{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T07:45:36Z","timestamp":1783755936266,"version":"3.55.0"},"reference-count":24,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6,7]]},"abstract":"<jats:p><jats:italic>Burkholderia pseudomallei<\/jats:italic> is the causative agent of melioidosis, an emerging tropical disease of high mortality. Sub-Saharan Africa represents potential melioidosis \u201chotspots\u201d; however, to date, only a few cases have been reported. Here in, we compared the inflammatory patterns induced by a <jats:italic>B. pseudomallei<\/jats:italic> strain recently isolated from a fatal Gabonese case with the Thai reference strain <jats:italic>B. pseudomallei<\/jats:italic>-1026b and <jats:italic>Burkholderia thailandensis<\/jats:italic>-E264. Ex vivo, no differences were observed in terms of cellular responsiveness between strains. However, when compared with the <jats:italic>B. pseudomallei<\/jats:italic>-1026b strain, the Gabonese isolate was significantly less virulent in terms of bacterial dissemination, inflammatory response, and organ damage in mice. Genomic comparison between strains showed differences in regions containing a fimbriae\/adhesion virulence protein. In addition to a lack of microbiology facilities, differences in virulence of <jats:italic>Burkholderia<\/jats:italic> strains might contribute to the diverse global clinical occurrence of melioidosis.<\/jats:p>","DOI":"10.4269\/ajtmh.16-0121","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T17:24:20Z","timestamp":1489512260000},"page":"1365-1369","source":"Crossref","is-referenced-by-count":3,"title":["Differences in Inflammation Patterns Induced by African and Asian Burkholderia pseudomallei Isolates in Mice"],"prefix":"10.4269","volume":"96","author":[{"given":"Tassili A. F.","family":"Weehuizen","sequence":"first","affiliation":[{"name":"Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands."},{"name":"Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Birnie","sequence":"additional","affiliation":[{"name":"Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands."},{"name":"Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands."},{"name":"Centre de Recherches M\u00e9dicales en Lambar\u00e9n\u00e9 (CERMEL), Lambar\u00e9n\u00e9, Gabon."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Ferwerda","sequence":"additional","affiliation":[{"name":"Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands."},{"name":"Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands."},{"name":"Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joris J. T. H.","family":"Roelofs","sequence":"additional","affiliation":[{"name":"Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex F.","family":"de Vos","sequence":"additional","affiliation":[{"name":"Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands."},{"name":"Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin P.","family":"Grobusch","sequence":"additional","affiliation":[{"name":"Centre de Recherches M\u00e9dicales en Lambar\u00e9n\u00e9 (CERMEL), Lambar\u00e9n\u00e9, Gabon."},{"name":"Division of Infectious Diseases, Center for Tropical Medicine and Travel Medicine, Academic Medical Center, Amsterdam, The Netherlands."},{"name":"Institute of Tropical Medicine, University of T\u00fcbingen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Joost","family":"Wiersinga","sequence":"additional","affiliation":[{"name":"Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands."},{"name":"Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands."},{"name":"Division of Infectious Diseases, Center for Tropical Medicine and Travel Medicine, Academic Medical Center, Amsterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"N Engl J Med","first-page":"1035","article-title":"Melioidosis","volume":"367","author":"Wiersinga","year":"2012"},{"key":"ref2","series-title":"Clin Microbiol Rev","first-page":"383","article-title":"Melioidosis: epidemiology, pathophysiology, and management","volume":"18","author":"Cheng","year":"2005"},{"key":"ref3","series-title":"Fed Regist","first-page":"61083","article-title":"Possession, use, and transfer of select agents and toxins; biennial review. 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Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/96\/6\/article-p1365.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/96\/6\/article-p1365.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/96\/6\/article-p1365.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T22:27:57Z","timestamp":1723069677000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/96\/6\/article-p1365.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,7]]},"references-count":24,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.16-0121","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,7]]}}}