{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:22:42Z","timestamp":1783164162873,"version":"3.54.6"},"reference-count":20,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,8,3]]},"abstract":"<jats:p><jats:italic>Strongyloides<\/jats:italic> hyperinfection syndrome and disseminated strongyloidiasis frequently occur in immunocompromised persons and can lead to high complication and mortality rates. Thus, detection of <jats:italic>Strongyloides stercolaris<\/jats:italic> in those patients is crucial. The present study aimed to determine the prevalence of strongyloidiasis and compare the detection rates of different strongyloidiasis detection methods. We conducted a cross-sectional study of 135 adults with various immunocompromising conditions (corticosteroid usage, chemotherapy, hematologic malignancies, organ transplants, use of immunosuppressive agents, and symptomatic human immunodeficiency virus infection) in Phramongkutklao Hospital, Bangkok, Thailand. All patients were asked to undergo serology testing for <jats:italic>Strongyloides<\/jats:italic> IgG by indirect enzyme-linked immunosorbent assay (ELISA), and 3 days of stool collection for use in a simple smear along with formalin\u2013ether concentration and agar plate techniques. Prevalence rates of strongyloidiasis were 5% by stool concentration technique, 5.4% by IgG-ELISA, and 6.7% by agar plate culture. Three of the eight strongyloidiasis cases in this study had hyperinfection syndrome. The tested risk factors of age, sex, occupation, and immunocompromising condition were not associated with <jats:italic>Strongyloides<\/jats:italic> infestation. Serology was only 42.9% sensitive (positive predictive value), but it was 96.3% specific (negative predictive value). In conclusion, prevalence rates of strongyloidiasis in this study were 5\u20137%. Although agar plate culture was the most sensitive technique, the other diagnostic methods might be alternatively used.<\/jats:p>","DOI":"10.4269\/ajtmh.16-0068","type":"journal-article","created":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T03:05:34Z","timestamp":1465873534000},"page":"401-404","source":"Crossref","is-referenced-by-count":67,"title":["Comparative Diagnosis of Strongyloidiasis in Immunocompromised Patients"],"prefix":"10.4269","volume":"95","author":[{"given":"Viravarn","family":"Luvira","sequence":"first","affiliation":[{"name":"1Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand."},{"name":"2Division of Infectious Diseases, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kitti","family":"Trakulhun","sequence":"additional","affiliation":[{"name":"2Division of Infectious Diseases, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathirut","family":"Mungthin","sequence":"additional","affiliation":[{"name":"3Department of Parasitology, Phramongkutklao College of Medicine, Bangkok, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tawee","family":"Naaglor","sequence":"additional","affiliation":[{"name":"3Department of Parasitology, Phramongkutklao College of Medicine, Bangkok, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirattar","family":"Chantawat","sequence":"additional","affiliation":[{"name":"2Division of Infectious Diseases, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wallop","family":"Pakdee","sequence":"additional","affiliation":[{"name":"4Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danabhand","family":"Phiboonbanakit","sequence":"additional","affiliation":[{"name":"2Division of Infectious Diseases, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paron","family":"Dekumyoy","sequence":"additional","affiliation":[{"name":"4Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Clin Microbiol Rev","first-page":"208","article-title":"Strongyloides stercoralis in the immunocompromised population","volume":"17","author":"Keiser","year":"2004"},{"key":"ref2","series-title":"Clin Infect Dis","first-page":"1040","article-title":"Diagnosis of Strongyloides stercoralis infection","volume":"33","author":"Siddiqui","year":"2001"},{"key":"ref3","series-title":"PLoS 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immunodeficiency virus infection a risk factor for Strongyloides stercoralis hyperinfection and dissemination","volume":"6","author":"Siegel","year":"2012"},{"key":"ref20","series-title":"Southeast Asian J Trop Med Public Health","first-page":"841","article-title":"Detection of opportunistic and non-opportunistic intestinal parasites and liver flukes in HIV-positive and HIV-negative subjects","volume":"36","author":"Pinlaor","year":"2005"}],"container-title":["The American Society of Tropical Medicine and 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