{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:12:16Z","timestamp":1789881136161,"version":"4.0.1"},"reference-count":15,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,7]]},"abstract":"<jats:p>Santa Catarina State in southern Brazil is the state with the second highest number of laboratory-confirmed cases of spotted fever illness in Brazil. However, all these cases were confirmed solely by serological analysis (seroconversion to spotted fever group rickettsiae), which has not allowed identification of the rickettsial agent. Here, a clinical case of spotted fever illness from Santa Catarina is shown by seroconversion and molecular analysis to be caused by <jats:italic>Rickettsia<\/jats:italic> sp. strain Atlantic rainforest. This is the third confirmed clinical case due to this emerging rickettsial agent in Brazil. Like the previous two cases, the patient presented an inoculation eschar at the tick bite site. Our molecular diagnosis was performed on DNA extracted from the crust removed from the eschar. These results are supported by previous epidemiological studies in Santa Catarina, which showed that nearly 10% of the most common human-biting ticks were infected by <jats:italic>Rickettsia<\/jats:italic> sp. strain Atlantic rainforest.<\/jats:p>","DOI":"10.4269\/ajtmh.16-0192","type":"journal-article","created":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T03:28:40Z","timestamp":1466479720000},"page":"551-553","source":"Crossref","is-referenced-by-count":60,"title":["Rickettsia sp. Strain Atlantic Rainforest Infection in a Patient from a Spotted Fever-Endemic Area in Southern Brazil"],"prefix":"10.4269","volume":"95","author":[{"given":"Felipe S.","family":"Krawczak","sequence":"first","affiliation":[{"name":"1Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebasti\u00e1n","family":"Mu\u00f1oz-Leal","sequence":"additional","affiliation":[{"name":"1Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina","family":"Guztzazky","sequence":"additional","affiliation":[{"name":"2Funda\u00e7\u00e3o Universidade Regional de Blumenau, Blumenau, Santa Catarina, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan V.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"3Secretaria de Vigil\u00e2ncia em Sa\u00fade, Minist\u00e9rio da Sa\u00fade, Bras\u00edlia, Distrito Federal, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana C. P.","family":"Santos","sequence":"additional","affiliation":[{"name":"4Instituto Adolfo Lutz, Secretaria de Estado da Sa\u00fade, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo N.","family":"Angerami","sequence":"additional","affiliation":[{"name":"5Hospital das Cl\u00ednicas, Universidade Estadual de Campinas, Campinas, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Moraes-Filho","sequence":"additional","affiliation":[{"name":"1Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio C.","family":"de Souza","sequence":"additional","affiliation":[{"name":"2Funda\u00e7\u00e3o Universidade Regional de Blumenau, Blumenau, Santa Catarina, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo B.","family":"Labruna","sequence":"additional","affiliation":[{"name":"1Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Emerg Infect Dis","first-page":"521","article-title":"Novel spotted fever group rickettsioses, Brazil","volume":"16","author":"Spolidorio","year":"2010"},{"key":"ref2","series-title":"Emerg Infect Dis","first-page":"275","article-title":"Eschar-associated spotted fever rickettsiosis, Bahia, Brazil","volume":"17","author":"Silva","year":"2011"},{"key":"ref3","series-title":"Clin Microbiol Rev","first-page":"657","article-title":"Update on tick-borne rickettsioses around the world: a geographic approach","volume":"26","author":"Parola","year":"2013"},{"key":"ref4","series-title":"J Med Entomol","article-title":"Isolation of the pathogen Rickettsia sp. strain Atlantic rainforest from its presumed tick vector, Amblyomma ovale (Acari: Ixodidae), from two areas of Brazil","author":"Nieri-Bastos","year":"2016"},{"key":"ref5","series-title":"Clin Infect Dis","first-page":"1188","article-title":"Rickettsia parkeri rickettsiosis and its clinical distinction from Rocky Mountain spotted fever","volume":"47","author":"Paddock","year":"2008"},{"key":"ref6","series-title":"Rev Inst Med Trop Sao Paulo","first-page":"337","article-title":"Serological evidence of Rickettsia parkeri as the etiological agent of rickettsiosis in Uruguay","volume":"51","author":"Conti-D\u00edaz","year":"2009"},{"key":"ref7","series-title":"Am J Trop Med Hyg","first-page":"1156","article-title":"Rickettsia parkeri rickettsiosis in different ecological regions of Argentina and its association with Amblyomma tigrinum as a potential vector","volume":"91","author":"Romer","year":"2014"},{"issue":"(Suppl)","key":"ref8","series-title":"Clin Microbiol Infect","first-page":"207","article-title":"Brazilian spotted fever: two faces of a same disease? A comparative study of clinical aspects between an old and a new endemic area in Brazil","volume":"2","author":"Angerami","year":"2009"},{"key":"ref9","series-title":"Scientia Plena","first-page":"1","article-title":"Febre maculosa: uma an\u00e1lise epidemiol\u00f3gica dos registros dosistema de vigil\u00e2ncia do Brasil","volume":"10","author":"Barros e Silva","year":"2014"},{"key":"ref10","series-title":"Ticks Tick Borne Dis","first-page":"848","article-title":"Epidemiology of Rickettsia sp. strain Atlantic rainforest in a spotted fever-endemic area of southern Brazil","volume":"5","author":"Barbieri","year":"2014"},{"key":"ref11","series-title":"Vector Borne Zoonotic Dis","first-page":"249","article-title":"Prevalence of Rickettsia infection in dogs from the urban and rural areas of Monte Negro Municipality, western Amazon, Brazil","volume":"7","author":"Labruna","year":"2007"},{"key":"ref12","series-title":"Appl Environ Microbiol","first-page":"5569","article-title":"Isolation and identification of Rickettsia massiliae from Rhipicephalus sanguineus ticks collected in Arizona","volume":"72","author":"Eremeeva","year":"2006"},{"key":"ref13","series-title":"Int J Syst Evol Microbiol","first-page":"1449","article-title":"Phylogenetic analysis of members of the genus Rickettsia using the gene encoding the outer membrane protein rOmpB (ompB)","volume":"50","author":"Roux","year":"2000"},{"key":"ref14","series-title":"Mem Inst Oswaldo Cruz","first-page":"926","article-title":"Spotted fever group Rickettsia infecting ticks (Acari: Ixodidae) in the state of Santa Catarina, Brazil","volume":"106","author":"Medeiros","year":"2011"},{"key":"ref15","series-title":"Ticks Tick Borne Dis","first-page":"502","article-title":"Comparative evaluation of Amblyomma ovale ticks infected and noninfected by Rickettsia sp. strain Atlantic rainforest, the agent of an emerging rickettsiosis in Brazil","volume":"7","author":"Krawczak","year":"2016"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/95\/3\/article-p551.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/95\/3\/article-p551.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/95\/3\/article-p551.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T21:58:22Z","timestamp":1723067902000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/95\/3\/article-p551.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,7]]},"references-count":15,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.16-0192","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,7]]}}}