{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:43:07Z","timestamp":1791902587875,"version":"4.3.4"},"reference-count":55,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,7]]},"abstract":"<jats:p>Scabies is a common contagious cutaneous disease and usually affects the young, characterized by polymorphous lesions that may present as burrows, pruritic papules, and inflammatory nodules. Bullous scabies (BS) is its rather rare subtype, mimicking bullous pemphigoid. We report a 15-year-old Chinese boy presenting with 1-month history of pruritic bullae on his penile skin, showing poor response to both topical steroids and systemic antihistamines, but cured by sulfur ointment alone. No recurrence occurred in the 5 years of follow-up. We also reviewed the published cases. Up to date, 44 cases, including the present, have been reported. Of them, 30 were male and 14 were female. The age range was from 1 to 89 years old, with a median age of 70.6 years. The bullous lesions may involve the arms, legs, trunk, genitals, feet, buttocks, thighs, neck, inguinal folds, and may even be generalized. Trunk and extremities are the most common involved locations. Facial or mucosa involvement had never been reported. The histological findings present as a subepidermal split with variable inflammatory infiltrate predominantly neutrophils, and eosinophilic spongiosis, or both. Eighteen of 32 patients showed positive deposition of linear-granular IgG or complement 3 alone or in various combinations, and five of 24 patients revealed circulating IgG. All the 40 cases with therapeutic details were cured by antiscabietic remedy. BS always involves the trunk and extremities. It has a predilection for elderlies and males. The treatments for BS are similar to those of classical scabies.<\/jats:p>","DOI":"10.4269\/ajtmh.16-0273","type":"journal-article","created":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T06:25:38Z","timestamp":1468304738000},"page":"689-693","source":"Crossref","is-referenced-by-count":27,"title":["Bullous Scabies"],"prefix":"10.4269","volume":"95","author":[{"given":"Di-Qing","family":"Luo","sequence":"first","affiliation":[{"name":"1Department of Dermatology, The Eastern Hospital of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Xing","family":"Huang","sequence":"additional","affiliation":[{"name":"2Department of Dermatology, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Hua","family":"Liu","sequence":"additional","affiliation":[{"name":"1Department of Dermatology, The Eastern Hospital of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Tang","sequence":"additional","affiliation":[{"name":"3Department of Paediatrics, The Eastern Hospital of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Kun","family":"Zhao","sequence":"additional","affiliation":[{"name":"1Department of Dermatology, The Eastern Hospital of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Sarkar","sequence":"additional","affiliation":[{"name":"4Department of Dermatology, Maulana Azad Medical College\u2013Lok Nayak Jai Prakash Narayan (LNJP) Hospital, New Delhi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Curr Probl Dermatol","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1159\/000424240","article-title":"Scabies: what is new?","volume":"22","author":"Orkin","year":"1995"},{"key":"ref2","series-title":"Arch Dis Child Educ Pract Ed","first-page":"e65","article-title":"Scabies in children","volume":"92","author":"Karthikeyan","year":"2007"},{"key":"ref3","series-title":"Lancet Infect Dis","first-page":"769","article-title":"Scabies: a ubiquitous neglected skin disease","volume":"6","author":"Hengge","year":"2006"},{"key":"ref4","series-title":"Dermatol Ther (Heidelb)","first-page":"279","article-title":"Scabies","volume":"22","author":"Hicks","year":"2009"},{"key":"ref5","series-title":"Lancet","first-page":"1767","article-title":"Scabies","volume":"367","author":"Heukelbach","year":"2006"},{"key":"ref6","series-title":"J Dtsch Dermatol Ges","first-page":"424","article-title":"Scabies","volume":"5","author":"Sunderk\u00f6tter","year":"2007"},{"key":"ref7","series-title":"Lancet","first-page":"819","article-title":"Scabies and pediculosis","volume":"355","author":"Chosidow","year":"2000"},{"key":"ref8","series-title":"Clin Infect Dis","first-page":"S146","article-title":"Scabies and pediculosis pubis: an update of treatment regimens and general review","volume":"35","author":"Wendel","year":"2002"},{"key":"ref9","series-title":"Med Clin North Am","first-page":"955","article-title":"The diagnosis and management of scabies","volume":"66","author":"Estes","year":"1982"},{"key":"ref10","series-title":"Cutis","first-page":"277","article-title":"Scabies: a cause of generalized urticaria","volume":"33","author":"Witkowski","year":"1984"},{"key":"ref11","series-title":"JAMA","first-page":"1937","article-title":"Scabies resembling Darier's disease","volume":"247","author":"Rudolph","year":"1982"},{"key":"ref12","series-title":"JAMA","first-page":"53","article-title":"Scabies masquerading as dermatitis herpetiformis","volume":"233","author":"Ackerman","year":"1975"},{"key":"ref13","series-title":"JAMA","first-page":"878","article-title":"Bullous scabies","volume":"230","author":"Bean","year":"1974"},{"key":"ref14","series-title":"Indian Dermatol Online J","first-page":"311","article-title":"Bullous scabies in an adult: a case report with review of literature","volume":"4","author":"Gutte","year":"2013"},{"key":"ref15","series-title":"J Am Acad Dermatol","first-page":"179","article-title":"Scabies presenting as bullous pemphigoid-like eruption","volume":"24","author":"Bhawan","year":"1991"},{"key":"ref16","series-title":"Actas Dermosifiliogr","first-page":"81","article-title":"Bullous scabies responding to ivermectin therapy","volume":"101","author":"Rossell","year":"2010"},{"key":"ref17","series-title":"J Am Acad Dermatol","first-page":"346","article-title":"Bullous scabies","volume":"49","author":"Shahab","year":"2003"},{"key":"ref18","series-title":"Dermatol Online J","first-page":"19","article-title":"Scabies presenting with bullous pemphigoid-like lesions","volume":"12","author":"Ansarin","year":"2006"},{"key":"ref19","series-title":"Clin Exp Dermatol","first-page":"93","article-title":"Bullous scabies in an adult","volume":"28","author":"Kaur","year":"2003"},{"key":"ref20","series-title":"Acta Derm Venereol","first-page":"167","article-title":"Bullous scabies","volume":"76","author":"Veraldi","year":"1996"},{"key":"ref21","series-title":"J Dermatol","first-page":"196","article-title":"A case of crusted scabies with a bullous pemphigoid-like eruption and nail involvement","volume":"33","author":"Nakamura","year":"2006"},{"key":"ref22","series-title":"Indian J Dermatol Venereol Leprol","first-page":"53","article-title":"Bullous scabies in a patient on anticancer therapy","volume":"71","author":"Jena","year":"2005"},{"key":"ref23","series-title":"J Am Acad Dermatol","first-page":"134","article-title":"Scabies mimicking bullous pemphigoid","volume":"20","author":"Viraben","year":"1989"},{"key":"ref24","series-title":"Br J Dermatol","first-page":"217","article-title":"Scabies associated with a bullous pemphigoid-like eruption","volume":"128","author":"Ostlere","year":"1993"},{"key":"ref25","series-title":"Clin Exp Dermatol","first-page":"293","article-title":"Bullous pemphigoid-like scabies","volume":"18","author":"Parodi","year":"1993"},{"key":"ref26","series-title":"Am J Dermatopathol","first-page":"590","article-title":"Localized bullous scabies: uncommon presentation of scabies","volume":"15","author":"Said","year":"1993"},{"key":"ref27","series-title":"Dermatology","first-page":"83","article-title":"Bullous scabies","volume":"190","author":"Haustein","year":"1995"},{"key":"ref28","series-title":"J Am Acad Dermatol","first-page":"878","article-title":"Association of scabies with a bullous pemphigoid-like eruption","volume":"34","author":"Slawsky","year":"1996"},{"key":"ref29","series-title":"Actas Dermosifiliogr","first-page":"219","article-title":"Sarna ampollosa: a prop\u00f3sito de dos casos","volume":"91","author":"Bosch-Garc\u00eda","year":"2000"},{"key":"ref30","series-title":"Hautarzt","first-page":"56","article-title":"Bullous scabies and scabies-triggered bullous pemphigoid","volume":"52","author":"Bornhovd","year":"2001"},{"key":"ref31","series-title":"J Cutan Med Surg","first-page":"175","article-title":"Recurrent bullous scabies","volume":"14","author":"Serra","year":"2010"},{"key":"ref32","series-title":"Cutis","first-page":"350","article-title":"Bullous scabies: a diagnostic challenge","volume":"82","author":"Wozniacka","year":"2008"},{"key":"ref33","series-title":"Postepy Dermatol Alergol","first-page":"161","article-title":"Bullous scabies: a case report","volume":"26","author":"Marciniak","year":"2009"},{"key":"ref34","series-title":"J Cutan Med Surg","first-page":"55","article-title":"Bullous scabies simulating pemphigoid","volume":"15","author":"Roxana Stan","year":"2011"},{"key":"ref35","series-title":"Int J Dermatol","first-page":"e265","article-title":"Bullous scabies failing to respond to glucocorticoids, immunoglobulin, and cyclophosphamide","volume":"53","author":"Chen","year":"2014"},{"key":"ref36","series-title":"Dermatol Online J","first-page":"13","article-title":"A dilemma: bullous pemphigoid-like eruption in scabies or scabies-induced bullous pemphigoid","volume":"12","author":"Balighi","year":"2006"},{"key":"ref37","series-title":"J Clin Dermatol","first-page":"484","article-title":"A case of bullous scabies [in Chinese]","volume":"43","author":"Zhang","year":"2014"},{"key":"ref38","series-title":"G Ital Dermatol Venereol","first-page":"337","article-title":"Bullous pemphigoid-like eruption subsequent to scabies: bullous scabies or bullous pemphigoid?","volume":"150","author":"Huang","year":"2015"},{"key":"ref39","series-title":"BMC Res Notes","first-page":"254","article-title":"Bullous scabies: a case report and review of the literature","volume":"8","author":"Maan","year":"2015"},{"key":"ref40","series-title":"Int J Dermatol","first-page":"e499","article-title":"A case of bullous scabies misdiagnosed as acquired epidermolysis bullosa","volume":"54","author":"Akin Belli","year":"2015"},{"key":"ref41","series-title":"Exp Ther Med","first-page":"1533","article-title":"A case of crusted scabies combined with bullous scabies","volume":"10","author":"Su","year":"2015"},{"key":"ref42","series-title":"Am J Dermatol","first-page":"590","article-title":"Localized bullous scabies","volume":"15","author":"Shirlene-Jay","year":"1993"},{"key":"ref43","series-title":"Hifu","first-page":"209","article-title":"A case of crusted scabies associated with bullous pemphigoid","volume":"41","author":"Kambara","year":"1999"},{"key":"ref44","series-title":"Hifu Rinsho","first-page":"1165","article-title":"A case of Norwegian scabies associated with bullous pemphigoid","volume":"42","author":"Inoue","year":"2000"},{"key":"ref45","series-title":"J Dermatol","first-page":"694","article-title":"Bullous scabies mimicking bullous pemphigoid","volume":"30","author":"Brar","year":"2003"},{"key":"ref46","series-title":"Nouv Dermatol","first-page":"218","article-title":"Bullous scabies: a sometimes difficult diagnosis","volume":"16","author":"Clyti","year":"1997"},{"key":"ref47","series-title":"Actas Dermosifiliogr","first-page":"81","article-title":"Bullous scabies responding to ivermectin therapy","volume":"101","author":"Galvany Rossell","year":"2010"},{"key":"ref48","series-title":"Rinsho Hifuka","first-page":"779","article-title":"Crusted scabies with bullous pemphigoid","volume":"48","author":"Ezaki","year":"1994"},{"key":"ref49","series-title":"Hifu Rinsho","first-page":"1883","article-title":"Crusted scabies with bullous eruption (in Japanese)","volume":"34","author":"Kurosawa","year":"1992"},{"key":"ref50","series-title":"Hautarzt","first-page":"96","article-title":"Bullous scabies in hereditary dystrophic epidermolysis bullosa","volume":"32","author":"Ponce-Navarez","year":"1981"},{"key":"ref51","series-title":"Acta Derm Venereol","first-page":"281","article-title":"Bullous eruption associated with scabies: evidence for scabetic induction of true bullous pemphigoid","volume":"80","author":"Konishi","year":"2000"},{"key":"ref52","series-title":"J Eur Acad Dermatol Venereol","first-page":"558","article-title":"Increased risk of pemphigoid following scabies: a population-based matched-cohort study","volume":"28","author":"Chung","year":"2014"},{"key":"ref53","series-title":"J Microbiol Immunol Infect","first-page":"276","article-title":"Risk factors for scabies in Taiwan","volume":"45","author":"Wang","year":"2012"},{"key":"ref54","series-title":"Am J Dermatopathol","first-page":"587","article-title":"Bullous tinea pedis with direct immunofluorescence positivity: when is a positive result not autoimmune bullous disease?","volume":"35","author":"Miller","year":"2013"},{"key":"ref55","series-title":"J Am Geriatr Soc","first-page":"1201","article-title":"Scabies manifesting as bullous pemphigus in a nursing home resident","volume":"62","author":"Mir","year":"2014"}],"container-title":["The American Society of Tropical Medicine and 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