoloz","family":"Tsertsvadze","sequence":"additional","affiliation":[{"name":"1General Bacteriology Laboratory, National Center for Disease Control and Public Health, Tbilisi, Republic of Georgia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guram","family":"Katsitadze","sequence":"additional","affiliation":[{"name":"1General Bacteriology Laboratory, National Center for Disease Control and Public Health, Tbilisi, Republic of Georgia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paata","family":"Imnadze","sequence":"additional","affiliation":[{"name":"1General Bacteriology Laboratory, National Center for Disease Control and Public Health, Tbilisi, Republic of Georgia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kosoy","sequence":"additional","affiliation":[{"name":"2Bacterial Diseases Branch, Division of Vector-Borne Disease, Centers for Disease Control and Prevention, Fort Collins, Colorado."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Trends Microbiol","first-page":"279","article-title":"Bartonella interactions with endothelial cells and erythrocytes","volume":"9","author":"Dehio","year":"2001"},{"key":"ref2","series-title":"Ann Trop Med Parasitol","first-page":"317","article-title":"Grahamella in small woodland mammals in the U.K.\u2013isolation, prevalence and host-specificity","volume":"88","author":"Birtles","year":"1994"},{"key":"ref3","series-title":"Am J Trop Med Hyg","first-page":"622","article-title":"Genetic and ecologic characteristics of Bartonella communities in rodents in southern 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