{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:19:08Z","timestamp":1778656748307,"version":"3.51.4"},"reference-count":18,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2,8]]},"abstract":"<jats:p>Visceral leishmaniasis (VL) is associated with interstitial pneumonitis according to histology and radiology reports. However, studies to address the functional impact on respiratory function in patients are lacking. We assessed pulmonary function using noninvasive spirometry in a cross-sectional study of hospitalized adult VL patients from Minas Gerais, Brazil, without unrelated lung conditions or acute infections. Lung conditions were graded as normal, restrictive, obstructive, or mixed patterns, according to Brazilian consensus standards for spirometry. To control for regional patterns of lung function, we compared spirometry of patients with regional paired controls. Spirometry detected abnormal lung function in most VL patients (70%, 14\/20), usually showing a restrictive pattern, in contrast to regional controls and the standards for normal tests. Alterations in spirometry measurements correlated with hypoalbuminemia, the only laboratory value indicative of severity of parasitic disease. Abnormalities did not correlate with unrelated factors such as smoking or occupation. Clinical data including pulmonary symptoms and duration of therapy were also unrelated to abnormal spirometry findings. We conclude that the severity of VL is correlated with a restrictive pattern of lung function according to spirometry, suggesting that there may be interstitial lung involvement in VL. Further studies should address whether spirometry could serve as an index of disease severity in the management of VL.<\/jats:p>","DOI":"10.4269\/ajtmh.16-0275","type":"journal-article","created":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T03:00:40Z","timestamp":1480388440000},"page":"280-284","source":"Crossref","is-referenced-by-count":2,"title":["Disease Severity Prediction by Spirometry in Adults with Visceral Leishmaniasis from Minas Gerais, Brazil"],"prefix":"10.4269","volume":"96","author":[{"given":"Isabel A.","family":"Maia","sequence":"first","affiliation":[{"name":"Department of Infectious and Parasitic Diseases, Faculty of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank S.","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pathophysiology (LAFEx), Department of Biological Sciences (DECBI), Center of Research in Biological Sciences (NUPEB), Federal University of Ouro Preto (UFOP), Ouro Preto, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 Luis Pereira de","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Pneumology Division, Heart Institute, Hospital das Cl\u00ednicas da Universidade de S\u00e3o Paulo (HCFMUSP), S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heitor F.","family":"Andrade","sequence":"additional","affiliation":[{"name":"Laboratory of Protozoology, Instituto de Medicina Tropical de Sao Paulo (IMTSP), Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil."},{"name":"Department of Pathology, Faculty of Medicine, University of S\u00e3o Paulo (FMUSP), S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio C.","family":"Nicodemo","sequence":"additional","affiliation":[{"name":"Department of Infectious and Parasitic Diseases, Faculty of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valdir S.","family":"Amato","sequence":"additional","affiliation":[{"name":"Department of Infectious and Parasitic Diseases, Faculty of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Comp Immunol Microbiol Infect Dis","first-page":"305","article-title":"Leishmaniasis: current situation and new perspectives","volume":"27","author":"Dejeux","year":"2004"},{"key":"ref2","series-title":"BMC Infect Dis","first-page":"96","article-title":"Epidemiologic, clinical, diagnostic and therapeutic aspects of visceral leishmaniasis in renal transplant recipients: experience from thirty cases","volume":"15","author":"de Silva","year":"2015"},{"key":"ref3","series-title":"Lancet","first-page":"1716","article-title":"India makes good progress in combating 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Espirometria","volume":"28","author":"Pereira","year":"2002"},{"key":"ref14","series-title":"Int J Infect Dis","first-page":"46","article-title":"Current clinical, laboratory and treatment outcome characteristics of visceral leishmaniasis: results from a seven-year retrospective study in Greece","volume":"34","author":"Georgiadou","year":"2015"},{"key":"ref15","series-title":"Thorax","first-page":"822","article-title":"Characteristics of COPD in never-smokers and ever-smokers in the general population: results from the CanCOLD study","volume":"70","author":"Tan","year":"2015"},{"key":"ref16","series-title":"Thorax","first-page":"574","article-title":"Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis","volume":"59","author":"Gan","year":"2004"},{"key":"ref17","series-title":"Respir Physiol Neurobiol","first-page":"6","article-title":"Lung function, transfusion, pulmonary capillary blood volume and sickle cell disease","volume":"222","author":"Lunt","year":"2016"},{"key":"ref18","series-title":"Am J Trop Med Hyg","first-page":"787","article-title":"Treatment of visceral leishmaniasis in 2004","volume":"71","author":"Murray","year":"2004"}],"container-title":["The American Society of Tropical Medicine and 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