{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:28:20Z","timestamp":1761766100568},"reference-count":34,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,10,5]]},"abstract":"<jats:p>Chloroquine (CQ) remains the first-line treatment of malaria in Haiti. Given the challenges of conducting in vivo drug efficacy trials in low-endemic settings like Haiti, molecular surveillance for drug resistance markers is a reasonable approach for detecting resistant parasites. In this study, 349 blood spots were collected from suspected malaria cases in areas in and around Port-au-Prince from March to July 2010. Among them, 121 samples that were <jats:italic>Plasmodium falciparum<\/jats:italic> positive by polymerase chain reaction were genotyped for drug-resistant <jats:italic>pfcrt<\/jats:italic>, <jats:italic>pfdhfr<\/jats:italic>, <jats:italic>pfdhps<\/jats:italic>, and <jats:italic>pfmdr1<\/jats:italic> alleles. Among the 108 samples that were successfully sequenced for CQ resistant markers in <jats:italic>pfcrt<\/jats:italic>, 107 were wild type (CVMNK), whereas one sample carried a CQ-resistant allele (CVIET). Neutral microsatellite genotyping revealed that the CQ-resistant isolate was distinct from all other samples in this study. Furthermore, the remaining parasite specimens appeared to be genetically distinct from other reported Central and South American populations.<\/jats:p>","DOI":"10.4269\/ajtmh.16-0214","type":"journal-article","created":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T02:38:47Z","timestamp":1468895927000},"page":"811-816","source":"Crossref","is-referenced-by-count":14,"title":["Plasmodium falciparum Drug-Resistant Haplotypes and Population Structure in Postearthquake Haiti, 2010"],"prefix":"10.4269","volume":"95","author":[{"given":"Lindsay Carol","family":"Morton","sequence":"first","affiliation":[{"name":"1Centers for Disease Control and Prevention, Atlanta, Georgia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curtis","family":"Huber","sequence":"additional","affiliation":[{"name":"1Centers for Disease Control and Prevention, Atlanta, Georgia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila Akinyi","family":"Okoth","sequence":"additional","affiliation":[{"name":"1Centers for Disease Control and Prevention, Atlanta, Georgia."},{"name":"2Atlanta Research and Education Foundation, Decatur, Georgia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Griffing","sequence":"additional","affiliation":[{"name":"1Centers for Disease Control and Prevention, Atlanta, Georgia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Lucchi","sequence":"additional","affiliation":[{"name":"1Centers for Disease Control and Prevention, Atlanta, Georgia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragan","family":"Ljolje","sequence":"additional","affiliation":[{"name":"1Centers for Disease Control and Prevention, Atlanta, Georgia."},{"name":"2Atlanta Research and Education Foundation, Decatur, Georgia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Boncy","sequence":"additional","affiliation":[{"name":"3National Public Health Laboratory, Port-au-Prince, Haiti."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Oscar","sequence":"additional","affiliation":[{"name":"4Ministry of Health, Port-au-Prince, Haiti."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Townes","sequence":"additional","affiliation":[{"name":"1Centers for Disease Control and Prevention, Atlanta, Georgia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredith","family":"McMorrow","sequence":"additional","affiliation":[{"name":"1Centers for Disease Control and Prevention, Atlanta, Georgia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle A.","family":"Chang","sequence":"additional","affiliation":[{"name":"1Centers for Disease Control and Prevention, Atlanta, Georgia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkatachalam","family":"Udhayakumar","sequence":"additional","affiliation":[{"name":"1Centers for Disease Control and Prevention, Atlanta, Georgia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W.","family":"Barnwell","sequence":"additional","affiliation":[{"name":"1Centers for Disease Control and Prevention, Atlanta, Georgia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Emerg Infect Dis","first-page":"931","article-title":"Plasmodium malariae in Haitian refugees, Jamaica","volume":"13","author":"Lindo","year":"2007"},{"year":"2013","series-title":"Situation of Malaria in the Region of the Americas, 2000\u20132012","author":"Pan American Health Organization (PAHO)","key":"ref2"},{"key":"ref3","series-title":"Am J Trop Med Hyg","first-page":"840","article-title":"Molecular analysis of chloroquine and 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