{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:26:01Z","timestamp":1761017161810},"reference-count":23,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,7]]},"abstract":"<jats:p>Solitary cysticercus granuloma is a common neuroimaging abnormality in Indian patients with new-onset epilepsy. Calcific transformation of cysticercus granuloma is frequently associated with seizure recurrence. We evaluated predictors of lesion calcification in patients with solitary cysticercus granuloma and new-onset seizures. One hundred twenty-two patients, with new-onset seizures and a solitary cysticercus granuloma of the brain, were enrolled. All patients were clinically and radiologically evaluated and were treated with antiepileptic drug drugs. No patient received albendazole or corticosteroids. The follow-up period was of 1 year. Follow-up computed tomography was performed after 3 and 6 months. In 68 (54.8%) patients, solitary cysticercus granuloma had transformed into a calcified lesion. On logistic regression analysis, moderate-to-severe edema was a significant factor that predicted calcific transformation of the cysticercus granuloma (odds ratio: 3.325; 95% confidence interval: 1.502\u20137.362). During 1 year of follow-up, 19 (15.6%) patients experienced seizure recurrence. In 16 patients with seizure recurrence, cysticercus granuloma had transformed in to a calcified lesion. In conclusion, in solitary cysticercus granuloma, calcification of the lesion can be predicted if larger amount of perilesional edema is present. Calcification of the granuloma significantly predicts seizure recurrence.<\/jats:p>","DOI":"10.4269\/ajtmh.16-0070","type":"journal-article","created":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T02:38:47Z","timestamp":1468895927000},"page":"623-628","source":"Crossref","is-referenced-by-count":13,"title":["Predictors of Lesion Calcification in Patients with Solitary Cysticercus Granuloma and New-Onset Seizures"],"prefix":"10.4269","volume":"95","author":[{"given":"Lalit","family":"Mahajan","sequence":"first","affiliation":[{"name":"1Department of Neurology, King George Medical University, Uttar Pradesh, Lucknow, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hardeep Singh","family":"Malhotra","sequence":"additional","affiliation":[{"name":"1Department of Neurology, King George Medical University, Uttar Pradesh, Lucknow, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravindra Kumar","family":"Garg","sequence":"additional","affiliation":[{"name":"1Department of Neurology, King George Medical University, Uttar Pradesh, Lucknow, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neeraj","family":"Kumar","sequence":"additional","affiliation":[{"name":"1Department of Neurology, King George Medical University, Uttar Pradesh, Lucknow, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Praveen Kumar","family":"Sharma","sequence":"additional","affiliation":[{"name":"1Department of Neurology, King George Medical University, Uttar Pradesh, Lucknow, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Verma","sequence":"additional","affiliation":[{"name":"1Department of Neurology, King George Medical University, Uttar Pradesh, Lucknow, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imran","family":"Rizvi","sequence":"additional","affiliation":[{"name":"1Department of Neurology, King George Medical University, Uttar Pradesh, Lucknow, India."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Epilepsy Curr","first-page":"23","article-title":"Neurocysticercosis and epilepsy","volume":"14","author":"Burneo","year":"2014"},{"key":"ref2","series-title":"Lancet Neurol","first-page":"1202","article-title":"Clinical symptoms, diagnosis, and treatment of neurocysticercosis","volume":"13","author":"Garcia","year":"2014"},{"key":"ref3","series-title":"Expert Rev Anti Infect Ther","first-page":"597","article-title":"Solitary cysticercus granuloma","volume":"10","author":"Garg","year":"2012"},{"key":"ref4","series-title":"Neurosurg Focus","first-page":"e4","article-title":"Single enhancing computerized tomography-detected lesion in immunocompetent patients","volume":"12","author":"Garg","year":"2002"},{"key":"ref5","series-title":"Epilepsia","first-page":"48","article-title":"The syndromic classification of the International League Against Epilepsy: a hospital-based study from south India","volume":"39","author":"Murthy","year":"1998"},{"key":"ref6","series-title":"J Trop Pediatr","first-page":"266","article-title":"Single small enhancing computed tomographic lesions in Indian children\u2014II. 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