{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T11:27:10Z","timestamp":1780572430327,"version":"3.54.1"},"reference-count":25,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11,2]]},"abstract":"<jats:p>We conducted a prospective study to measure dengue virus (DENV) antibody seroconversion in travelers to dengue-endemic areas. Travelers seen in the Boston Area Travel Medicine Network planning to visit dengue-endemic countries for \u2265 2 weeks were enrolled from 2009 to 2010. Pre- and post-travel blood samples and questionnaires were collected. Post-travel sera were tested for anti-DENV IgG by indirect IgG enzyme-linked immunosorbent assay (ELISA) and anti-DENV IgM by capture IgM ELISA. Participants with positive post-travel anti-DENV IgG or IgM were tested for pre-travel anti-DENV IgG and IgM; they were excluded from the seroconversion calculation if either pre-travel anti-DENV IgG or IgM were positive. Paired sera and questionnaires were collected for 62% (589\/955) of enrolled travelers. Most participants were 19\u201364 years of age, female, and white. The most common purposes of travel were tourism and visiting friends and relatives; most trips were to Asia or Africa. Median length of travel was 21 days. DENV antibody seroconversion by either anti-DENV IgM or IgG ELISA was 2.9\u20136.8%; lower range percent excluded potential false-positive anti-DENV IgG due to receipt of yellow fever or Japanese encephalitis vaccines at enrollment; upper range percent excluded proven false-positive anti-DENV IgM. Eighteen percent of those with seroconversion reported dengue-like symptoms. Seroconversion was documented for travel to Africa as well as countries and regions known to be highly dengue endemic (India, Brazil, southeast Asia). Given widespread risk of dengue, travel medicine counseling should include information on risk of dengue in endemic areas and advice on preventing insect bites and seeking prompt medical attention for febrile illness.<\/jats:p>","DOI":"10.4269\/ajtmh.16-0159","type":"journal-article","created":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T02:43:08Z","timestamp":1472524988000},"page":"1130-1136","source":"Crossref","is-referenced-by-count":20,"title":["Dengue Virus Seroconversion in Travelers to Dengue-Endemic Areas"],"prefix":"10.4269","volume":"95","author":[{"given":"Rosemary M.","family":"Olivero","sequence":"first","affiliation":[{"name":"Section of Pediatric Infectious Diseases, Boston Medical Center, Boston, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davidson H.","family":"Hamer","sequence":"additional","affiliation":[{"name":"Center for Global Health and Development, Boston University School of Public Health (BUSPH), Boston, Massachusetts."},{"name":"Department of Global Health, Boston University School of Public Health (BUSPH), Boston, Massachusetts."},{"name":"Section of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"MacLeod","sequence":"additional","affiliation":[{"name":"Center for Global Health and Development, Boston University School of Public Health (BUSPH), Boston, Massachusetts."},{"name":"Department of Global Health, Boston University School of Public Health (BUSPH), Boston, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Benoit","sequence":"additional","affiliation":[{"name":"Section of Pediatric Infectious Diseases, Boston Medical Center, Boston, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Sanchez-Vegas","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Miami Children's Hospital, Miami, Florida."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily S.","family":"Jentes","sequence":"additional","affiliation":[{"name":"Division of Global Migration and Quarantine, Centers for Disease Control and Prevention, Atlanta, Georgia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin H.","family":"Chen","sequence":"additional","affiliation":[{"name":"Travel Medicine Center, Mount Auburn Hospital, Cambridge, Massachusetts."},{"name":"Harvard Medical School, Boston, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Global Health and Population, Harvard T. H. Chan School of Public Health, Boston, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Marano","sequence":"additional","affiliation":[{"name":"Division of Global Migration and Quarantine, Centers for Disease Control and Prevention, Atlanta, Georgia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad A.","family":"Yanni","sequence":"additional","affiliation":[{"name":"Division of Global Migration and Quarantine, Centers for Disease Control and Prevention, Atlanta, Georgia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winnie W.","family":"Ooi","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Lahey Clinic Medical Center, Burlington, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolf W.","family":"Karchmer","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, Massachusetts."},{"name":"Division of Infectious Disease, Beth Israel Deaconess Medical Center, Boston, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Kogelman","sequence":"additional","affiliation":[{"name":"Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth D.","family":"Barnett","sequence":"additional","affiliation":[{"name":"Section of Pediatric Infectious Diseases, Boston Medical Center, Boston, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control","author":"World Health Organization","year":"2009"},{"key":"ref2","series-title":"Nature","first-page":"504","article-title":"The global distribution and burden of dengue","volume":"120","author":"Bhatt","year":"2013"},{"key":"ref3","series-title":"Am J Epidemiol","first-page":"653","article-title":"Risk factors in dengue shock syndrome: a prospective epidemiologic study in Rayong, Thailand I. The 1980 outbreak","volume":"120","author":"Sangkawibha","year":"1984"},{"key":"ref4","series-title":"N Engl J Med","first-page":"924","article-title":"Dengue in travelers","volume":"353","author":"Wilder-Smith","year":"2005"},{"key":"ref5","series-title":"J Travel Med","first-page":"8","article-title":"Travel-associated dengue infections in the United States, 1996 to 2005","volume":"17","author":"Mohammed","year":"2010"},{"key":"ref6","series-title":"MMWR","first-page":"715","article-title":"Travel-associated dengue surveillance: United States, 2006\u20132008","volume":"59","author":"Centers for Disease Control and Prevention (CDC)","year":"2010"},{"key":"ref7","series-title":"Emerg Infect Dis","first-page":"824","article-title":"Dengue seroconversion among Israeli travelers to tropical countries","volume":"5","author":"Potasman","year":"1999"},{"key":"ref8","series-title":"Trop Med Int Health","first-page":"331","article-title":"Incidence and risk factors of probable dengue virus infection among Dutch travelers to Asia","volume":"7","author":"Cobelens","year":"2002"},{"key":"ref9","series-title":"Emerg Infect Dis","first-page":"821","article-title":"Travel-related dengue virus infection, the Netherlands, 2006\u20132007","volume":"17","author":"Baaten","year":"2011"},{"key":"ref10","series-title":"Travel Med Infect Dis","first-page":"210","article-title":"Seroepidemiology of dengue in travelers: a paired sera analysis","volume":"11","author":"Leder","year":"2013"},{"key":"ref11","series-title":"Eur J Clin Microbiol Infect Dis","first-page":"1203","article-title":"Incidence and seroprevalence of dengue virus infections in Australian travelers to Asia","volume":"31","author":"Ratnam","year":"2012"},{"key":"ref12","series-title":"J Clin Microbiol","first-page":"4217","article-title":"Immunoassay targeting nonstructural protein 5 to differentiate West Nile Virus infection from dengue and St. Louis encephalitis virus infections and from flavivirus infection","volume":"41","author":"Wong","year":"2003"},{"key":"ref13","series-title":"J Clin Microbiol","first-page":"1827","article-title":"Detection of anti-arboviral immunoglobuoin G by using a monoclonal antibody-based caputre enzyme-linnked immunsorbent assay","volume":"38","author":"Johnson","year":"2000"},{"key":"ref14","series-title":"Clin Vaccine Immunol","first-page":"358","article-title":"Optimization of the cut-off value for a commercial anti-dengue virus IgG immunoassay","volume":"20","author":"Marrero-Santos","year":"2013"},{"key":"ref15","series-title":"Med Microbiol Immunol (Berl)","first-page":"199","article-title":"Cross-reactivity in flavivirus serology: new implications of an old finding?","volume":"190","author":"Allwinn","year":"2002"},{"key":"ref16","series-title":"Am J Trop Med Hyg","first-page":"171","article-title":"Chikungunya and dengue fever among hospitalized febrile patients in northern Tanzania","volume":"86","author":"Hertz","year":"2012"},{"key":"ref17","series-title":"Emerg Infect Dis","first-page":"1349","article-title":"Dengue virus infections in Africa","volume":"17","author":"Amarasinghe","year":"2011"},{"key":"ref18","series-title":"Virol J","first-page":"371","article-title":"Seroprevalence and distribution of arboviral infections among rural Kenyan adults: a cross-sectional study","volume":"8","author":"Mease","year":"2011"},{"key":"ref19","series-title":"Nature","first-page":"504","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013"},{"key":"ref20","series-title":"Comprehensive Guidelines for Prevention and Control of Dengue and Dengue Haemorrhagic Fever","article-title":"Chapter 8: Dengue vectors","year":"2009"},{"key":"ref21","series-title":"Emerg Infect Dis","first-page":"86","article-title":"Texas lifestyle limits transmission of dengue virus","volume":"9","author":"Reiter","year":"2003"},{"key":"ref22","series-title":"J Vector Ecol","first-page":"158","article-title":"Landing periodicity of Aedes aegypti with implications for dengue transmission in Trinidad, West Indies","volume":"25","author":"Chadee","year":"2000"},{"key":"ref23","series-title":"J Travel Med","first-page":"346","article-title":"Acceptability of hypothetical dengue vaccines among travelers","volume":"20","author":"Benoit","year":"2013"},{"key":"ref24","series-title":"First Dengue Vaccine Approved by Mexico","author":"New York Times","year":"2015"},{"key":"ref25","series-title":"Viruses","first-page":"1800","article-title":"Next generation dengue vaccines: novel strategies currently under development","volume":"3","author":"Durbin","year":"2011"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/95\/5\/article-p1130.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/95\/5\/article-p1130.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/95\/5\/article-p1130.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T21:53:06Z","timestamp":1723067586000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/95\/5\/article-p1130.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,2]]},"references-count":25,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.16-0159","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,2]]}}}